国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (4): 459-464.doi: 10.7518/gjkq.2018.04.016

• 综述 • 上一篇    下一篇

硅酸钙类盖髓剂生物学性能的研究进展

陈燕活, 安少锋, 高燕   

  1. 中山大学光华口腔医学院•附属口腔医院牙体牙髓病科 广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2017-10-14 修回日期:2018-04-08 出版日期:2018-07-02 发布日期:2018-07-02
  • 通讯作者: 高燕,副主任医师,硕士,Email：gaoyankq@aliyun.com
  • 作者简介:陈燕活,住院医师,硕士,Email：chyhuo23@163.com
  • 基金资助:
    中山大学青年教师培育项目（16ykpy01）

Research progress on the biological properties of calcium silicate-based pulp capping agents

Chen Yanhuo, An Shaofeng, Gao Yan   

  1. Dept. of Conservative Dentistry and Endodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University;Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2017-10-14 Revised:2018-04-08 Online:2018-07-02 Published:2018-07-02
  • Supported by:
    This study was supported by Training Program Foundation for the Youth Scholars of Sun Yat-sen University (16ykpy01).

RichHTML

17

PDF (PC)

634

摘要： 随着牙髓生物学和生物材料学研究的进步,微创诊疗理念的普及,活髓保存治疗已成为牙髓病学的研究热点之一。盖髓剂的生物学性能是决定活髓保存治疗效果的关键因素,硅酸钙类水门汀是一类具有良好的理化性能和生物相容性的新型盖髓剂,能诱导牙髓组织中具有分化潜能的细胞分化为成牙本质样细胞,促进修复性牙本质的形成,已广泛应用于活髓保存治疗,取得了良好的治疗效果。但其种类相对较多,且有大量相关基础和临床应用研究报道,因此本文将对目前常用的硅酸钙类盖髓剂的生物学性能进行综述,以期为临床合理应用提供参考。

关键词: 硅酸钙, 盖髓剂, 牙髓细胞, 成牙本质向分化

Abstract: With the progress of the dental pulp biology and biomaterials research, minimally invasive clinical approach including vital pulp therapy has become a hot spot in endodontics. Biological properties of pulp capping agent play a pivotal role in determining the events of vital pulp therapy. Calcium silicate cements are biocompatible novel materials with excellent physicochemical properties and capacity for stimulating reparative dentin formation. Currently, different types of calcium silicate cements have been applied to vital pulp therapy and achieved good clinical outcomes. However, there is a great quantity of researches regarding these materials, which may confuse readers. Therefore, the aim of this paper is to review current progress on biological properties and feasible strategies of different calcium silicate-based capping agents in order to provide a reference for their rational clinical application.

Key words: calcium silicate, pulp capping, dental pulp cells, odontoblastic differentiation

中图分类号: 

