国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (1): 98-102.doi: 10.7518/gjkq.2017.01.020

• ·综述· • 上一篇    下一篇

辅助性T细胞亚群与牙周炎的免疫损伤机制

许丽华1, 许尧生2, 杨冬茹1   

  1. 1.河北医科大学口腔医院口腔内科 石家庄 050017;
    2.衡水哈励逊国际和平医院耳鼻喉科 衡水 050030
  • 收稿日期:2016-02-08 出版日期:2017-01-01 发布日期:2017-01-01
  • 通讯作者: 杨冬茹,主任医师,硕士,Email：dryang@hebmu.edu.cn
  • 作者简介:许丽华,博士,Email：xulh@hebmu.edu.cn

The role of help T cells in periodontal immunoresponses and tissue destruction

Xu Lihua1, Xu Yaosheng2, Yang Dongru1   

  1. 1. Dept. of Oral Medicine, Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China;
    2. Dept. of Otorhinolaryngology, Hengshui-Halisun International Peace Hospital, Hengshui 050030, China
  • Received:2016-02-08 Online:2017-01-01 Published:2017-01-01

RichHTML

6

PDF (PC)

393

被引次数

2

摘要： 牙周炎症组织破坏与机体针对致病菌及其毒性产物的免疫反应方式有关,辅助性T细胞（Th）亚群通过分泌不同的细胞因子发挥免疫调节功能。较早发现的Th1和Th2分别介导细胞免疫和体液免疫,二者相互抑制保持平衡,牙周炎症的间断性和进展性与Th1/Th2主导的免疫反应的平衡破坏有关。在牙周炎早期和静止期,表现为Th1反应类型;在牙周炎晚期或活动期,则表现为Th2反应类型。Th17具有重要的促进牙周慢性炎症及免疫损伤形成的作用,而调节性T细胞（Treg）则具有炎症抑制作用,而且Th17/Treg在功能和分化上也具有与Th1/Th2类似的相互调节相互抑制的平衡关系。Th17/Treg和Th1/Th2在局部形成复杂的细胞因子网络,是目前进一步研究牙周炎的免疫病理学机制的热点。

关键词: 牙周炎, 辅助性T细胞亚群, 免疫反应

Abstract: Periodontal tissue destruction in periodontitis is primarily caused by the immunoresponse and inflammation toward bacterial challenge. T helper(Th) cells are important for the cellular immunity of T cells. In particular, Th2 cells are important for the humoral immunity of B cells. Th1/Th2 is a pair of important effector T cells, which inhibit each other in function by the different cytokines they secrete and keep balance in normal conditions. Previous findings demonstrate that the different clinical manifestations of periodontitis at different periods are associated with Th1/Th2 imbalance. The early and stable period of periodontitis is dominated by Th1 immunoresponses, whereas the progressive period of the disease is dominated by Th2 immunoresponses. The recently found Th17 and regulatory T cell(Treg) are new T helper cell subsets. Th17 cells are associated with chronic periodontal inflammation and tissue destruction, whereas Treg cells are associated with the inhibition of inflammation. Similar to the case of Th1/Th2 balance pattern, Th17 and Treg are also closely related, and they balance each other both in terms of differentiation and functions. Th17/Treg and Th1/Th2 and their cytokines constitute a complicated cytokine network at the periodontal tissue. Their relationship with the progression and tissue destruction of periodontitis is currently undergoing extensive research.

Key words: periodontitis, help T cell, immunoresponses

中图分类号: 

