国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (5): 617-620.doi: 10.7518/gjkq.2019055

• 综述 • 上一篇    

唇腭裂患者的脑部结构与功能研究进展

邓程丹,石冰,李杨()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院唇腭裂外科 成都 610041
  • 收稿日期:2018-10-02 修回日期:2019-04-25 出版日期:2019-09-01 发布日期:2019-09-10
  • 通讯作者: 李杨
  • 作者简介:邓程丹,硕士,Email: 945060568@qq.com
  • 基金资助:
    国家自然科学基金青年基金(30900391)

Research progress on the brain structure and function of patients with cleft lip and palate

Deng Chengdan,Shi Bing,Li Yang()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-10-02 Revised:2019-04-25 Online:2019-09-01 Published:2019-09-10
  • Contact: Yang Li
  • Supported by:
    This study was supported by National Natural Science Foundation of China(30900391)

摘要:

非综合型唇腭裂是常见多发的先天性疾病之一,在明显的面部畸形以外,有研究表明唇腭裂患者的脑部结构与正常人也有差异。随着检测技术的发展,这些先进的检测技术越来越多地应用于唇腭裂患者脑部的研究。本文对唇腭裂患者的大脑结构与功能的研究进展作一综述,以便于深入理解及研究唇腭裂患者与正常人的大脑结构与功能差异。

关键词: 唇腭裂, 大脑结构, 功能, 磁共振成像

Abstract:

Cleft lip and cleft palate are highly common congenital disabilities. In addition to the obvious facial deformity, the brain of a patient with cleft lip and palate differs from that of a normal person. The development of advanced detection technologies is enabling detailed studies on the brain of patients with cleft lip and palate. This article reviews the progress of research on such patients’ brain to examine and understand their brain structures and functions.

Key words: cleft lip and palate, brain structure, function, magnetic resonance imaging

中图分类号: 

