动物试验,纳米羟磷灰石/聚酰胺-66,牙种植体," /> 动物试验,纳米羟磷灰石/聚酰胺-66,牙种植体,"/> animal experiment, nano-hydroxyapatite/polyamide-66,
dental implant,"/> 纳米羟磷灰石/聚酰胺-66 牙种植体的动物试验
国际口腔医学杂志

国际口腔医学杂志 ›› 2010, Vol. 37 ›› Issue (6): 629-633.doi: 10.3969/j.issn.1673-5749.2010.06.003

• 论著 • 上一篇    下一篇

纳米羟磷灰石/聚酰胺-66 牙种植体的动物试验

李万山，代静波，钟渝翔，梁丽，廖礼姝，李远贵，魏世成   

  1. 1.重庆医科大学附属儿童医院口腔科 重庆 400014；2.重庆市八益牙科大坪口腔门诊部 重庆 400020；3.北京大学口腔医院口腔颌面外科 北京 100081
  • 出版日期:2010-11-20 发布日期:2010-11-20
  • 通讯作者: 魏世成，Tel：010-62753404

Animal experimental study of nano-hydroxyapatite/polyamide-66 dental implantation

LI Wan-shan1, DAI Jing-bo2, ZHONG Yu-xiang1, LIANG Li1, LIAO Li-shu1, LI Yuan-gui1, WEI Shi-cheng3.   

  1. 1. Dept. of Stomatology, Children’s Hospital of
    Chongqing Medical University, Chongqing 400014, China; 2. Daping Stomatological
    Clinic, Bayi Dental Department of Chongqing, Chongqing 400020, China; 3. Dept.
    of Oral and Maxillofacial Surgery, School of Stomatology, Peking University,
    Beijing 100081, China
  • Online:2010-11-20 Published:2010-11-20

RichHTML

3

PDF (PC)

974

摘要：

目的 探讨纳米羟磷灰石/聚酰胺-66（nHA/PA-66）复合牙种植体的动物试验结果及临床可行性。方法 将nHA/PA-66复合牙种植体随机植入5只成年杂种犬前牙区新鲜拔牙创内，定期处死动物，获取其上下颌骨标本，进行局部X线和苏木精-伊红染色检查。结果 术中共拔除前牙23颗，植入种植体13枚，术后除1枚于8周时脱落外，其余种植体良好存在。种植体与牙槽骨间间隙无明显增宽或变窄，间隙内有结缔组织形成且随时间延长逐渐增多、排列方向发生改变。结论 nHA/PA-66种植体植入犬新鲜拔牙创后，在种植体与牙槽骨间可形成随时间推移数量增多、排列改变的结缔组织。这些结缔组织到底是种植体周围的纤维包裹还是来源于拔牙创内的健康牙周膜，有待进一步研究。

关键词: 动物试验')">动物试验, 纳米羟磷灰石/聚酰胺-66')">纳米羟磷灰石/聚酰胺-66, 牙种植体')">牙种植体

Abstract:

Objective
 The aim of this study was to evaluate
the clinical applicability of the dental implant made of
nano-hydroxyapatite/polyamide-66（nHA/PA-66） composite according to the animal experiment. Methods  13 implants, which were made of nHA/PA-66
composite, were randomly implanted into the fresh tooth extraction wound in the
anterior teeth region of five adult mongrel dogs. The five dogs were sacrificed
singly at 4, 8, 12, 16 and 20 weeks postoperatively. Histological and
radiographical analyses were performed after the animals were sacrificed. Results  In addition to one implant fallen off after 8
weeks, the rest of the 12 plants existed well. X ray examination, the gaps
between the implant and alveolar bone were no significant broadening or
narrowing. Hematoxylin-eosin staining histological examination, there were
connective tissues formed in the gaps. We also found that its quantity
gradually increased and its orientating changed over time. Conclusion  The study
confirmed that the connective tissues formed in the gaps between the implant
and alveolar bone. We wonder that the connective tissues came from healthy
periodontium of alveolar fossa or fiber wrapping surrounding the implants. The
further study should be continued.

Key words: animal experiment')">animal experiment, nano-hydroxyapatite/polyamide-66')"> nano-hydroxyapatite/polyamide-66,
dental implant')">
dental implant

No related articles found!
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 张京剧. 青年期至中年期颅面复合体变化的头影测量研究[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 刘玲. 镍铬合金中铍对可铸造性和陶瓷金属结合力的影响[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 王昆润. 在种植体上制作固定义齿以后下颌骨密度的动态变化[J]. 国际口腔医学杂志, 1999, 26(06): .
[4] 王昆润. 重型颌面部炎症死亡和康复病例的实验室检查指标比较[J]. 国际口腔医学杂志, 1999, 26(06): .
[5] 逄键梁. 两例外胚层发育不良儿童骨内植入种植体后牙槽骨生长情况[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 温秀杰. 氟化物对牙本质脱矿抑制作用的体外实验研究[J]. 国际口腔医学杂志, 1999, 26(05): .
[7] 杨春惠. 耳颞神经在颞颌关节周围的分布[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 王昆润. 牙周炎加重期应选用何种抗生素[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 杨儒壮 孙宏晨 欧阳喈. 纳米级高分子支架材料在组织工程中的研究进展[J]. 国际口腔医学杂志, 2004, 31(02): 126 -128 .
[10] 严超然,李龙江. 肿瘤靶向药物载体系统的研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .