国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (4): 380-385.doi: 10.7518/gjkq.2022057

• 牙发育专栏 • 上一篇    下一篇

时钟基因在牙齿发育中表达分布与调控机制的研究进展

赵曼竹1(),宋锦璘2()   

  1. 1.重庆医科大学附属口腔医院口腔综合科 重庆 401147
    2.重庆医科大学附属口腔医院 重庆 401147
  • 收稿日期:2021-10-19 修回日期:2022-03-02 出版日期:2022-07-01 发布日期:2022-06-28
  • 通讯作者: 宋锦璘
  • 作者简介:赵曼竹，博士，Email：501252@hospital.cqmu.edu.cn
  • 基金资助:
    国家自然科学基金青年科学基金(82000997);重庆自然科学基金面上项目(cstc2020jcyj-msxmX0018);2019年重庆市研究生导师团队资助项目(dstd201903)

Research progress on expression distribution and regulation mechanism of clock genes in tooth development

Zhao Manzhu1(),Song Jinlin2()   

  1. 1.Dept. of General Dentistry, Hospital of Stomatology, Chongqing Medical University, Chong-qing 401147, China
    2.Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China
  • Received:2021-10-19 Revised:2022-03-02 Online:2022-07-01 Published:2022-06-28
  • Contact: Jinlin Song
  • Supported by:
    National Natural Science Foundation of China Youth Science Foundation(82000997);Ge-neral Project of Chongqing Natural Science Foundation(cstc2020jcyj-msxmX0018);Project of Chongqing Graduate Tutor Team in 2019(dstd201903)

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摘要：

时间生物学的出现将生命科学研究由静态思维转向了动态思维。近年来时钟基因在口腔医学领域，尤其是牙齿发育中的调控作用与机制越来越受到学者们的关注。生物节律在牙齿硬组织中留下的痕迹包括釉柱横纹、芮氏线、牙本质冯·埃布纳线等，但时钟基因如何参与牙齿硬组织的生成调控及其分子机制仍未被完全揭示，一直是该领域研究的热点。目前的研究主要聚焦于时钟基因在牙发育过程中的动态表达规律和在牙齿硬组织矿化生成过程中的作用与机制，本文就时钟基因在牙齿发育中的表达分布特点、调控作用及机制的研究进展作一综述。

关键词: 时钟基因, 牙齿发育, 表达, 矿化, 调控机制

Abstract:

The emergence of chronobiology has brought the change from static thinking to dynamic thinking in life s-ciences. The effects and mechanism of clock genes in dentistry, especially those involved in tooth development, have been the focus of research. Dental hard tissue shows the characteristics of clock rhythm. The phenomenon of incremental growth lines in tooth (e.g., horizontal pattern of glaze column, Retzius and von Ebner lines) was the histologic evidence for this condition. However, the molecular mechanism of how clock genes participate in the regulation of periodic mine-ralization of dental hard tissues still requires elucidation and has long been one of the research focuses in this field. Recent studies have focused on the dynamic expression and regulation of clock genes in tooth morphogenesis, especially in dental hard tissue mineralization. This paper aims to review the current development in the studies of the expression distribution, role, and molecular mechanism of clock genes in tooth development.

Key words: clock gene, tooth development, expression, mineralization, regulation mechanism

中图分类号: 

  • R 78

图1

核心时钟基因的反馈抑制理论示意图"

图2

时钟基因和时钟控制基因的信号调控通路示意图"

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