  • R782.2
[1] de Milly MN, Alison M, Arthurs O , et al. Is fetal cerebral MRI worthwhile in antenatally diagnosed isolated cleft lip with or without palate[J]. Prenat Diagn, 2013,33(3):273-278.
[2] Rosen H, Chiou GJ, Stoler JM , et al. Magnetic resonance imaging for detection of brain abnormalities in fetuses with cleft lip and/or cleft palate[J]. Cleft Palate Craniofac J, 2011,48(5):619-622.
[3] 束煌, 杨峰, 丁桂聪 , 等. 唇腭裂患儿高级听觉中枢的MRI形态学研究[J]. 临床口腔医学杂志, 2012,28(7):430-432.
Shu H, Yang F, Ding GC , et al. A MRI study of auditory center of infants with cleft lip and/or palate[J]. J Clin Stomatol, 2012,28(7):430-432.
[4] Yang FF , McPherson B, Shu H, et al. Structural abnormalities of the central auditory pathway in infants with nonsyndromic cleft lip and/or palate[J]. Cleft Palate Craniofac J, 2012,49(2):137-145.
[5] Adamson CL, Anderson VA, Nopoulos P , et al. Regional brain morphometric characteristics of nonsyndromic cleft lip and palate[J]. Dev Neurosci, 2014,36(6):490-498.
[6] Weinberg SM, Andreasen NC, Nopoulos P . Three-dimensional morphometric analysis of brain shape in nonsyndromic orofacial clefting[J]. J Anat, 2009,214(6):926-936.
[7] Weinberg SM, Parsons TE, Fogel MR , et al. Corpus callosum shape is altered in individuals with nonsyndromic cleft lip and palate[J]. Am J Med Genet A, 2013,161A(5):1002-1007.
[8] Chollet MB , DeLeon VB, Conrad AL, et al. Morphometric analysis of brain shape in children with nonsyndromic cleft lip and/or palate[J]. J Child Neurol, 2014,29(12):1616-1625.
[9] Conrad AL, Dailey S, Richman L , et al. Cerebellum structure differences and relationship to speech in boys and girls with nonsyndromic cleft of the lip and/or palate[J]. Cleft Palate Craniofac J, 2010,47(5):469-475.
[10] DeVolder I, Richman L, Conrad AL , et al. Abnormal cerebellar structure is dependent on phenotype of isolated cleft of the lip and/or palate[J]. Cerebellum, 2013,12(2):236-244.
[11] van der Plas E, Caspell CJ, Aerts AM , et al. Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate[J]. Pediatr Res, 2012,71(5):612-618.
[12] Boes AD, Murko V, Wood JL , et al. Social function in boys with cleft lip and palate: relationship to ventral frontal cortex morphology[J]. Behav Brain Res, 2007,181(2):224-231.
[13] Nopoulos P, Choe I, Berg S , et al. Ventral frontal cortex morphology in adult males with isolated orofacial clefts: relationship to abnormalities in social function[J]. Cleft Palate Craniofac J, 2005,42(2):138-144.
[14] Nopoulos P, Boes AD, Jabines A , et al. Hyperactivity, impulsivity, and inattention in boys with cleft lip and palate: relationship to ventromedial prefrontal cortex morphology[J]. J Neurodev Disord, 2010,2(4):235-242.
[15] Gassling V, Receveur K, Niederberger U , et al. No deficit in neurocortical information processing in patients with cleft lip and palate[J]. Clin Oral Investig, 2016,20(1):23-30.
[16] Becker DB, Coalson RS, Sachanandani NS , et al. Functional neuroanatomy of lexical processing in children with cleft lip and palate[J]. Plast Reconstr Surg, 2008,122(5):1371-1382.
[17] Shinagawa H, Ono T, Honda E , et al. Distinctive cortical articulatory representation in cleft lip and palate: a preliminary functional magnetic resonance imaging study[J]. Cleft Palate Craniofac J, 2006,43(5):620-624.
[18] Zhang W, Li C, Chen L , et al. Increased activation of the hippocampus during a Chinese character subvocalization task in adults with cleft lip and palate palatoplasty and speech therapy[J]. Neuroreport, 2017,28(12):739-744.
[19] Goldsberry G , O’Leary D, Hichwa R, et al. Functional abnormalities in the neural circuitry of reading in men with nonsyndromic clefts of the lip or palate[J]. Cleft Palate Craniofac J, 2006,43(6):683-690.
[1] 夏溦瑶,贾仲林. 维生素与唇腭裂发生相关性的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 632-638.
[2] 杨冬叶,朱萍,吴淑仪. 舌位的影响因素及临床意义[J]. 国际口腔医学杂志, 2023, 50(6): 723-728.
[3] 刘云通,刘畅,高丽钞,罗瑜雪,曹钰彬,华成舸. 术后下牙槽神经功能障碍的研究进展[J]. 国际口腔医学杂志, 2023, 50(4): 479-484.
[4] 万雪丽,石永乐,张秀芬,王欢,田莉. 唇腭裂患儿全身麻醉苏醒期躁动多维干预体系的构建研究[J]. 国际口腔医学杂志, 2023, 50(3): 272-278.
[5] 陈卓,石冰,李精韬. 唇腭裂患者外鼻生长特征的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 279-286.
[6] 徐彦雪,付丽. 功能等级引导骨再生膜的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 353-358.
[7] 裴玲,曾妮,杨超,何苗,罗强,石冰,郑谦. 辅助局部麻醉对唇腭裂整复术后镇痛效果的研究[J]. 国际口腔医学杂志, 2022, 49(6): 657-662.
[8] 黄艺璇,石冰,李精韬. 唇腭裂患者鼻通气功能的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 453-461.
[9] 赵喆,王富,郑秀丽,安娜,陈吉华. 功能载荷下牙移动测量方法的研究进展[J]. 国际口腔医学杂志, 2022, 49(3): 362-366.
[10] 张琦,范存晖,杨茜,李然,徐晓琳,丁玮,王文惠,杨彩秀. 替牙期骨性Ⅲ类单侧完全性唇腭裂与非唇腭裂患者牙弓形态的对比研究[J]. 国际口腔医学杂志, 2022, 49(2): 144-152.
[11] 孙嘉琳,林岩松,石冰,贾仲林. 5种常见综合征型唇腭裂遗传学研究进展[J]. 国际口腔医学杂志, 2021, 48(6): 718-724.
[12] 马晓芳,黄永清,石冰,马坚. 双生子模型在唇腭裂病因学研究中的应用[J]. 国际口腔医学杂志, 2021, 48(5): 512-519.
[13] 朱轩智,赵蕾. 甲状腺功能减退症与牙周炎相关性的研究进展[J]. 国际口腔医学杂志, 2021, 48(4): 380-384.
[14] 赵文俊,陈宇. 引导组织/骨再生牙周功能梯度膜的研究进展[J]. 国际口腔医学杂志, 2021, 48(4): 391-397.
[15] 吴敏,石冰. 唇腭裂婴儿母乳喂养的研究进展[J]. 国际口腔医学杂志, 2021, 48(3): 269-273.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .