国际口腔医学杂志

国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (3): 295-297.doi: 10.7518/gjkq.2016.03.010

• 综述 • 上一篇    下一篇

低龄儿童龋微生物群落的研究进展

黄慧,张琼,邹静   

  1. 口腔疾病研究国家重点实验室 华西口腔医院儿童口腔科（四川大学） 成都 610041
  • 收稿日期:2015-07-09 修回日期:2015-01-28 出版日期:2016-05-01 发布日期:2016-05-01
  • 通讯作者: 邹静，教授，博士，Email：zoujing1970@126.com
  • 作者简介:黄慧，硕士，Email：354189929@qq.com

Research progress on oral microbiota of early childhood caries

Huang Hui, Zhang Qiong, Zou Jing   

  1. State Key Laboratory of Oral Diseases, Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)
  • Received:2015-07-09 Revised:2015-01-28 Online:2016-05-01 Published:2016-05-01

RichHTML

12

PDF (PC)

757

摘要： 低龄儿童龋（ECC）的发生发展不仅仅是某几种特定致龋菌作用的结果，而是与整个口腔微生物群落的变化有关。在健康的生理状况下，口腔微生物群与宿主间保持着一种动态平衡，共同维系宿主的健康；若这种平衡若遭到破坏，口腔内某些健康的微生物将转变成致病微生物，导致龋病、牙周病和黏膜病等口腔感染性疾病。个体与个体之间，同一个体唾液和牙菌斑之间，微生物种群明显不同。无龋儿童的细菌多样性和复杂性高于重症低龄龋（SECC）儿童，而SECC儿童在龋发生前微生物多样性呈下降趋势，即龋病可能与微生物多样性降低相关。ECC儿童在治疗前后，其微生物群落构成会发生明显改变。益生菌可抑制致龋菌的活性，降低患龋率。了解口腔微生物菌群组的结构和组成，建立不同患龋风险儿童的微生物图谱，控制与管理儿童口腔微生态，ECC的防治将会呈现出一片曙光。

关键词: 低龄儿童龋, 微生态, 口腔微生物群, 低龄儿童龋, 微生态, 口腔微生物群

Abstract: Not only several selected bacteria but also oral microbiota are closely related to the initiation and progression of early childhood caries(ECC). Oral microbes and the host are in a dynamic balance in normal physiological conditions; however, this varying balance ultimately determines oral infectious disease. Microbiota varies between individual, plaque, and saliva. The microbial diversity of caries-free children is higher than that of severe ECC(SECC) children, and it decreases before caries appears, that is, the caries may be associated with the decrease of microbial diversity. Microbiota composition of SECC children significantly changes post-therapy. Probiotics can decrease the number of cariogenic bacteria and prevalence rate of caries. Learning more about children’s oral microbiota will provide higher predictability of ECC development and lead to the implementation of targeted early intervention. This review focuses on recent microbiological findings about ECC-associated microbiota.

Key words: early childhood caries, microecology, oral microbiota, early childhood caries, microecology, oral microbiota

中图分类号: 

