国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (1): 10-18.doi: 10.7518/gjkq.2023017

• 牙周专栏 • 上一篇    下一篇

静电纺丝纳米纤维在牙周再生中的应用

杨梦瑶1(),高现灵2,邓淑丽1()   

  1. 1.浙江大学医学院附属口腔医院牙体牙髓科 浙江大学口腔医学院 浙江省口腔疾病临床医学研究中心 浙江省口腔生物医学研究重点实验室 浙江大学癌症研究院 杭州 310006
    2.中山大学附属口腔医院牙体牙髓科 广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2022-05-16 修回日期:2022-09-28 出版日期:2023-01-01 发布日期:2023-01-09
  • 通讯作者: 邓淑丽
  • 作者简介:杨梦瑶，医师，硕士，Email：7519031@zju.edu.cn
  • 基金资助:
    国家自然科学基金(82001096);浙江省“尖兵”“领雁”研发攻关计划(2022C03060)

Application of electrospun nanofibers in periodontal regeneration

Yang Mengyao1(),Gao Xianling2,Deng Shuli1()   

  1. 1.Dept. of Cariology and Endodontics, Stomatological Hospital, School of Stomatology, Zhejiang University School of Me-dicine & Clinical Research Center for Oral Diseases of Zhejiang Province & Key Laboratory of Oral Biomedical Research of Zhejiang Province & Cancer Center of Zhejiang University, Hangzhou 310006, China
    2.Dept. of Cariology and Endodontics, Guanghua Hospital of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2022-05-16 Revised:2022-09-28 Online:2023-01-01 Published:2023-01-09
  • Contact: Shuli Deng
  • Supported by:
    National Natural Science Foundation of China(82001096);Research and Development Plan of Zhejiang Province’s “Top Soldiers” and “Leading Geese”(2022C03060)

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摘要：

静电纺丝技术通过高压电场制备纳米纤维，这类材料具有优良的生物相容性、生物降解性；同时具有高孔隙率和高比表面积，可模拟天然细胞外基质的结构，促进细胞增殖和分化；通过负载无机粒子、药物等活性物质可优化材料的生物性能。因此，静电纺丝纳米纤维已广泛应用于骨、软骨、神经、皮肤等组织再生，也是牙周组织再生研究中的热门材料。本文简要阐述了静电纺丝纳米纤维的制备过程，并从基质成分、生物活性和结构方面介绍其在牙周组织再生中的应用，旨在为其进一步研究和开发提供参考。

关键词: 静电纺丝, 纳米纤维, 牙周再生, 生物活性, 微观结构

Abstract:

Nanofibers are prepared by electrospinning technique through a high voltage electric field. These materials have good biocompatibility and biodegradability. Simultaneously, materials with high porosity and high specific surface area can simulate the structure of the natural extracellular matrix and thus promote cell proliferation and differentiation. The biological properties of materials can be optimized by loading inorganic particles, drugs, and other active substances. Therefore, electrospinning nanofibers have been widely used in the regeneration of bone, cartilage, nerve, skin, and other tissues, and are also popular materials in periodontal tissue regeneration. Hence, this review briefly describes the preparation process of electrospun nanofibers, and introduces their application in periodontal tissue regeneration from the aspects of matrix composition, biological activity, and structure, aiming to provide a reference for its further research and development.

Key words: electrospinning, nanofibers, periodontal regeneration, biological activity, microstructure

中图分类号: 

  • R 781.4

表 1

优化生物活性的各种静电纺丝纳米纤维"

种类活性成分优点缺点或需改善之处
生物陶瓷材料nHAp促进成骨混纺：需探索合适的比例；涂层：需控制涂层厚度、增加结合强度
β-TCP改善纤维力学性能，促进成骨需提高孔隙率、促进细胞黏附
药物需改善缓释效果、提高药效和生物活性
抗菌药物甲硝唑、氨苄西林、阿莫西林、盐酸四环素、盐酸强力霉素、替尼唑抑制牙周病菌
非甾体抗炎药阿司匹林、布洛芬、吡罗西康抑制炎症反应
植物提取物姜黄素、芹黄素、绿茶多酚、毛紫檀等抗炎、抗氧化
其他辛伐他汀、地塞米松、雷尼酸锶调节骨再生，促进成骨
金属及金属氧化物AgNPs抗菌需确认安全性
AuNPs促进成骨骨诱导性能较弱
Sr促进成骨需提高生物活性
CaO促进成骨降低力学性能
ZnO促进成骨、抗菌需确认安全性
胺基化的ZrO2增加强度、生物相容性佳需确认安全性
蛋白
生长因子BMPs促进成骨需改善缓释曲线、提高生物活性
PDGF、TGF、IGF促进创伤愈合及成骨
VEGF促进血管再生
功能蛋白AMPs抗菌需提高生物活性
FN促进细胞识别需改善包被方法
OCN促进矿化需体内试验验证效果
新型碳纳米材料GO改善力学性能、促进成骨体内不能降解
MWCNTs提高纤维的强度和韧性、骨传导性
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