  • Q256
[1] Gemmell E, Yamazaki K, Seymour GJ. Destructive periodontitis lesions are determined by the nature of the lymphocytic response[J]. Crit Rev Oral Biol Med, 2002, 13(1):17-34.
[2] Langrish CL, Chen Y, Blumenschein WM, et al. IL- 23 drives a pathogenic T cell population that induces autoimmune inflammation[J]. J Exp Med, 2005, 201 (2):233-240.
[3] Ito H, Honda T, Domon H, et al. Gene expression analysis of the CD4 + T-cell clones derived from gingival tissues of periodontitis patients[J]. Oral Microbiol Immunol, 2005, 20(6):382-386.
[4] Garlet GP. Destructive and protective roles of cyto-kines in periodontitis: a re-appraisal from host de-fense and tissue destruction viewpoints[J]. J Dent Res, 2010, 89(12):1349-1363.
[5] Stashenko P, Gonçalves RB, Lipkin B, et al. T h 1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis [J]. Am J Pa-thol, 2007, 170(1):203-213.
[6] Weaver CT, Hatton Rd, Mangan PR, et al. IL-17 family cytokines and the expanding diversity of effector T cell lineages[J]. Annu Rev Immunol, 2007, 25:821-852.
[7] Leech MT, Bartold PM. The association between rheumatoid and periodontitis[J]. Best Pract Res Clin Rheumatol, 2015, 29(2):189-201.
[8] Vernal R, Dutzan N, Chaparro A, et al. Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis[J]. J Clin Periodontol, 2005, 32(4):383-389.
[9] Johnson RB, Wood N, Serio FG. Interleukin-11 and IL-17 and the pathogenesis of periodontal disease[J]. J Periodontol, 2004, 75(1):37-43.
[10] 徐琛蓉, 赵川江, 吴颖. 广泛型侵袭性牙周炎患者龈沟液中白介素-17的检测[J]. 口腔医学, 2010, 30 (3):146-148. Xu CR, Zhao CJ, Wu Y. Levels of interleukin-17 in gingival crevicular fluid from patients with gene-ralized aggressive periodontitis[J]. Stomatology, 2010, 30(3):146-148.
[11] Weaver CT, Elson CO, Fouser LA, et al. The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin[J]. Annu Rev Pathol, 2013, 8:477- 512.
[12] 王琳源, 关宁, 林晓萍. 辅助性T17在牙周炎小鼠中的免疫状态研究[J]. 华西口腔医学杂志, 2015, 33(2):125-129. Wang LY, Guan N, Lin XP. Study on the immune status of T helper17 cells in mice with periodontitis [J]. West Chin J Stomatol, 2015, 33(2):125-129.
[13] Kramer JM, Gaffen SL. Interleukin-17: a new para-digm in inflammation, autoimmunity, and therapy[J]. J Periodontol, 2007, 78(6):1083-1093.
[14] 伍雪丽, 黄萍, 周学东. 白细胞介素-1B-511基因多态性与牙周炎进展的关系[J]. 华西口腔医学杂志, 2006, 24(6):523-526. Wu XL, Huang P, Zhou XD. Association of the progress of chronic periodontitis with interleukin-1b-511 genetic polymorphisms[J]. West Chin J Sto-matol, 2006, 24(6):523-526.
[15] Miossec P, Kolls JK. Targeting IL-17 and T H 17 cells in chronic inflammation[J]. Nat Rev Drug Discov, 2012, 11(10):763-776.
[16] Marton LJ, Kiss C. Overlapping protective and des-tructive regulatory pathways in apical periodontitis [J]. J Endodont, 2014, 40(2):155-163.
[17] Schmidt-Weber CB, Akdis M, Akdis CA. T H 17 cells in the big picture of immunology[J]. J Allergy Clin Immunol, 2007, 120(2):247-254.
[18] Yu JJ, Ruddy MJ, Wong GC, et al. An essential role for IL-17 in preventing pathogen-initiated bone des-truction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals[J]. Blood, 2007, 109(9):3794-3802.
[19] Hickman-Brecks CL, Racz JL, Meyer DM, et al. Th17 cells can provide B cell help in autoantibody induced arthritis[J]. J Autoimmun, 2011, 36(1):65- 75.
[20] Cardoso CR, Garlet GP, Moreira AP, et al. Charac-terization of CD4 + CD25 + natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis[J]. J Leukoc Biol, 2008, 84(1):311- 318.
[21] Parachuru VP, Coates DE, Milne TJ, et al. Forkhead box P3-positive regulatory T-cells and interleukin17-positive T-helper17 cells in chronic inflammatory periodontal disease[J]. J Periodont Res, 2014, 49(6): 817-826.
[22] 靳赢, 王琳源, 林晓萍. 实验性牙周炎中调节性T细胞的检测及免疫状态[J]. 上海口腔医学, 2013, 22 (5):487-491. Jin Y, Wang LY, Lin XP. Detection and the immune status of regulatory T cells in experimental periodon-titis[J]. Shanghai J Stomatol, 2013, 22(5):487-491.
[23] 靳赢, 林晓萍. 调节性T细胞及Th17与牙周骨吸收的研究进展[J]. 口腔医学, 2011, 31(12):757-759. Jin Y, Lin XP. Research progress on the regulation of T cells and Th17 cells and periodontal bone resorption[J]. Stomatology, 2011, 31(12):757-759.
[24] Kobayashi R, Kono T, Bolerjack BA, et al. Induction of IL-10-producing CD4 + T-cells in chronic perio-dontitis[J]. J Dent Res, 2011, 90(5):653-658.
[25] Nurieva R, Yang XO, Martinez G, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells[J]. Nature, 2007, 448(7152): 480-483.
[26] Zhou L, Ivanov II, Spolski R, et al. IL-6 programs T H -17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways[J]. Nat Immunol, 2007, 8(9):967-974.
[27] Tan Z, Jiang R, Wang X, et al. RORγt + IL-17 + neutro-phils play a critical role in hepatic ischemia-reper-fusion injury[J]. J Mol Cell Biol, 2013, 5(2):143- 146.
[28] Mantovani A, Cassatella MA, Costantini C, et al. Neutrophils in the activation and regulation of innate and adaptive immunity[J]. Nat Rev Immunol, 2011, 11(8):519-531.
[29] Afzali B, Lombardi G, Lechler RI, et al. The role of T helper17(Th17) and regulatory T cells(Treg) in human organ transplantation and autoimmune disease[J]. Clin Exp Immunol, 2007, 148(1):32-46.
[30] Eskan MA, Jotwani R, Abe T, et al. The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss[J]. Nat Immunol, 2012, 13 (5):465-473.
[31] Petermann F, Rothhammer V, Claussen MC, et al. γδ T cells enhance autoimmunity by restraining regula-tory T cell responses via an interleukin-23-dependent mechanism[J]. Immunity, 2010, 33(3):351-363.
[32] Konermann A, Beyer M, Deschner J, et al. Human periodontal ligment cells facillitate leuocyte recrute-ment and are influenced in their immunomodulatory function by Th17 cytokine release[J]. Cell Immunol, 2012, 272(2):137-143.
[33] Iwakura Y, Ishigame H, Saijo S, et al. Functional specialization of interleukin-17 family members[J]. Immunity, 2011, 34(2):149-162.
（本文采编 王晴）
[1] 傅豫, 何薇, 黄兰. 铁死亡在口腔疾病中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 36-44.
[2] 罗晓洁,王德续,陈晓涛. 基于生物信息学分析铁死亡调控基因与牙周炎的关系[J]. 国际口腔医学杂志, 2023, 50(6): 661-668.
[3] 黄元鸿,彭显,周学东. 骨碎补在治疗口腔骨相关疾病的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 679-685.
[4] 龚美灵,程兴群,吴红崑. 牙周炎与帕金森病相关性的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 587-593.
[5] 孙佳,韩烨,侯建霞. 白细胞介素-6-铁调素信号轴调控牙周炎相关性贫血致病机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 329-334.
[6] 刘体倩,梁星,刘蔚晴,李晓虹,朱睿. 咬合创伤在牙周炎发生发展中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 19-24.
[7] 李琼,于维先. 白藜芦醇治疗牙周炎及其生物利用度的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 25-31.
[8] 成益凡,秦旭,姜鸣,朱光勋. 牙周病中固有淋巴细胞的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 32-36.
[9] 黄伟琨,徐秋艳,周婷. 黄芩苷抑制脂多糖促巨噬细胞氧化应激损伤作用的研究[J]. 国际口腔医学杂志, 2022, 49(5): 521-528.
[10] 周剑鹏,谢旭东,赵蕾,王骏. 辅助性T细胞17及白细胞介素17在牙周炎中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 586-592.
[11] 陈荟宇,白明茹,叶玲. 信号素3A与口腔常见病关系的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 593-599.
[12] 周佳佳,赵蕾,徐欣. 牙周炎相关基因多态性的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 432-440.
[13] 马玉,左玉,张鑫. 光动力疗法辅助治疗牙周炎治疗效果的Meta分析[J]. 国际口腔医学杂志, 2022, 49(3): 305-316.
[14] 钱素婷,丁玲敏,纪雅宁,林军. 微小RNA在牙周炎龈沟液中的表达差异及对牙周炎的调控机制[J]. 国际口腔医学杂志, 2022, 49(3): 349-355.
[15] 蒋端,申道南,赵蕾,吴亚菲. 内皮发育调节基因-1与牙周炎相关性的研究进展[J]. 国际口腔医学杂志, 2022, 49(2): 244-248.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 王昆润. 二甲亚砜和双氯芬酸并用治疗根尖周炎[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 杨锦波. 嵌合体防龋疫苗的研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 王昆润. 下颔骨成形术用网状钛板固定植骨块[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 汪月月,郭莉莉. 口腔机能与老化—痴呆危险因素流行病学研究[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 丁刚. 应用硬组织代用品种植体行丰颏术[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 田磊. 局部应用脂多糖后结合上皮反应性增生的变化[J]. 国际口腔医学杂志, 1999, 26(04): .
[10] 戴青. 口腔念珠菌病的新分类[J]. 国际口腔医学杂志, 1999, 26(04): .