国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (2): 224-227.doi: 10.7518/gjkq.2018.02.018

• 综述 • 上一篇    下一篇

疱疹病毒与牙周炎的关系

郑直, 颜世果   

  1. 山东大学口腔医院牙周科
    山东省口腔组织再生重点实验室 济南 250012
  • 收稿日期:2017-07-20 修回日期:2017-11-09 出版日期:2018-03-01 发布日期:2018-03-01
  • 通讯作者: 颜世果,副主任医师,博士,Email:syan@sdu.edu.cn
  • 作者简介:郑直,硕士,Email:280095420@qq.com
  • 基金资助:
    国家自然科学基金青年科学基金(81200790);山东省重点研发计划(公益类专项)项目(2017GSF218063);山东省自然科学基金青年项目(ZR2012HQ028)

Relationship between herpes virus and periodontitis

Zheng Zhi, Yan Shiguo   

  1. Dept. of Periodontology, Hospital of Stomatology, Shandong University
    Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
  • Received:2017-07-20 Revised:2017-11-09 Online:2018-03-01 Published:2018-03-01
  • Supported by:
    This study was supported by Young Scientists Fund of the National Natural Science Foundation of China (81200790), Key Research and Development Plan (Public Welfare Category) of Shandong (2017GSF218063) and Young Scientists Fund of the Natural Science Foundation of Shangdong (ZR2012HQ028).

摘要: 疱疹病毒是自然界中常见的病毒,与牙周炎之间关系的研究备受关注,其普遍存在于慢性牙周炎、侵袭性牙周炎患者的口腔之中,这类病毒通过对细胞的直接损伤作用,干扰宿主的免疫反应以及与牙周致病菌之间建立协同关系,在牙周炎的致病中扮演一定角色。因此,本文将疱疹病毒与牙周炎的研究现状进行综述。

关键词: 牙周炎, 疱疹病毒, 致病机制

Abstract: Herpes virus is common in nature and closely related to periodontitis. Herpes virus is widespread in the oral cavity of patients with chronic periodontitis, aggressive periodontitis. Herpes virus plays a role in periodontitis by direct damage to cells, interfere with host immune system, and establishing a co-relationship with periodontal pathogens. Hereby, the researches between herpes virus and periodontitis were reviewed.

Key words: periodontitis, herpes virus, pathogenesis

中图分类号: 

