国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (2): 218-222.doi: 10.7518/gjkq.2019026

• 综述 • 上一篇    下一篇

浓缩生长因子在种植软硬组织增量方面的研究及应用

王瑜,王伟,顾新华()   

  1. 浙江大学医学院附属第一医院口腔科 杭州 310003
  • 收稿日期:2018-07-07 修回日期:2018-11-29 出版日期:2019-03-01 发布日期:2019-03-15
  • 通讯作者: 顾新华
  • 作者简介:王瑜,学士,Email: wyisoohyun@163.com
  • 基金资助:
    浙江省医药卫生科技计划(2018KY059)

Research and application of concentrated growth factor in soft and hard tissue increment of implants

Yu Wang,Wei Wang,Xinhua Gu()   

  1. Dept. of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
  • Received:2018-07-07 Revised:2018-11-29 Online:2019-03-01 Published:2019-03-15
  • Contact: Xinhua Gu
  • Supported by:
    This study was supported by Medical and Health Science and Technology Program of Zhejiang Province(2018KY059)

摘要:

浓缩生长因子作为新一代血小板浓缩制品,内含纤维蛋白及多种生长因子,对组织的修复再生具有重要意义。本文就浓缩生长因子的发展过程、制备、主要成分以及与口腔种植软组织和硬组织增量相关的研究、应用进行综述。

关键词: 浓缩生长因子, 生长因子, 种植, 组织增量

Abstract:

As a new generation of platelet concentrates, concentrated growth factor contains fibrin and many kinds of growth factors, which are of great importance to tissue regeneration. This article reviews the development, preparation, main components, related research and application of concentrated growth factor in soft and hard tissue increment of implants.

Key words: concentrated growth factor, growth factor, implant, tissue increment

中图分类号: 