  • R 780.2
[1] Almeida AG, Roseman MM, Sheff M, et al. Future caries susceptibility in children with early childhood caries following treatment under general anesthesia [J]. Pediatr Dent, 2000, 22(4):302-306.
[2] Marsh PD. Dental diseases—are these examples of ecological catastrophes[J]. Int J Dent Hyg, 2006, 4 (Suppl 1):3-10.
[3] 周学东, 施文元. 人体口腔微生物组群与牙菌斑生物膜[J]. 华西口腔医学杂志, 2010, 28(2):115-118.
Zhou XD, Shi WY. Human oral microbial community and dental plaque biofilm[J]. West China J Stomatol, 2010, 28(2):115-118.
[4] Ling Z, Kong J, Jia P, et al. Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencing[J]. Microb Ecol, 2010, 60(3):677-690.
[5] Li Y, Ge Y, Saxena D, et al. Genetic profiling of the oral microbiota associated with severe early-childhood caries[J]. J Clin Microbiol, 2007, 45(1):81-87.
[6] Tao Y, Zhou Y, Ouyang Y, et al. Dynamics of oral microbial community profiling during severe early childhood caries development monitored by PCRDGGE[J]. Arch Oral Biol, 2013, 58(9):1129-1138.
[7] Becker MR, Paster BJ, Leys EJ, et al. Molecular analysis of bacterial species associated with childhood caries[J]. J Clin Microbiol, 2002, 40(3):1001-1009.
[8] Klein MI, Flório FM, Pereira AC, et al. Longitudinal study of transmission, diversity, and stability of Streptococcus mutans and Streptococcus sobrinus genotypes in Brazilian nursery children[J]. J Clin Microbiol, 2004, 42(10):4620-4626.
[9] Alaluusua S, M?tt? J, Gr?nroos L, et al. Oral colonization by more than one clonal type of Mutans streptococcus in children with nursing-bottle dental caries[J]. Arch Oral Biol, 1996, 41(2):167-173.
[10] Zhou Q, Qin X, Qin M, et al. Genotypic diversity of Streptococcus mutans and Streptococcus sobrinus in 3-4-year-old children with severe caries or without caries[J]. Int J Paediatr Dent, 2011, 21(6):422-431.
[11] Kreulen CM, de Soet HJ, Hogeveen R, et al. Streptococcus mutans in children using nursing bottles[J]. ASDC J Dent Child, 1997, 64(2):107-111.
[12] Tanner AC, Kent RL, Holgerson PL, et al. Microbiota of severe early childhood caries before and after therapy[J]. J Dent Res, 2011, 90(11):1298-1305.
[13] Klinke T, Urban M, Lück C, et al. Changes in Candida spp., mutans streptococci and lactobacilli following treatment of early childhood caries: a 1-year follow-up[J]. Caries Res, 2014, 48(1):24-31.
[14] Fazilat S, Sauerwein R, McLeod J, et al. Application of adenosine triphosphate-driven bioluminescence for quantification of plaque bacteria and assessment of oral hygiene in children[J]. Pediatr Dent, 2010, 32(3):195-204.
[15] Doron S, Gorbach SL. Probiotics: their role in the treatment and prevention of disease[J]. Expert Rev Anti Infect Ther, 2006, 4(2):261-275.
[16] Petti S, Tarsitani G, D’Arca AS. A randomized clinical trial of the effect of yoghurt on the human salivary microflora[J]. Arch Oral Biol, 2001, 46(8):705-712.
[17] S?nmez IS, Aras S. Effect of white cheese and sugarless yoghurt on dental plaque acidogenicity[J]. Caries Res, 2007, 41(3):208-211.
[18] N?se L, Hatakka K, Savilahti E, et al. Effect of longterm consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children[J]. Caries Res, 2001, 35(6):412-420.
（本文采编 王晴）
[1] 高若凡,夏斌. 基于慢性疾病管理理念的重度低龄儿童龋管理方法[J]. 国际口腔医学杂志, 2023, 50(3): 341-346.
[2] 朱锦怡,樊琪,周媛,邹静,黄睿洁. 唾液蛋白作为低龄儿童龋预测标志物的研究进展[J]. 国际口腔医学杂志, 2022, 49(2): 212-219.
[3] 李诗佳,陈秋宇,邹静,黄睿洁. 尼古丁对口腔细菌单独或混合培养时菌群数目调控的研究[J]. 国际口腔医学杂志, 2021, 48(3): 305-311.
[4] 杨志雷,刘宝盈. 龋病牙菌斑微生态研究进展[J]. 国际口腔医学杂志, 2020, 47(5): 506-514.
[5] 郏乐铭,贾小玥,杨燃,周学东,徐欣. 益生菌制剂在牙周病防治中的应用进展[J]. 国际口腔医学杂志, 2020, 47(5): 515-521.
[6] 邓晓宇,张蕴涵,邹静. 低龄儿童龋的早期生物学管理[J]. 国际口腔医学杂志, 2020, 47(5): 581-588.
[7] 杜倩,任彪,周学东,徐欣. 根面龋微生态的研究进展[J]. 国际口腔医学杂志, 2019, 46(3): 326-332.
[8] 郑黎薇, 邹静, 夏斌, 刘英群, 黄洋, 赵今. 儿童乳磨牙金属预成冠的修复治疗[J]. 国际口腔医学杂志, 2017, 44(2): 125-129.
[9] 邹静1 秦满2 汪俊3 黄华4 林居红5 周学东. 儿童常见牙病与错牙合畸形[J]. 国际口腔医学杂志, 2016, 43(6): 619-623.
[10] 胡永啸 谢志刚. 牙周病微生态改善疗法的研究进展[J]. 国际口腔医学杂志, 2013, 40(3): 326-329.
[11] 石晶1，2综述 彭惠1审校. 自锁托槽与传统托槽对牙周环境影响的研究现状和进展[J]. 国际口腔医学杂志, 2012, 39(6): 824-827.
[12] 杨晓琼1综述 邹静2审校. 低龄儿童龋与其相关致病菌的研究进展[J]. 国际口腔医学杂志, 2011, 38(4): 455-459.
[13] 孟庆伟综述 赵尔扬审校. 牙周炎致病菌的变性梯度凝胶电泳检测[J]. 国际口腔医学杂志, 2009, 36(5): 547-549.
[14] 刘源综述 周学东审校. 变异链球菌的微生态学研究进展[J]. 国际口腔医学杂志, 2008, 35(5): 502-502～506.
[15] 董聪综述 张富强审校. 可摘局部义齿对口腔微生态系的影响[J]. 国际口腔医学杂志, 2008, 35(1): 71-73.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 王昆润. 二甲亚砜和双氯芬酸并用治疗根尖周炎[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 杨锦波. 嵌合体防龋疫苗的研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 王昆润. 下颔骨成形术用网状钛板固定植骨块[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 汪月月,郭莉莉. 口腔机能与老化—痴呆危险因素流行病学研究[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 丁刚. 应用硬组织代用品种植体行丰颏术[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 田磊. 局部应用脂多糖后结合上皮反应性增生的变化[J]. 国际口腔医学杂志, 1999, 26(04): .
[10] 戴青. 口腔念珠菌病的新分类[J]. 国际口腔医学杂志, 1999, 26(04): .