  • R781.4
[1] Bilder L, Elimelech R, Szwarcwort-Cohen M, et al.The prevalence of human herpes viruses in the saliva of chronic periodontitis patients compared to oral health providers and healthy controls[J]. Arch Virol, 2013, 158(6):1221-1226.
[2] Chalabi M, Rezaie F, Moghim S, et al.Periodontopa-thic bacteria and herpesviruses in chronic periodontitis[J]. Mol Oral Microbiol, 2010, 25(3):236-240.
[3] Sahin S, Saygun I, Kubar A, et al.Periodontitis lesions are the main source of salivary cytomegalo-virus[J]. Oral Microbiol Immunol, 2009, 24(4):340-342.
[4] Muzammil, Jayanthi D, Faizuddin M, et al. Associa-tion of interferon lambda-1 with herpes simplex vi-ruses-1 and -2, Epstein-Barr virus, and human cyto-megalovirus in chronic periodontitis[J]. J Investig Clin Dent, 2017, 8(2). doi: 10.1111/jicd.12200.
[5] Sharma R, Padmalatha O, Kaarthikeyan G, et al.Comparative analysis of presence of Cytomegalo-virus (CMV) and Epsteinbarr virus -1 (EBV-1) in cases of chronic periodontitis and aggressive perio-dontitis with controls[J]. Indian J Dent Res, 2012, 23(4):454-458.
[6] Kubar A, Saygun I, Ozdemir A, et al.Real-time polymerase chain reaction quantification of human cytomegalovirus and Epstein-Barr virus in periodon-tal pockets and the adjacent gingiva of periodontitis lesions[J]. J Periodontal Res, 2005, 40(2):97-104.
[7] Ling PD, Lednicky JA, Keitel WA, et al.The dynamics of herpesvirus and polyomavirus reactivation and shedding in healthy adults: a 14-month longitudinal study[J]. J Infect Dis, 2003, 187(10):1571-1580.
[8] Dawson DR, Wang C, Danaher RJ, et al.Real-time polymerase chain reaction to determine the prevalence and copy number of epstein-barr virus and cytome-galovirus DNA in subgingival plaque at individual healthy and periodontal disease sites[J]. J Perio-dontol, 2009, 80(7):1133-1140.
[9] Kato A, Imai K, Ochiai K, et al.Higher prevalence of Epstein-Barr virus DNA in deeper periodontal pockets of chronic periodontitis in Japanese patients[J]. PLoS One, 2013, 8(8):e71990.
[10] Bertoldi C, Pellacani C, Lalla M, et al.Herpes Sim-plex Ⅰ virus impairs regenerative outcomes of perio-dontal regenerative therapy in intrabony defects: a pilot study[J]. J Clin Periodontol, 2012, 39(4):385-392.
[11] Petrović SM, Zelić K, Milasin J, et al.Detection of herpes simplex virus type 1 in gingival crevicular fluid of gingival sulcus/periodontal pocket using polymerase chain reaction[J]. Srp Arh Celok Lek, 2014, 142(5/6):296-300.
[12] Yapar M, Saygun I, Ozdemir A, et al.Prevalence of human herpesviruses in patients with aggressive periodontitis[J]. J Periodontol, 2003, 74(11):1634-1640.
[13] Saygun I, Kubar A, Ozdemir A, et al.Herpesviral-bacterial interrelationships in aggressive periodonti-tis[J]. J Periodontal Res, 2004, 39(4):207-212.
[14] Ling LJ, Ho CC, Wu CY, et al.Association between human herpesviruses and the severity of periodontitis[J]. J Periodontol, 2004, 75(11):1479-1485.
[15] Bilichodmath S, Mangalekar SB, Sharma DC, et al.Herpesviruses in chronic and aggressive periodontitis patients in an Indian population[J]. J Oral Sci, 2009, 51(1):79-86.
[16] Rodrigues PM, Teixeira AL, Kustner EC, et al.Are herpes virus associated to aggressive periodontitis? A review of literature[J]. J Oral Maxillofac Pathol, 2015, 19(3):348-355.
[17] Sharma S, Tapashetti RP, Patil SR, et al.Revelation of viral-bacterial interrelationship in aggressive perio-dontitis via polymerase chain reaction: a microbiolo-gical study[J]. J Int Oral Health, 2015, 7(9):101-107.
[18] Slots J.Herpesviral-bacterial interactions in perio-dontal diseases[J]. Periodontol 2000, 2010, 52(1): 117-140.