  • R782.2 +4
[1] Assoian RK, Grotendorst GR, Miller DM , et al. Cellular transformation by coordinated action of three peptide growth factors from human platelets[J]. Nature, 1984,309(5971):804-806.
doi: 10.1038/309804a0 pmid: 6330562
[2] Whitman DH, Berry RL, Green DM . Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery[J]. J Oral Maxillofac Surg, 1997,55(11):1294-1299.
doi: 10.1016/S0278-2391(97)90187-7 pmid: 9371122
[3] Carano RA, Filvaroff EH . Angiogenesis and bone repair[J]. Drug Discov Today, 2003,8(21):980-989.
doi: 10.1016/S1359-6446(03)02866-6
[4] Choukroun J, Adda F, Schoeffler C , et al. An oppor-tunity in perio-implantology: the PRF[J]. Implanto-dontie, 2001,42:55-62.
[5] Dohan DM, Choukroun J, Diss A , et al. Platelet-rich fibrin (PRF): a second-generation platelet concen-trate. Part Ⅰ: technological concepts and evolution[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2006,101(3):e37-e44.
doi: 10.1016/j.tripleo.2005.07.008 pmid: 16504849
[6] Dohan DM, Choukroun J, Diss A , et al. Platelet-rich fibrin (PRF): a second-generation platelet concen-trate. PartⅡ: platelet-related biologic features[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2006,101(3):e45-e50.
doi: 10.1016/j.tripleo.2005.07.009 pmid: 16504850
[7] Dohan DM, Choukroun J, Diss A , et al. Platelet-rich fibrin (PRF): a second-generation platelet concen-trate. PartⅢ: leucocyte activation: a new feature for platelet concentrates[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2006,101(3):e51-e55.
doi: 10.1016/j.tripleo.2005.07.010 pmid: 16504851
[8] Park HC, Kim SG, Oh JS , et al. Early bone formation at a femur defect using CGF and PRF grafts in adult dogs: a comparative study[J]. Implant Dent, 2016,25(3):387-393.
doi: 10.1097/ID.0000000000000423
[9] Rodella LF, Favero G, Boninsegna R , et al. Growth factors, CD34 positive cells, and fibrin network an-alysis in concentrated growth factors fraction[J]. Microsc Res Tech, 2011,74(8):772-777.
doi: 10.1002/jemt.20968 pmid: 21780251
[10] Chen YH, Cai ZY, Zheng DG , et al. Inlay osteotome sinus floor elevation with concentrated growth factor application and simultaneous short implant placement in severely atrophic maxilla[J]. Sci Rep, 2016,6:27348.
doi: 10.1038/srep27348 pmid: 27250556
[11] Bozkurt Doğan Ş, öngöz Dede F, Ballı U , et al. Con-centrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth rando-mized clinical trial[J]. J Clin Periodontol, 2015,42(9):868-875.
doi: 10.1111/jcpe.12444 pmid: 26269089
[12] Isobe K, Watanebe T, Kawabata H , et al. Mechanical and degradation properties of advanced platelet-rich fibrin (A-PRF), concentrated growth factors (CGF), and platelet-poor plasma-derived fibrin (PPTF)[J]. Int J Implant Dent, 2017,3(1):17.
doi: 10.1186/s40729-017-0081-7 pmid: 28466249
[13] 刘琳, 董凯, 柳忠豪 . 浓缩生长因子提取液对MC3T3-E1细胞影响的实验研究[J]. 实用口腔医学杂志, 2015,31(3):309-312.
doi: 10.3969/j.issn.1001-3733.2015.03.02
Liu L, Dong K, Liu ZH . The effect of concentrate growth factor extract on MC3T3-E1 cells[J]. J Pract Stomatol, 2015,31(3):309-312.
doi: 10.3969/j.issn.1001-3733.2015.03.02
[14] 柳宏志, 李超, 王天祥 , 等. CGF联合骨代用品在即刻种植中修复种植体周围骨缺损的实验研究[J]. 口腔颌面外科杂志, 2012,22(4):277-282.
doi: 10.3969/j.issn.1005-4979.2012.04.012
Liu HZ, Li C, Wang TX , et al. In vivo bone response to CGF complex with bone substitute material at the bone/dental implant interface[J]. J Oral Maxillofac Surg, 2012,22(4):277-282.
doi: 10.3969/j.issn.1005-4979.2012.04.012
[15] 孟海锋 . 前牙即刻种植同期CGF辅助的引导骨再生解决骨缺损临床效果分析[J]. 浙江创伤外科, 2015,20(4):724-726.
doi: 10.3969/j.issn.1009-7147.2015.04.047
Meng HF . Clinical analysis of immediate implant assisted simultaneous CGF guided bone regeneration in the treatment of bone defects[J]. Zhejiang J Traumat Surg, 2015,20(4):724-726.
doi: 10.3969/j.issn.1009-7147.2015.04.047
