国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (5): 519-522.doi: 10.7518/gjkq.2017.05.005

• 牙周专栏 • 上一篇    下一篇

牙龈素促进牙龈卟啉单胞菌免疫逃逸的机制

李格格1, 潘佳慧1, 唐秋玲1, 刘歆婵2, 侯玉帛1, 于维先1   

  1. 1.吉林大学口腔医院牙周病科 吉林省牙发育及颌骨重塑与再生重点实验室 长春 130021;
    2.吉林大学口腔医院种植科 吉林省牙发育及颌骨重塑与再生重点实验室 长春 130021
  • 收稿日期:2016-11-19 修回日期:2017-05-16 出版日期:2017-09-01 发布日期:2017-09-01
  • 通讯作者: 于维先,教授,博士,Email：yu-wei-xian@163.com
  • 作者简介:李格格,硕士,Email：1099075958@qq.com
  • 基金资助:

    吉林省科技厅自然科学基金项目（20150101076JC）; 吉林省卫生技术创新项目（2016J073）; 国家自然科学基金面上项目（81- 570983）

Immune evasion strategies of Porphyromonas gingivalis via gingipains

Li Gege1, Pan Jiahui1, Tang Qiuling1, Liu Xinchan2, Hou Yubo1, Yu Weixian1   

  1. 1. Dept. of Periodontology, Hospital of Stomatology, Jilin University; Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China;
    2. Dept. of Dental Implantology, Hospital of Stomatology, Jilin University;Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2016-11-19 Revised:2017-05-16 Online:2017-09-01 Published:2017-09-01
  • Supported by:

    ; This study was supported by Funding from the Jilin Provincial Science and Technology Department(20150101076JC), Jilin Provincial Technology Innovation Projects(2016J073) and National Natural Science Foundation of China(81570983).

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摘要：

有关牙周炎病因的关键致病菌假说近年来引起学者们的关注,该假说认为牙龈卟啉单胞菌在牙周炎的发病过程中发挥着重要作用,是牙周炎的关键致病菌。牙龈素是牙龈卟啉单胞菌产生的重要致病因子之一,它可以协助牙龈卟啉单胞菌逃逸巨噬细胞、中性粒细胞及补体系统的杀伤作用。本文就牙龈素促进牙龈卟啉单胞菌免疫逃逸的机制相关研究进展作一综述,对这一机制的深入了解有助于进一步理解牙龈素的致病机制,同时也可以为牙周炎的防治探索新的途径。

关键词: 牙周炎, 牙龈卟啉单胞菌, 牙龈素, 免疫逃逸

Abstract:

The keystone-pathogen hypothesis about the etiology of periodontitis has attracted the attention of scholars in recent years. In this view, Porphyromonas gingivalis is considered as a keystone pathogen in the pathogenic progression of periodontitis. Gingipains generated by Porphyromonas gingivalis are key virulence factors, which could assist Porphyromonas gingivalis to escape the killing effects of macrophages, neutrophils and complement system. The aim of this literature review is to discuss the immune evasion strategies ofPorphyromonas gingivalis via gingipains. The exposition of this important mechanism may provide a further understanding of the pathogenic mechanism of gingipains, and lay a foundation for exploring new methods for the prevention and treatment of periodontitis.

Key words: periodontitis, Prophyromonas gingivalis, gingipain, immune evasion

中图分类号: 

  • R780.2
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