国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (4): 450-458.doi: 10.7518/gjkq.2021065

• 综述 • 上一篇    下一篇

人乳头状瘤病毒16相关口咽鳞状细胞癌独特生物学行为及治疗的研究现状

王岳1,2(),季一鸣1,2,王晓毅3,张凌楠4,孙乐刚1,2()   

  1. 1.滨州医学院附属医院口腔颌面外科 滨州 256600
    2.滨州医学院口腔医学院 烟台 264010
    3.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院头颈肿瘤外科 成都 610041
    4.滨州医学院附属医院口腔正畸科 滨州 256600
  • 收稿日期:2020-11-22 修回日期:2021-03-20 出版日期:2021-07-01 发布日期:2021-06-30
  • 通讯作者: 孙乐刚
  • 作者简介:王岳,硕士,Email: 17862890372@163.com
  • 基金资助:
    山东省自然科学基金博士基金(ZR2018BH026);山东省医药卫生科技发展计划面上项目(2017WS231);滨州市社会科学规划重点研究课题(19-SKGH-31)

Unique biological behavior and treatment of the human papilloma virus 16-related oropharyngeal squamous cell carcinoma

Wang Yue1,2(),Ji Yiming1,2,Wang Xiaoyi3,Zhang Lingnan4,Sun Legang1,2()   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China
    2. School of Stomatology, Binzhou Medical University, Yantai 264010, China
    3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    4. Dept. of Orthodontics, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China
  • Received:2020-11-22 Revised:2021-03-20 Online:2021-07-01 Published:2021-06-30
  • Contact: Legang Sun
  • Supported by:
    Natural Science Foundation of Shandong Province(ZR2018BH026);Development Plan of Medical and Health Science and Technology in Shandong Province(2017WS231);Binzhou Social Science Planning Key Research Project(19-SKGH-31)

摘要:

人乳头状瘤病毒(HPV)感染是口咽鳞状细胞癌(OPSCC)除吸烟、饮酒外第3个独立的致病因素。其中,高危型HPV16在OPSCC发生发展中起着不可替代的重要作用,因HPV16相关OPSCC具有独特的临床病理特征,其预后及治疗方法与其他类型的OPSCC有着明显的不同。在原有治疗方法的基础上,延伸出经口腔内窥镜手术技术、放射和化学治疗、免疫治疗、疫苗预防等更为优良的治疗方法,本文主要围绕HPV16相关OPSCC独特的临床病理特征及治疗方法进行阐述。

关键词: 人乳头状瘤病毒, 口咽鳞状细胞癌, 独特临床病理特征, 治疗

Abstract:

Human papilloma virus (HPV) infection is the third-largest independent etiological factor causing orophar-yngeal squamous cell carcinoma (OPSCC) apart from smoking and drinking. High-risk HPV16 plays an important role in the occurrence and development of OPSCC. Considering its unique clinicopathologic features, the prognosis and treatment methods for HPV16-related OPSCC are significantly different from those for traditional OPSCC. Based on the original treatment methods, transoral endoscopic surgery, radiochemotherapy, immunotherapy, and vaccine treatment are extended. This paper focuses on the unique clinicopathologic features and treatment methods of HPV16-related OPSCC.

Key words: human papilloma virus, oropharyngeal squamous cell carcinoma, unique clinicopathologic features, treatment

中图分类号: 

  • R739.8

图1

HPV16的致癌机制 EGFR:表皮生长因子受体(epidermal growth factor receptor);Cyclin D1:细胞周期蛋白D1。"

表 1

HPV16不同感染状态下OPSCC的临床病理特征"

临床病理特征 HPV16相关OPSCC 传统OPSCC
发病率 增加 减少
病因 吸烟、饮酒、HPV感染 吸烟、饮酒
发病年龄 年轻化 可发于任何年龄,中老年多见
发病部位 扁桃体、舌根部 口咽部任何部位,甚至波及其他部位
症状 无明显疼痛、仅出现颈部的囊性肿大 咽喉部疼痛、吞咽异物感
淋巴结转移 早期可出现转移 任何时期均可能转移
预后 较好
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