国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (1): 12-18.doi: 10.7518/gjkq.2022015

• 材料学专栏 • 上一篇    下一篇

光响应水凝胶在生物医学领域应用的研究进展

梁屹(),裴锡波,万乾炳()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院修复科 成都 610041
  • 收稿日期:2021-04-12 修回日期:2021-09-13 出版日期:2022-01-01 发布日期:2022-01-07
  • 通讯作者: 万乾炳
  • 作者简介:梁屹,硕士,Email： 821868670@qq.com
  • 基金资助:
    国家自然科学基金(81970984)

Research progress on the biomedical applications of photosensitive hydrogels

Liang Yi(),Pei Xibo,Wan Qianbing()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-04-12 Revised:2021-09-13 Online:2022-01-01 Published:2022-01-07
  • Contact: Qianbing Wan
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81970984)

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摘要：

光响应水凝胶是对光响应的水膨胀性三维网状高分子聚合物。光响应水凝胶拥有类似天然细胞外基质的特性,通过光刺激可对其进行无接触的远程操纵和高精度的时空控制,因此在生物支架,药物递送,三维细胞培养及口腔医学等领域得到广泛的研究和应用。本文结合国内外文献,针对光响应水凝胶在生物医学领域的应用研究进展作一综述,同时总结光响应水凝胶目前所面临的挑战,并对其未来的发展方向进行展望。

关键词: 光响应水凝胶, 生物支架, 药物递送, 细胞封装

Abstract:

Photosensitive hydrogels are water swollen three-dimensional polymers, which are responsive to light. Photosensitive hydrogels have properties similar to natural extracellular matrix. They can be operated remotely without contact and spatiotemporally controlled with high precision by light stimulation. Accordingly, they are widely studied and applied in the fields of biological scaffold, drug delivery, three-dimensional cell culture and stomatology. This study reviews the applications of photosensitive hydrogels in biomedical fields based on domestic and foreign literature. Their potential for development and potential future challenges are also outlined.

Key words: photosensitive hydrogel, biological scaffold, drug delivery, cell encapsulation

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