国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (1): 51-57.doi: 10.7518/gjkq.2020030

• 口腔黏膜专栏 • 上一篇    下一篇

口腔苔藓样病变的研究进展

陈煜鑫,周瑜(),陈谦明   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院口腔黏膜病科 成都 610041
  • 收稿日期:2019-03-19 修回日期:2019-09-28 出版日期:2020-01-01 发布日期:2020-01-01
  • 通讯作者: 周瑜
  • 作者简介:陈煜鑫,硕士,Email: 469798051@qq.com
  • 基金资助:
    国家自然科学基金(81470747);国家自然科学基金(81771086)

Research progress on oral lichenois lesions

Chen Yuxin,Zhou Yu(),Chen Qianming   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-03-19 Revised:2019-09-28 Online:2020-01-01 Published:2020-01-01
  • Contact: Yu Zhou
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81470747);This study was supported by National Natural Science Foundation of China(81771086)

摘要:

口腔苔藓样病变(OLL)是一种与口腔扁平苔藓(OLP)极其相似的疾病,近年来,随着人们物质生活和医疗保健水平的提高,越来越多的患者接受了义齿修复、器官移植、化学治疗等医疗服务,使得OLL的患病率日趋升高。本文将近年来有关OLL的最新研究进展作一综述,以期能帮助口腔医生更加全面深入地认识这类疾病。

关键词: 口腔苔藓样病变, 临床表现, 组织病理学, 潜在恶性疾患

中图分类号: 

  • R781.5

表 1

OLP与OLL的鉴别"

项目 OLP OLL
病因 病因不明,可能与免疫因素、精神因素、内分泌因素、感染因素、微循环障碍因素、遗传因素、糖尿病等相关 汞合金修复体及其他口腔接触材料;某些药物;移植物抗宿主病等
发病机制 T细胞介导的免疫反应 迟发型超敏反应
组织病理 上皮过度不全角化;基底细胞液化变性;固有层密集的淋巴细胞呈带状浸润 上皮局灶性角化不全;淋巴细胞可弥漫性浸润于固有层及黏膜下层;炎症细胞有向血管聚集的趋势
免疫病理 基底膜区纤维蛋白原强荧光带 基底膜区弱而均一线性荧光染色
临床表现 通常双侧对称发生;可发生于口腔黏膜任何部位,以颊部最为多见 通常单侧发生;常多发于金属修复体邻近部位
潜在恶变性[45,49,66] 0.4%~2%[67] 2.1%~2.5%
治疗 心理治疗;药物治疗;手术治疗;光动力疗法 着重明确并去除可疑致病因素,余治疗手段同OLP
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