国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (2): 146-151.doi: 10.7518/gjkq.2020020

• 牙周专栏 • 上一篇    下一篇

不同干细胞来源外泌体在牙周再生领域的研究进展

吴晓楠1,马宁2,侯建霞3()   

  1. 1. 青岛市口腔医院牙周科 青岛 266001
    2. 青岛市市立医院东院区口腔科 青岛 266071
    3. 北京大学口腔医院牙周科 北京 100081
  • 收稿日期:2019-06-04 修回日期:2019-11-29 出版日期:2020-03-01 发布日期:2020-03-12
  • 通讯作者: 侯建霞
  • 作者简介:吴晓楠,医师,硕士,Email: wxn6128@163.com
  • 基金资助:
    青岛市卫生科技发展计划项目(2017-WJZD123)

Research progress of exosomes derived from different stem cells in periodontal regeneration

Wu Xiaonan1,Ma Ning2,Hou Jianxia3()   

  1. 1. Dept. of Periodontology, Qingdao Stomatological Hospital, Qingdao 266001, China
    2. Dept. of Stomatology, Qingdao Municipal Hospital, Qingdao 266071, China
    3. Dept. of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China
  • Received:2019-06-04 Revised:2019-11-29 Online:2020-03-01 Published:2020-03-12
  • Contact: Jianxia Hou
  • Supported by:
    This study was supported by Qingdao Health Science and Technology Development(2017-WJZD123)

摘要:

牙周炎是由牙菌斑中的微生物所引起的慢性感染性疾病,可引起牙周支持组织的炎症和破坏,是成年人失牙的最主要原因。良好的菌斑控制可有效抑制炎症进展,然而目前在临床诊疗中,尚难以获得稳定的、令人满意的牙周组织再生。外泌体是真核细胞分泌的一种细胞外膜性微囊泡,可作为干细胞旁分泌活动的一种重要形式参与多种组织的再生。外泌体的应用为牙周组织再生提供了一种新策略,本文对不同干细胞来源外泌体在牙周再生领域的研究进展进行综述。

关键词: 外泌体, 牙周再生, 间充质干细胞

Abstract:

Periodontitis is a chronic infectious disease caused by dental plaque and the primary reason for tooth loss in adults because it damages periodontal supporting structures. Microbial plaque biofilm control is an effective method to prevent further disease progression. However, a reliable treatment that can lead to stable and satisfactory periodontal regeneration in clinical practice has not been reported to date. Exosome is a specific class of lipid-membrane-bound extracellular vesicle. Exosomes are secreted from cells through paracrine mechanism and participate in tissue regeneration. Considering that the application of exosomes provides a new strategy for tissue regeneration, this review presents the current status of exosomes derived from different kinds of cells for potential therapeutic use in periodontal regeneration.

Key words: exosome, periodontal regeneration, mesenchymal stem cell

中图分类号: 

  • Q756
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