CD24在口腔医学中的研究进展

doi:10.7518/gjkq.2017.05.023

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (5): 608-613.doi: 10.7518/gjkq.2017.05.023

CD24在口腔医学中的研究进展

梁静¹, 王凯¹, 吴家媛^{1, 2}

1.遵义医学院口腔学院遵义 563099;
2.贵州省高等学校口腔疾病研究特色重点实验室遵义 563099

收稿日期:2016-12-19 修回日期:2017-05-15 出版日期:2017-09-01 发布日期:2017-09-01
通讯作者: 吴家媛,副教授,博士,Email：wujiayuan@zmc.edu.cn
作者简介:梁静,住院医师,硕士,Email：845892497@qq.com
基金资助:
国家自然科学基金（81460102）; 贵州省省长基金（[2012]- 16）; 贵州省遵义市红花岗基金（[2012]07）; 贵州省科技创新人才团队资助（[2013]4026）; 贵州省高等学校特色重点实验室建设项目（[2013]109）

Research progress on CD24 in stomatology

Liang Jing¹, Wang Kai¹, Wu Jiayuan^{1, 2}

1. School of Stomatology, Zunyi Medical University, Zunyi 563099, China;
2. Special Key Laboratory of Oral Diseases Research, Institutions of Higher Learning in Guizhou Province, Zunyi 563099, China

Received:2016-12-19 Revised:2017-05-15 Online:2017-09-01 Published:2017-09-01
Supported by:
; This study was supported by National Natural Science Foundation of China(81460102), Governor Foundation of Guizhou Province([2012]16), Zunyi Honghuagang Science Foundation of Guizhou Province([2012]07), Science Innovative Team Foundation of Guizhou Province([2013]4026) and Special Laboratory Construction Foundation of Higher Education of Guizhou Province([2013]109).

摘要/Abstract

摘要： CD24分子是细胞表面的一种糖蛋白,可表达于多种细胞,如前体B细胞、T细胞、神经细胞、肌细胞及肿瘤细胞等。近年来,科学家们针对CD24在医学研究中的重要表现做了大量研究,发现在炎症、肿瘤及干细胞等领域中均有CD24的参与。尽管CD24的功能尚不清楚,但有研究提示它参与了部分口腔疾病的发生和发展。故此文针对CD24在口腔医学领域的相关研究作一总结,以促进该领域研究的进一步发展。

关键词: CD24, 口腔医学, 牙周病, 自身免疫性疾病, 口腔肿瘤

Abstract: CD24 is a cell surface glycoprotein expressed in pre-B cells, T cells, neurons, muscle cells, and carcinoma cells. Many researchers reported that CD24 plays an important role in inflammation, autoimmune diseases, and cancer. The function of this protein remains unclear. However, CD24 may be involved in various oral diseases. Hence, this study summarizes major findings associated with CD24 to stimulate new ideas that can be used for further research and reveal underlying links among diverse processes mediated by CD24.

Key words: CD24, stomatology, periodontal disease, autoimmune disease, oral tumor

中图分类号:

梁静, 王凯, 吴家媛. CD24在口腔医学中的研究进展[J]. 国际口腔医学杂志, 2017, 44(5): 608-613.

Liang Jing, Wang Kai, Wu Jiayuan. Research progress on CD24 in stomatology[J]. Inter J Stomatol, 2017, 44(5): 608-613.

