国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (6): 640-645.doi: 10.7518/gjkq.2018.06.004

• RNA专栏 • 上一篇    下一篇

微小RNA调节间充质干细胞软骨分化机制的研究进展

冯顶丽1,2,卓丽丹2,芦笛3,郭红延2()   

  1. 1. 山西医科大学口腔医学院·口腔医院 太原 030001;
    2. 北京武警总医院口腔综合科 北京 100039
    3. 中国人民解放军总医院整形修复科 北京 100853
  • 收稿日期:2017-12-05 修回日期:2018-06-06 出版日期:2018-11-01 发布日期:2018-11-15
  • 通讯作者: 郭红延
  • 作者简介:冯顶丽,硕士,Email： 18234085075@163.com
  • 基金资助:
    国家自然科学基金(81571619);国家重点研发计划(2016YFE0204400)

Mechanism of microRNA modulation of cartilage differentiation in mesenchymal stem cells

Dingli Feng1,2,Lidan Zhuo2,Di Lu3,Hongyan Guo2()   

  1. 1. School and Hospital of Stomatology, Shanxi Medical University, Taiyuan 030001, China
    2. Dept. of Oral Medicine, Beijing Armed Police General Hospital, Beijing 100039, China
    3. Dept. of Orthopedics and Rehabilitation, General Hospital of PLA, Beijing 100853, China
  • Received:2017-12-05 Revised:2018-06-06 Online:2018-11-01 Published:2018-11-15
  • Contact: Hongyan Guo
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81571619);National Key Research and Development Plan(2016YFE0204400)

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摘要：

微小RNA（miRNA）主要通过不完全的碱基配对,在转录后水平调控基因的表达。在间充质干细胞软骨向分化过程中,有许多不同miRNA的表达,其对软骨分化起着重要的调节作用。近年来,miRNA具有成为软骨疾病治疗靶点的可能性,促进了研究人员强有力的调查,以求深入地了解miRNA在软骨发育中的作用机制。本文结合相关文献,对间充质干细胞软骨向分化过程中miRNA的表达及某些miRNA在调控软骨分化过程中的具体作用途径进行综述。

关键词: 微小RNA, 间充质干细胞, 软骨分化, 靶基因

Abstract:

microRNAs (miRNAs) regulate gene expression at the post-transcriptional level mainly through incomplete base-pairing. There are many different miRNA expressions in mesenchymal stem cells during the process of differentiation, and such expressions play an important role in the regulation of cartilage differentiation. In recent years, the possibility of miRNA becoming a target for the treatment of cartilage diseases has prompted researchers to investigate the role of miRNAs in the development of cartilage. In this paper, we review the expression of miRNAs during differentiation of mesenchymal stem cell cartilage and the specific roles of miRNAs in the process of cartilage differentiation.

Key words: microRNA, mesenchymal stem cell, cartilage differentiation, target gene

中图分类号: 

  • Q254
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