[16] 杨立明, 陈淑萍, 李恩洪 . 浓缩生长因子(CGF)在即刻种植修复应用中的牙龈美学研究[J]. 中国美容医学, 2015,24(1):63-65.
Yang LM, Chen SP, Li EH . The clinical research on the gingival aesthetics of concentrate growth factors on immediate implant and immediate prosjournal[J]. Chin J Aesthet Med, 2015,24(1):63-65.
[17] Durmuşlar MC, Balli U, Dede Fö , et al. Histological evaluation of the effect of concentrated growth factor on bone healing[J]. J Craniofac Surg, 2016,27(6):1494-1497.
doi: 10.1097/SCS.0000000000002873 pmid: 27428921
[18] Yang LM, Liu ZZ, Chen SP , et al. The study of the effect of concentrated growth factors (CGF) on the new bone regeneration of immediate implant[J]. Adv Mat Res, 2015,1088:500-502.
doi: 10.4028/www.scientific.net/AMR.1088.500
[19] 李娜, 刘敏 . 不同口腔修复膜材料在牙种植中引导骨再生的临床效果观察[J]. 中外医学研究, 2016,14(21):15-17.
doi: 10.14033/j.cnki.cfmr.2016.21.007
Li N, Liu M . Clinical efficacy observation of diffe-rent dental membrane materials in dental implant guided bone regeneration[J]. Chin Foreign Med Res, 2016,14(21):15-17.
doi: 10.14033/j.cnki.cfmr.2016.21.007
[20] Wang F, Li Q, Wang ZL . A comparative study of the effect of Bio-Oss ® in combination with concentrated growth factors or bone marrow-derived mesenchymal stem cells in canine sinus grafting [J]. J Oral Pathol Med, 2017,46(7):528-536.
doi: 10.1111/jop.2017.46.issue-7
[21] Sohn DS, Heo JU, Kwak DH , et al. Bone regeneration in the maxillary sinus using an autologous fibrin-rich block with concentrated growth factors alone[J]. Implant Dent, 2011,20(5):389-395.
doi: 10.1097/ID.0b013e31822f7a70 pmid: 21881519
[22] Kim JM, Lee JH, Park IS . New bone formation using fibrin rich block with concentrated growth factors in maxillary sinus augmentation[J]. J Korean Assoc Oral Maxillofac Surg, 2011,37(4):278-286.
doi: 10.5125/jkaoms.2011.37.4.278
[23] Park IS, Sohn DS . Maxillary sinus elevation using concentrated growth factor (CGF)[J]. Int J Oral Ma-xillofac Surg, 2011,40(10):1133.
doi: 10.1016/j.ijom.2011.07.360
[24] Pirpir C, Yilmaz O, Candirli C , et al. Evaluation of effectiveness of concentrated growth factor on os-seointegration[J]. Int J Implant Dent, 2017,3(1):7.
doi: 10.1186/s40729-017-0069-3 pmid: 28258471
[25] Park SI, Bae HS, Hong KS . The biological effects of concentrated growth factors on the differentiation and proliferation of human gingival fibroblasts[J]. J Dent Hyg Sci, 2012,12(6):689-695.
[26] Yu BH, Wang ZL . Effect of concentrated growth factors on beagle periodontal ligament stem cells in vitro[J]. Mol Med Rep, 2014,9(1):235-242.
doi: 10.3892/mmr.2013.1756 pmid: 24173502
[27] 柳宏志, 邹高峰, 王天祥 , 等. 浓缩生长因子促进犬软组织损伤修复的实验研究[J]. 口腔颌面外科杂志, 2013,23(1):28-31.
doi: 10.3969/j.issn.1005-4979.2013.01.006
Liu HZ, Zou GF, Wang TX , et al. Concentrate growth factors in the promotion of healing of soft tissue wounds[J]. J Oral Maxillofac Surg, 2013,23(1):28-31.
doi: 10.3969/j.issn.1005-4979.2013.01.006
[28] Bozkurt Doğan Ş, öngöz Dede F, Ballı U , et al. Con-centrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth rando-mized clinical trial[J]. J Clin Periodontol, 2015,42(9):868-875.
doi: 10.1111/jcpe.12444 pmid: 26269089
[29] Uggeri J, Belletti S, Guizzardi S , et al. Dose-dependent effects of platelet gel releasate on activities of human osteoblasts[J]. J Periodontol, 2007,78(10):1985-1991.
doi: 10.1902/jop.2007.070116 pmid: 18062120
[30] Qin J, Wang L, Zheng L , et al. Concentrated growth factor promotes Schwann cell migration partly thr-ough the integrin β1-mediated activation of the focal adhesion kinase pathway[J]. Int J Mol Med, 2016,37(5):1363-1370.
doi: 10.3892/ijmm.2016.2520 pmid: 26986804
[31] Qin J, Wang L, Sun Y , et al. Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes func-tional nerve recovery in vivo[J]. Int J Mol Med, 2016,37(2):493-500.
doi: 10.3892/ijmm.2015.2438
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