参考文献

[1] Buck K, Hug S, Seibold P, et al. CD24 polymorphisms in breast cancer: impact on prognosis and risk[J]. Breast Cancer Res Treat, 2013, 137(3):927-937.
[2] Sonoyama W, Liu Y, Fang D, et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine[J]. PLoS One, 2006, 1:e79.
[3] Hough MR, Rosten PM, Sexton TL, et al. Mapping of CD24 and homologous sequences to multiple chromosomal loci[J]. Genomics, 1994, 22(1):154- 161.
[4] Zhou Q, Guo Y, Liu Y. Regulation of the stability of heat-stable antigen mRNA by interplay between two novel cis elements in the 3’ untranslated region[J]. Mol Cell Biol, 1998, 18(2):815-826.
[5] Wenger RH, Ayane M, Bose R, et al. The genes for a mouse hematopoietic differentiation maker called the heat-stable antigen[J]. Eur J Immunol, 1991, 21 (4):1039-1046.
[6] Sagiv E, Arber N. The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy[J]. Expert Rev Gastroen-terol Hepatol, 2008, 2(1):125-133.
[7] Bui FQ, Johnson L, Roberts J, et al. Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1β and the danger signals ASC and HMGB1[J]. Cell Microbiol, 2016, 18(7):970-981.
[8] Tsuda H, Ning Z, Yamaguchi Y, et al. Programmed cell death and its possible relationship with perio-dontal disease[J]. J Oral Sci, 2012, 54(2):137-149.
[9] Sirisinha S. Insight into the mechanisms regulating immune homeostasis in health and disease[J]. Asian Pac J Allergy Immunol, 2011, 29(1):1-14.
[10] Li DX, Deng TZ, Lv J, et al. Advanced glycation end products(AGEs) and their receptor(RAGE) induce apoptosis of periodontal ligament fibroblasts [J]. Braz J Med Biol Res, 2014, 47(12):1036-1043.
[11] Chen GY, Tang J, Zheng P, et al. CD24 and Siglec- 10 selectively repress tissue damage-induced immune responses[J]. Science, 2009, 323(5922):1722-1725.
[12] Ye P, Chapple CC, Kumar RK, et al. Expression pat-terns of E-cadherin, involucrin and connexin gap junc-tion proteins in the lining epithelia of inflamed gin-giva[J]. J Pathol, 2000, 192(1):58-66.
[13] Ye P, Simonian M, Nadkarni MA, et al. Identifica-tion of epithelial auto-antigens associated with perio-dontal disease[J]. Clin Exp Immunol, 2005, 139(2): 328-337.
[14] Ye P, Nadkarni MA, Hunter N. Regulation of E- cadherin and TGF-β3 expression by CD24 in cul-tured oral epithelial cells[J]. Biochem Biophys Res Commun, 2006, 349(1):229-235.
[15] Ye P, Yu H, Simonian M, et al. Ligation of CD24 expressed by oral epithelial cells induces kinase dependent decrease in paracellular permeability mediated by tight junction proteins[J]. Biochem Biophys Res Commun, 2011, 412(1):165-169.
[16] Abe-Yutori M, Chikazawa T, Shibasaki K, et al. Decreased expression of E-cadherin by Porphyromonas gingivalis -lipopolysaccharide attenuates epithelial barrier function[J]. J Periodontal Res, 2017, 52(1): 42-50.
[17] Ye P, Nadkarni MA, Simonian M, et al. CD24 regulated gene expression and distribution of tight junction proteins is associated with altered barrier function in oral epithelial monolayers[J]. BMC Cell Biol, 2009, 10:2.
[18] Ye P, Yu H, Simomian M, et al. Expression patterns of tight junction components induced by CD24 in an oral epithelial cell-culture model correlated to af-fected periodontal tissues[J]. J Periodontal Res, 2014, 49(2):253-259.
[19] Guo W, Ye P, Yu H, et al. CD24 activates the NL-RP3 inflammasome through c-Src kinase activity in a model of the lining epithelium of inflamed perio-dontal tissues[J]. Immun Inflamm Dis, 2014, 2(4): 239-253.
[20] 朱家友, 王继华. 口腔黏膜皮肤病学[M]. 武汉: 湖北科学技术出版社, 2003.
Zhu JY, Wang JH. Oral mucosal dermatology[M]. Wuhan: Hubei Science and Technology Press, 2003.
[21] Tan Y, Zhao M, Xiang B, et al. CD24: from a hematopoietic differentiation antigen to a genetic risk factor for multiple autoimmune diseases[J]. Clin Rev Allergy Immunol, 2016, 50(1):70-83.
[22] 王芳, 刘健, 叶英法, 等. 干燥综合征患者心肺功能的变化与CD19+CD24+Brge及BTLA的相关性分析[J]. 风湿病与关节炎, 2014, 3(2):5-10.
Wang F, Liu J, Ye YF, et al. Changes of heart and lung function in patients with Sjögren syndrome and their correlativity with CD19+CD24+Brge and BTLA [J]. Rheum Arthritis, 2014, 3(2):5-10.
[23] Thaxton JE, Liu B, Zheng P, et al. Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells[J]. J Immunol, 2014, 192(12):5679-5686.
[24] Wang L, Lin S, Rammohan KW, et al. A dinucleotide deletion in CD24 confers protection against auto-immune diseases[J]. PLoS Genet, 2007, 3(4):e49.
[25] Zhou Q, Rammohan K, Lin S, et al. CD24 is a genetic modifier for risk and progression of multiple sclerosis [J]. Proc Natl Acad Sci USA, 2003, 100 (25):15041- 15046.
[26] Otaegui D, Sáenz A, Camaño P, et al. CD24 V/V is an allele associated with the risk of developing mul-tiple sclerosis in the Spanish population[J]. Mult Scler, 2006, 12(4):511-514.
[27] Huang J, Yang Y, Liang Z, et al. Association be-tween the CD24 Ala57Val polymorphism and risk for multiple sclerosis and systemic lupus erythema-tosus: a meta-analysis[J]. Sci Rep, 2015, 5:9557.
[28] Baek J, Kang S, Byeon H, et al. Contribution of CD24 polymorphisms to autoimmune disease: a meta-analysis[J]. Comput Biol Med, 2015, 64:268-275.
[29] Fang X, Zheng P, Tang J, et al. CD24: from A to Z[J]. Cell Mol Immunol, 2010, 7(2):100-103.
[30] Keeratichamroen S, Leelawat K, Thongtawee T, et al. Expression of CD24 in cholangiocarcinoma cells is associated with disease progression and reduced patient survival[J]. Int J Oncol, 2011, 39(4):873-881.
[31] Salaria S, Means A, Revetta F, et al. Expression of CD24, a stem cell marker, in pancreatic and small intestinal neuroendocrine tumors[J]. Am J Clin Pathol, 2015, 144(4):642-648.
[32] 庄建良, 苏子剑, 许荣誉. CD24与肿瘤侵袭的关系[J]. 国际病理科学与临床杂志, 2006, 26(5):387- 400.
Zhuang JL, Su ZJ, Xu RY. Role of CD24 in tumor progression and metastasis[J]. J Int Pathol Clin Med, 2006, 26(5):387-400.
[33] 王震, 齐鸿亮, 邢劲松. CD24、CD105在腺样囊性癌中的表达[J]. 中国药学与临床, 2012, 12(3):315- 316.
Wang Z, Qi HL, Xing JS. The expression of CD24 and CD105 in adenoid cystic carcinoma[J]. Chin Remed Clin, 2012, 12(3):315-316.
[34] Ghuwalewala S, Ghatak D, Das P, et al. CD44 high CD24 low molecular signature determines the cancer stem cell and EMT phenotype in oral squamous cell carcinoma[J]. Stem Cell Res, 2016, 16(2):405-417.
[35] Ianez RC, Coutinho-Camillo CM, Buim ME, et al. CD24 and CD44 in salivary gland pleomorphic adenoma and in human salivary gland morphognesis: differenial markers of glandular structure or stem cell indicators[J]. Histopathology, 2013, 62(7):1075- 1082.
[36] Abdulmajeed AA, Dalley AJ, Farah CS. Putative cancer stem cell marker expression in oral epithelial dysplasia and squamous cell carcinoma[J]. J Oral Pathol Med, 2013, 42(10):755-760.
[37] Zhang B, Lin T, He H. Comparative analysis of blood and saliva expression profiles in chronic and refractory periodontitis patients[J]. BMC Oral Health, 2015, 15:166.
[38] Kaplan I, Nabiochtchikov I, Leshno A, et al. Asso-ciation of CD24 and the adenomatous polyposis coli gene polymorphisms with oral lichen planus[J]. OralSurg Oral Med Oral Pathol Oral Radiol, 2015, 120 (3):378-385.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