  • R781.05
[1] Ranly DM, Garcia-Godoy F.Current and potential pulp therapies for primary and young permanent teeth[J]. J Dent, 2000, 28(3): 153-161.
[2] Jitaru S, Hodisan I, Timis L, et al.The use of bio-ceramics in endodontics-literature review[J]. Clujul Med, 2016, 89(4): 470-473.
[3] Sonmez D,Duruturk L.Success rate of calcium hyd-roxide pulpotomy in primary molars restored with amalgam and stainless steel crowns[J].Br Dent J, 2010,208(9): E18, discussion 408-409.
[4] Camilleri J.Characterization of hydration products of mineral trioxide aggregate[J]. Int Endod J, 2008, 41(5): 408-417.
[5] Oliveira MG, Xavier CB, Demarco FF, et al.Com-parative chemical study of MTA and Portland cements[J]. Braz Dent J, 2007, 18(1): 3-7.
[6] Okiji T, Yoshiba K.Reparative dentinogenesis in-duced by mineral trioxide aggregate: a review from the biological and physicochemical points of view[J]. Int J Dent, 2009, 2009: 464280.
[7] Gandolfi MG, Shah SN, Feng R, et al.Biomimetic calcium-silicate cements support differentiation of human orofacial mesenchymal stem cells[J]. J Endod, 2011, 37(8): 1102-1108.
[8] Belobrov I, Parashos P.Treatment of tooth discolo-ration after the use of white mineral trioxide aggre-gate[J]. J Endod, 2011, 37(7): 1017-1020.
[9] Zhu L, Yang J, Zhang J, et al.A comparative study of BioAggregate and ProRoot MTA on adhesion, migration, and attachment of human dental pulp cells[J]. J Endod, 2014, 40(8): 1118-1123.
[10] Leal F, De-Deus G, Brandão C, et al.Similar sealabi-lity between bioceramic putty ready-to-use repair cement and white MTA[J]. Braz Dent J, 2013, 24(4): 362-366.
[11] Ramos JC, Palma PJ, Nascimento R, et al.1-year in vitro evaluation of tooth discoloration induced by 2 calcium silicate-based cements[J]. J Endod, 2016, 42(9): 1403-1407.
[12] Shokouhinejad N, Nekoofar MH, Pirmoazen S, et al.Evaluation and comparison of occurrence of tooth discoloration after the application of various calcium silicate-based cements: an ex vivo study[J]. J Endod, 2016, 42(1): 140-144.
[13] Schembri M, Peplow G, Camilleri J.Analyses of heavy metals in mineral trioxide aggregate and Por-tland cement[J]. J Endod, 2010, 36(7): 1210-1215.
[14] Briso AL, Rahal V, Mestrener SR, et al.Biological response of pulps submitted to different capping materials[J]. Braz Oral Res, 2006, 20(3): 219-225.
[15] Tian J, Zhang Y, Lai Z, et al.Ion release, micros-tructural, and biological properties of iRoot BP Plus and ProRoot MTA exposed to an acidic environment[J]. J Endod, 2017, 43(1): 163-168.
[16] Zhang S, Yang X, Fan M.BioAggregate and iRoot BP Plus optimize the proliferation and mineralization ability of human dental pulp cells[J]. Int Endod J, 2013, 46(10): 923-929.
[17] Liu S, Wang S, Dong Y.Evaluation of a bioceramic as a pulp capping agent in vitro and in vivo[J]. J Endod, 2015, 41(5): 652-657.
[18] Agrafioti A, Taraslia V, Chrepa V, et al.Interaction of dental pulp stem cells with Biodentine and MTA after exposure to different environments[J]. J Appl Oral Sci, 2016, 24(5): 481-486.
[19] Poggio C, Ceci M, Beltrami R, et al.Biocompatibi-lity of a new pulp capping cement[J]. Ann Stomatol (Roma), 2014, 5(2): 69-76.
[20] De-Deus G, Canabarro A, Alves GG, et al.Cytocom-patibility of the ready-to-use bioceramic putty repair cement iRoot BP Plus with primary human osteo-blasts[J]. Int Endod J, 2012, 45(6): 508-513.
[21] Zhu L, Yang J, Zhang J, et al. In vitro and in vivo evaluation of a nanoparticulate bioceramic paste for dental pulp repair[J]. Acta Biomater, 2014, 10(12): 5156-5168.
[22] Park SJ, Heo SM, Hong SO, et al.Odontogenic ef-fect of a fast-setting pozzolan-based pulp capping material[J]. J Endod, 2014, 40(8): 1124-1131.
[23] D’Souza RN, Bachman T, Baumgardner KR, et al. Characterization of cellular responses involved in reparative dentinogenesis in rat molars[J]. J Dent Res, 1995, 74(2): 702-709.
[24] Lu Y, Ye L, Yu S, et al.Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo[J]. Dev Biol, 2007, 303(1): 191-201.
[25] Saito K, Nakatomi M, Ida-Yonemochi H, et al.Os-teopontin is essential for type Ⅰ collagen secretion in reparative dentin[J]. J Dent Res, 2016, 95(9): 1034-1041.
[26] Chang SW, Lee SY, Kum KY, et al.Effects of Pro-Root MTA, Bioaggregate, and Micromega MTA on odontoblastic differentiation in human dental pulp cells[J]. J Endod, 2014, 40(1): 113-118.
[27] Chang SW, Lee SY, Ann HJ, et al.Effects of calcium silicate endodontic cements on biocompatibility and mineralization-inducing potentials in human dental pulp cells[J]. J Endod, 2014, 40(8): 1194-1200.
[28] 乔迪, 董艳梅, 高学军. 体外评价新型根尖倒充填材料iRoot的生物学性能[J]. 北京大学学报(医学版), 2016, 48(2): 324-329.Qiao D, Dong YM, Gao XJ.In vitro study of biolo-gical characteristics of new retrograde filling ma-terials iRoot[J]. J Peking Univ (Health Sci), 2016, 48(2): 324-329.
