关键词: 仿生沉积, 钙磷涂层, 钛, 钛合金, 药物载体, 药物释放

Abstract:

In recent years, calcium-phosphate/bioactive coating molecules produced by biomimetic deposition technique have become an important research direction in the field of titanium surface modification. In biomimetic deposition technique, the coating is fabricated under physiological conditions of temperature and pH. Titanium implants were immersed into simulated body fluid(SBF) containing osteogenic molecules, such as growth factors, drugs, and proteins. These bioactive molecules can be incorporated into apatite and co-precipitated with calcium phosphate coating without loss of biological activity during the deposition process. The coating demonstrates good biocompatibility, osteoconductivity, and biodegradability. The drug-loading rate of the apatite coating is affected by the volume of SBF, concentration of protein/drugs, and protein isoelectric point, whereas the release behavior of protein(drugs) is affected by the drug loading rate, coating degradation rate, and adsorption positions of drugs and proteins in the coating. This article reviews current research progress on the characteristics of biomimetic deposition method, biological activity of calcium phosphate bioactive coatings, effect of bioactive molecules on the physicochemical properties of the biomimetic calcium-phosphate coating, and drug loading behavior of the biomimetic calcium-phosphate coating.

Key words: biomimetic deposition, calcium-phosphate coating, titanium, titanium alloy, drug carrier, drug