CD24在口腔医学中的研究进展

Research progress on CD24 in stomatology

RichHTML

PDF (PC)

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

Metrics

本文评价

推荐阅读 10

[1]	古丽其合热·阿布来提,秦旭,朱光勋. 线粒体自噬在牙周炎发生发展过程中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 68-73.
[2]	谭永臻,梁新华. 口腔局部麻醉药抗菌机制的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 74-81.
[3]	戴清仪,郝昊,华成舸,黄波,杨征. 口腔及颅颌面部常见运动防护用具的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 366-373.
[4]	成益凡,秦旭,姜鸣,朱光勋. 牙周病中固有淋巴细胞的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 32-36.
[5]	李伟光,吴亚菲,郭淑娟. 无机纳米粒子在牙周病诊疗中的研究进展[J]. 国际口腔医学杂志, 2022, 49(6): 724-730.
[6]	李归平,秦旭,朱光勋. 腺苷酸活化蛋白激酶在牙周病发生发展中的研究进展[J]. 国际口腔医学杂志, 2022, 49(3): 343-348.
[7]	穆新月,刘树泰. 动机性访谈在牙周病患者临床管理中的应用进展[J]. 国际口腔医学杂志, 2022, 49(1): 94-99.
[8]	白皓亮,杨禾,赵蕾. 牙周病风险评估及预后判断工具的研究进展[J]. 国际口腔医学杂志, 2021, 48(6): 696-702.
[9]	周万航,李嫣斐,许日聪,万启军. 牙周非手术治疗对慢性肾脏病危险因素及全身炎症水平影响的Meta分析[J]. 国际口腔医学杂志, 2021, 48(5): 528-535.
[10]	沈忆芬,刘超,汤颖,顾永春. 电子烟暴露对牙周健康影响的研究进展[J]. 国际口腔医学杂志, 2021, 48(3): 347-353.
[11]	秦小茹,刘梦圆. 牙周病和心肌梗死发生风险相关性队列研究的Meta分析[J]. 国际口腔医学杂志, 2021, 48(2): 165-172.
[12]	郏乐铭,贾小玥,杨燃,周学东,徐欣. 益生菌制剂在牙周病防治中的应用进展[J]. 国际口腔医学杂志, 2020, 47(5): 515-521.
[13]	孔利心,任彪,程磊. 环氧合酶2/前列腺素E₂通路调控口腔肿瘤机制的研究进展[J]. 国际口腔医学杂志, 2020, 47(4): 431-438.
[14]	张琳琳,杜毅. 畸形舌侧沟的治疗进展[J]. 国际口腔医学杂志, 2020, 47(4): 458-462.
[15]	于林彤,宋光泰. 铒激光在儿童口腔医学中的应用[J]. 国际口腔医学杂志, 2020, 47(3): 351-355.