国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (6): 703-710.doi: 10.7518/gjkq.2021110

• 综述 • 上一篇    下一篇

甲状旁腺激素及甲状旁腺素相关肽在牙齿硬组织形成中的作用

李媛媛(),陈俊宇,蔡和,万乾炳()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院修复科 成都 610041
  • 收稿日期:2021-02-21 修回日期:2021-07-02 出版日期:2021-11-01 发布日期:2021-10-28
  • 通讯作者: 万乾炳
  • 作者简介:李媛媛,硕士,Email: 2962025647@qq.com
  • 基金资助:
    国家自然科学基金(81970984)

Effects of parathyroid hormone and parathyroid hormone-related peptide on hard dental tissue formation

Li Yuan-yuan(),Chen Junyu,Cai He,Wan Qianbing()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-02-21 Revised:2021-07-02 Online:2021-11-01 Published:2021-10-28
  • Contact: Qianbing Wan
  • Supported by:
    National Natural Science Foundation of China(81970984)

摘要:

甲状旁腺激素(PTH)及甲状旁腺素相关肽(PTHrP)是体内钙磷稳态的重要调节因子,影响着牙体硬组织的形成和矿化。此外,PTHrP作为介导上皮-间充质相互作用的生长因子,以旁分泌、自分泌的形式参与调节牙胚细胞的增殖分化,在牙齿发育早期发挥着重要作用。本文结合国内外文献,针对甲状旁腺激素和甲状旁腺素相关肽在牙齿硬组织形态发生及矿化中的作用作一综述,以期为它们用于牙齿发育异常及牙体硬组织修复方面的研究提供参考。

关键词: 甲状旁腺激素, 甲状旁腺素相关肽, 牙齿硬组织, 矿化

Abstract:

Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) are critical regulators of calcium and phosphorus balance, which affects the formation and mineralization of tooth tissue. PTHrP, as the growth factor that mediates epithelial-mesenchymal interaction, plays an important role in regulating the proliferation and differentiation of tooth germ cells in an autocrine or paracrine manner. This review provides an overview of the effects of parathyroid hormone and PTHrP on the formation and mineralization of hard dental tissue, which could be beneficial to their potential applications in dental abnormalities and hard tissue defect.

Key words: parathyroid hormone, parathyroid hormone-related peptide, tooth hard tissue, mineralization

中图分类号: 

  • R78
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