[19] Betts K, Abusleme L, Freeman AF, et al.A 17-year old patient with DOCK8 deficiency, severe oral HSV-1 and aggressive periodontitis-a case of virally induced periodontitis[J]. J Clin Virol, 2015, 63:46-50.
[20] Verdugo F, Castillo A, Castillo F, et al.Epstein-Barr virus associated peri-implantitis: a split-mouth study[J]. Clin Oral Investig, 2015, 19(2):535-543.
[21] Contreras A, Zadeh HH, Nowzari H, et al.Herpe-svirus infection of inflammatory cells in human pe-riodontitis[J]. Oral Microbiol Immunol, 1999, 14(4): 206-212.
[22] Savard M, Gosselin J.Epstein-Barr virus immunos-suppression of innate immunity mediated by phagocytes[J]. Virus Res, 2006, 119(2):134-145.
[23] Ressing ME, Horst D, Griffin BD, et al.Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products[J]. Semin Cancer Biol, 2008, 18(6):397-408.
[24] Slots J, Saygun I, Sabeti M, et al.Epstein-Barr virus in oral diseases[J]. J Periodontal Res, 2006, 41(4): 235-244.
[25] Lin YL, Li M.Human cytomegalovirus and Epstein-Barr virus inhibit oral bacteria-induced macrophage activation and phagocytosis[J]. Oral Microbiol Im-munol, 2009, 24(3):243-248.
[26] Baqui AA, Jabra-Rizk MA, Kelley JI, et al.Enhanced interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha production by LPS stimulated human monocytes isolated from HIV+ patients[J]. Immuno-pharmacol Immunotoxicol, 2000, 22(3):401-421.
[27] Slots J.Herpesviruses in periodontal diseases[J]. Periodontol 2000, 2005, 38:33-62.
[28] Verdugo F, Castillo A, Simonian K, et al.Periodonto-pathogen and Epstein-Barr virus contamination affects transplanted bone volume in sinus augmentation[J]. J Periodontol, 2012, 83(2):162-173.
[29] Sugano N, Ikeda K, Oshikawa M, et al.Relationship between Porphyromonas gingivalis, Epstein-Barr virus infection and reactivation in periodontitis[J]. J Oral Sci, 2004, 46(4):203-206.
[1] 傅豫, 何薇, 黄兰. 铁死亡在口腔疾病中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 36-44.
[2] 罗晓洁,王德续,陈晓涛. 基于生物信息学分析铁死亡调控基因与牙周炎的关系[J]. 国际口腔医学杂志, 2023, 50(6): 661-668.
[3] 黄元鸿,彭显,周学东. 骨碎补在治疗口腔骨相关疾病的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 679-685.
[4] 龚美灵,程兴群,吴红崑. 牙周炎与帕金森病相关性的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 587-593.
[5] 孙佳,韩烨,侯建霞. 白细胞介素-6-铁调素信号轴调控牙周炎相关性贫血致病机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 329-334.
[6] 刘体倩,梁星,刘蔚晴,李晓虹,朱睿. 咬合创伤在牙周炎发生发展中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 19-24.
[7] 李琼,于维先. 白藜芦醇治疗牙周炎及其生物利用度的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 25-31.
[8] 黄伟琨,徐秋艳,周婷. 黄芩苷抑制脂多糖促巨噬细胞氧化应激损伤作用的研究[J]. 国际口腔医学杂志, 2022, 49(5): 521-528.
[9] 周剑鹏,谢旭东,赵蕾,王骏. 辅助性T细胞17及白细胞介素17在牙周炎中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 586-592.
[10] 陈荟宇,白明茹,叶玲. 信号素3A与口腔常见病关系的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 593-599.
[11] 王冠儒,冯强. 牙龈卟啉单胞菌在阿尔兹海默症发生中作用的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 397-403.
[12] 周佳佳,赵蕾,徐欣. 牙周炎相关基因多态性的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 432-440.
[13] 马玉,左玉,张鑫. 光动力疗法辅助治疗牙周炎治疗效果的Meta分析[J]. 国际口腔医学杂志, 2022, 49(3): 305-316.
[14] 钱素婷,丁玲敏,纪雅宁,林军. 微小RNA在牙周炎龈沟液中的表达差异及对牙周炎的调控机制[J]. 国际口腔医学杂志, 2022, 49(3): 349-355.
[15] 蒋端,申道南,赵蕾,吴亚菲. 内皮发育调节基因-1与牙周炎相关性的研究进展[J]. 国际口腔医学杂志, 2022, 49(2): 244-248.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 王昆润. 二甲亚砜和双氯芬酸并用治疗根尖周炎[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 汤庆奋,王学侠. 17β-雌二醇对人类阴道和口腔颊粘膜的渗透性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 杨锦波. 嵌合体防龋疫苗的研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 王昆润. 下颔骨成形术用网状钛板固定植骨块[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 汪月月,郭莉莉. 口腔机能与老化—痴呆危险因素流行病学研究[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 丁刚. 应用硬组织代用品种植体行丰颏术[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 田磊. 局部应用脂多糖后结合上皮反应性增生的变化[J]. 国际口腔医学杂志, 1999, 26(04): .
[10] 戴青. 口腔念珠菌病的新分类[J]. 国际口腔医学杂志, 1999, 26(04): .