国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (3): 309-313.doi: 10.7518/gjkq.2016.03.013
李鑫,周进茹,李紫嫣,陈文川
Li Xin, Zhou Jinru, Li Ziyan, Chen Wenchuan
摘要: 生物医用材料是指以医疗为目的,用于修复或替换人体组织器官或增进其功能的材料。医学尤其是口腔医学的发展史是与医用材料的发展密切相关的,随着材料科学、生命科学和临床医学的不断发展,生物医用材料的研究也取得了很大的进步。新一代(第三代)生物医用材料因其良好的生物活性及生物降解性,在口腔医学领域得到了广泛应用,如骨组织工程支架材料、促进牙周组织再生的生物膜、运载药物的缓释载体等。本文就生物医用材料的发展历程以及第三代生物医用材料在口腔领域的应用研究进展作一综述,旨在使读者能够简单了解第三代生物医用材料的基本知识,并在此基础上为其在口腔医学领域的选择、应用提供参考。
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[1] Hench LL. Biomaterials[J]. Science, 1980, 208(4446):826-831. [2] Hench LL, Polak JM. Third-generation biomedical materials[J]. Science, 2002, 295(5557):1014-1017. [3] Shapoff CA, Alexander DC, Clark AE. Clinical use of a bioactive glass particulate in the treatment of human osseous defects[J]. Compend Contin Educ Dent, 1997, 18(4):352-358. [4] Hench LL, Xynos ID, Polak JM. Bioactive glasses for in situ tissue regeneration[J]. J Biomater Sci Polym Ed, 2004, 15(4):543-562. [5] Griffith LG, Naughton G. Tissue engineering—current challenges and expanding opportunities[J]. Science, 2002, 295(5557):1009-1014. [6] Levenberg S, Huang NF, Lavik E, et al. Differentiation of human embryonic stem cells on threedimensional polymer scaffolds[J]. Proc Natl Acad Sci USA, 2003, 100(22):12741-12746. [7] Venkatesan J, Kim SK. Chitosan composites for bone tissue engineering—an overview[J]. Mar Drugs, 2010, 8(8):2252-2266. [8] Pighinelli L, Kucharska M, Wísniewska-Wrona M, et al. Biodegradation study of microcrystalline chitosan and microcrystalline chitosan/β-TCP complex composites[J]. Int J Mol Sci, 2012, 13(6):7617-7628. [9] El-Kamel AH, Ashri LY, Alsarra IA. Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases [J]. AAPS PharmSciTech, 2007, 8(3):E75. [10] Barat R, Srinatha A, Pandit JK, et al. Chitosan inserts for periodontitis: influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release[J]. Acta Pharm, 2007, 57(4):469-477. [11] Ferrari PC, Souza FM, Giorgetti L, et al. Development and in vitro evaluation of coated pellets con taining chitosan to potential colonic drug delivery[J]. Carbohydr Polym, 2013, 91(1):244-252. [12] Ghasemi Tahrir F, Ganji F, Mani AR, et al. In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin[J]. Drug Deliv, 2016, 23(3):1038-1046. [13] Roller S, Covill N. The antimicrobial properties of chitosan in mayonnaise and mayonnaise-based shrimp salads[J]. J Food Prot, 2000, 63(2):202-209. [14] Arancibia R, Maturana C, Silva D, et al. Effects of chitosan particles in periodontal pathogens and gingival fibroblasts[J]. J Dent Res, 2013, 92(8):740-745. [15] Chudobova D, Nejdl L, Gumulec J, et al. Complexes of silver(I) ions and silver phosphate nanoparticles with hyaluronic acid and/or chitosan as promising antimicrobial agents for vascular grafts[J]. Int J Mol Sci, 2013, 14(7):13592-13614. [16] Di Giulio M, Di Bartolomeo S, Di Campli E, et al. The effect of a silver nanoparticle polysaccharide system on streptococcal and saliva-derived biofilms [J]. Int J Mol Sci, 2013, 14(7):13615-13625. [17] Park JS, Choi SH, Moon IS, et al. Eight-week histological analysis on the effect of chitosan on surgically created one-wall intrabony defects in beagle dogs[J]. J Clin Periodontol, 2003, 30(5):443-453. [18] Liao F, Chen Y, Li Z, et al. A novel bioactive threedimensional beta-tricalcium phosphate/chitosan scaffold for periodontal tissue engineering[J]. J Mater Sci Mater Med, 2010, 21(2):489-496. [19] Lee JS, Baek SD, Venkatesan J, et al. In vivo study of chitosan-natural nano hydroxyapatite scaffolds for bone tissue regeneration[J]. Int J Biol Macromol, 2014, 67:360-366. [20] Park H, Choi B, Nguyen J, et al. Anionic carbohydrate-containing chitosan scaffolds for bone regeneration[J]. Carbohydr Polym, 2013, 97(2):587-596. [21] Zhang Y, Shi B, Li C, et al. The synergetic boneforming effects of combinations of growth factors expressed by adenovirus vectors on chitosan/collagen scaffolds[J]. J Control Release, 2009, 136(3):172-178. [22] Kemp PD. Tissue engineering and cell-populated collagen matrices[J]. Methods Mol Biol, 2009, 522:363-370. [23] Lee CH, Singla A, Lee Y. Biomedical applications of collagen[J]. Int J Pharm, 2001, 221(1/2):1-22. [24] Wong Po Foo C, Kaplan DL. Genetic engineering of fibrous proteins: spider dragline silk and collagen[J]. Adv Drug Deliv Rev, 2002, 54(8):1131-1143. [25] Güng?rmü? M, Kaya O. Evaluation of the effect of heterologous typeⅠcollagen on healing of bone defects[J]. J Oral Maxillofac Surg, 2002, 60(5):541-545. [26] Sumita Y, Honda MJ, Ohara T, et al. Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering[J]. Biomaterials, 2006, 27(17):3238-3248. [27] Su CC, Kao CT, Hung CJ, et al. Regulation of physicochemical properties, osteogenesis activity, and fibroblast growth factor-2 release ability of β-tricalcium phosphate for bone cement by calcium silicate [J]. Mater Sci Eng C Mater Biol Appl, 2014, 37:156-163. [28] Duncan J, Macdonald JF, Hanna JV, et al. The role of the chemical composition of monetite on the synthesis and properties of α-tricalcium phosphate [J]. Mater Sci Eng C Mater Biol Appl, 2014, 34:123-129. [29] Gronthos S, Brahim J, Li W, et al. Stem cell properties of human dental pulp stem cells[J]. J Dent Res, 2002, 81(8):531-535. [30] Levin MP, Getter L, Cutright DE, et al. Biodegradable ceramic in periodontal defects[J]. Oral Surg Oral Med Oral Pathol, 1974, 38(3):344-351. [31] Hossain MZ, Yamada T, Yamauchi K. Biodegradable ceramic as a bone graft substitute followed by orthodontic tooth movement[J]. Nihon Kyosei Shika Gakkai Zasshi, 1989, 48(5):483-495. [32] Hu J, Zhou Y, Huang L, et al. Effect of nanohydroxyapatite coating on the osteoinductivity of porous biphasic calcium phosphate ceramics[J]. BMC Musculoskelet Disord, 2014, 15:114. |
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