[29] Lee BN, Lee KN, Koh JT, et al.Effects of 3 endo-dontic bioactive cements on osteogenic differentia-tion in mesenchymal stem cells[J]. J Endod, 2014, 40(8): 1217-1222.
[30] Azimi S, Fazlyab M, Sadri D, et al.Comparison of pulp response to mineral trioxide aggregate and a bioceramic paste in partial pulpotomy of sound human premolars: a randomized controlled trial[J]. Int Endod J, 2014, 47(9): 873-881.
[31] Nowicka A, Lipski M, Parafiniuk M, et al.Response of human dental pulp capped with biodentine and mineral trioxide aggregate[J]. J Endod, 2013, 39(6): 743-747.
[32] Shi S, Bao ZF, Liu Y, et al.Comparison of in vivo dental pulp responses to capping with iRoot BP Plus and mineral trioxide aggregate[J]. Int Endod J, 2016, 49(2): 154-160.
[33] Tziafa C, Koliniotou-Koumpia E, Papadimitriou S, et al.Dentinogenic responses after direct pulp cap-ping of miniature swine teeth with Biodentine[J]. J Endod, 2014, 40(12): 1967-1971.
[34] Kim J, Song YS, Min KS, et al.Evaluation of repara-tive dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohis-tochemistry[J]. Restor Dent Endod, 2016, 41(1): 29-36.
[35] Zhao X, He W, Song Z, et al.Mineral trioxide ag-gregate promotes odontoblastic differentiation via mitogen-activated protein kinase pathway in human dental pulp stem cells[J]. Mol Biol Rep, 2012, 39(1): 215-220.
[36] Tang Y, Vater C, Jacobi A, et al.Salidroside exerts angiogenic and cytoprotective effects on human bone marrow-derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways[J]. Br J Pharmacol, 2014, 171(9): 2440-2456.
[37] Jung JY, Woo SM, Lee BN, et al.Effect of Bio-dentine and Bioaggregate on odontoblastic differen-tiation via mitogen-activated protein kinase pathway in human dental pulp cells[J]. Int Endod J, 2015, 48(2): 177-184.
[38] Plotnikov SV, Waterman CM.Guiding cell migra-tion by tugging[J]. Curr Opin Cell Biol, 2013, 25(5): 619-626.
[39] Zhang J, Zhu LX, Cheng X, et al.Promotion of dental pulp cell migration and pulp repair by a bio-ceramic putty involving FGFR-mediated signaling pathways[J]. J Dent Res, 2015, 94(6): 853-862.
[40] Cuadros-Fernández C, Lorente Rodríguez AI, Sáez-Martínez S, et al.Short-term treatment outcome of pulpotomies in primary molars using mineral trioxide aggregate and Biodentine: a randomized clinical trial[J]. Clin Oral Investig, 2016, 20(7): 1639-1645.
[41] Çelik BN, Sarı Ş.Carious exposure versus me-chanical exposure for MTA pulpotomy in primary teeth[J]. Biomed Res Int, 2016, 2016: 2753429.
[42] Soni HK. Biodentine pulpotomy in mature permanent molar: a case report[J]. J Clin Diagn Res, 2016,10 (7): ZD09-ZD11.
[43] Linsuwanont P, Wimonsutthikul K, Pothimoke U, et al.Treatment outcomes of mineral trioxide aggregate pulpotomy in vital permanent teeth with carious pulp exposure: the retrospective study[J]. J Endod, 2017, 43(2): 225-230.
[44] Abarajithan M, Velmurugan N, Kandaswamy D.Management of recently traumatized maxillary central incisors by partial pulpotomy using MTA: case reports with two-year follow-up[J]. J Conserv Dent, 2010, 13(2): 110-113.
[45] Hashem D, Mannocci F, Patel S, et al.Clinical and radiographic assessment of the efficacy of calcium silicate indirect pulp capping: a randomized controlled clinical trial[J]. J Dent Res, 2015, 94(4): 562-568.
[46] Yoldaş SE, Bani M, Atabek D, et al.Comparison of the potential discoloration effect of Bioaggregate, Biodentine, and White Mineral Trioxide Aggregate on bovine teeth: in vitro research[J]. J Endod, 2016, 42(12): 1815-1818.
[47] Kaup M, Schäfer E, Dammaschke T.An in vitro study of different material properties of Biodentine compared to ProRoot MTA[J]. Head Face Med, 2015, 11: 16.
[1] 张曦丹,孙吉宇,付馨靓,甘雪琦. 介孔硅酸钙纳米材料在牙体牙髓及颅颌面修复领域的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 476-482.
[2] 张凯莹,房付春,吴补领. 非编码RNA在牙源性干细胞成牙本质向分化中作用的研究进展[J]. 国际口腔医学杂志, 2019, 46(5): 540-545.
[3] 房宏志, 杨惠, 邵美瑛, 胡涛. 溶血磷脂酸对牙髓细胞中β-连环蛋白核转位的影响及机制初探[J]. 国际口腔医学杂志, 2018, 45(1): 26-31.
[4] 李蕾, 乔祥晨 崔彩云, 郭维华, 田卫东, . 光引发聚合改性明胶用于牙组织工程的可能性初探[J]. 国际口腔医学杂志, 2015, 42(3): 265-268.
[5] 龚启梅综述 凌均棨审校. 基因芯片技术在牙髓生物学研究中的应用进展[J]. 国际口腔医学杂志, 2012, 39(5): 608-611.
[6] 苟文亭综述 叶玲 谭红审校. 牙髓干细胞分化的研究进展[J]. 国际口腔医学杂志, 2012, 39(3): 380-383.
[7] 杨惠综述 胡涛审校. 牙髓细胞迁移的研究进展[J]. 国际口腔医学杂志, 2009, 36(3): 294-296.
[8] 孙海,谭红,叶玲. 体外培养牙髓细胞分化相关标记物的研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): -.
[9] 朱玉婷, 杨惠综述 胡涛审校. 牙髓程序性细胞死亡的研究进展[J]. 国际口腔医学杂志, 2008, 35(2): 147-150.
[10] 张琛,侯本祥,. 生物活性盖髓剂发展现状[J]. 国际口腔医学杂志, 2006, 33(03): 201-203.
[11] 张帼,黄翠. 牙体粘接树脂的生物相容性及其影响因素[J]. 国际口腔医学杂志, 2005, 32(02): 157-158.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .