国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (4): 414-419.doi: 10.7518/gjkq.2018.04.008

• 综述 • 上一篇    下一篇

海藻酸-壳聚糖微球的制备及其在生物医药领域的应用

金鑫1, 杨军星1, 王英男2, 刘志辉1, 王博蔚3   

  1. 1.吉林大学口腔医院修复科 长春 130021;
    2.吉林大学化学学院 长春 130021;
    3.吉林大学第二医院妇产科 长春 130041
  • 收稿日期:2017-12-21 修回日期:2018-04-18 出版日期:2018-07-02 发布日期:2018-07-02
  • 通讯作者: 刘志辉,副教授,博士,Email：liuzhihui1975@sina.com
  • 作者简介:金鑫,住院医师,硕士,Email：441266577@qq.com
  • 基金资助:
    吉林省医药产业推进计划（20140311088YY）; 长春市重大科技攻关计划（2014054）; 吉林省科技攻关计划（20150204004YY）; 长春市“双十工程”计划（16SS12）

Preparation and biomedical applications of alginate-chitosan microspheres

Jin Xin1, Yang Junxing1, Wang Yingnan2, Liu Zhihui1, Wang Bowei3   

  1. 1. Dept. of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China;
    2. College of Chemistry, Jilin University, Changchun 130021, China;
    3. Dept. of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China
  • Received:2017-12-21 Revised:2018-04-18 Online:2018-07-02 Published:2018-07-02
  • Supported by:
    This study was supported by Pharmaceutical Industry Promotion Plan of Jilin Province (20140311088YY), Key Scientific and Technological Projects of Changchun City (2014054), Technology Research Program of Jilin Province (20150204004YY) and “Double Ten” Plan of Changchun City (16SS12).

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摘要： 壳聚糖是唯一的天然碱性氨基多糖,海藻酸是一种天然阴离子多聚糖,这两种物质都具有良好的生物相容性,无细胞毒性,具有生物可降解性,是制备微球的良好材料。本文综合阐述了近年来国内外联合利用壳聚糖和海藻酸两种天然高分子物质制备微球的主要方法（包括离子交联法和乳化法）,以及海藻酸-壳聚糖微球作为药物载体在生物医药领域的应用。

关键词: 壳聚糖, 海藻酸, 载药, 控释, 微球

Abstract: Chitosan is the only natural alkaline amino polysaccharide, and alginate is a kind of natural anionic polysac-charide. These polysaccharides are good materials for microsphere preparation because of their good biocompatibility, nontoxicity and biodegradability. This paper reviews the main methods (ion crosslinking and emulsification) of microsphere preparation by using the combination of chitosan and alginate and its application as a drug carrier in biomedicine.

Key words: chitosan, alginate, drug-loaded, control release, microsphere

中图分类号: 

  • R318.08
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