国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (6): 690-695.doi: 10.7518/gjkq.2021106

• 综述 • 上一篇    下一篇

牙源性间充质干细胞应用于牙周组织缺损修复的研究进展

施培磊(),于晨浩,谢旭东,吴亚菲,王骏()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2021-02-24 修回日期:2021-07-16 出版日期:2021-11-01 发布日期:2021-10-28
  • 通讯作者: 王骏
  • 作者简介:施培磊,博士,Email: shipeilei0222@outlook.com
  • 基金资助:
    国家自然科学基金(82071127);国家自然科学基金(81700980);四川省科技计划项目(2019YJ0097)

Research progress on the application of dental-derived mesenchymal stem cells in periodontal defect repair

Shi Peilei(),Yu Chenhao,Xie Xudong,Wu Yafei,Wang Jun()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-02-24 Revised:2021-07-16 Online:2021-11-01 Published:2021-10-28
  • Contact: Jun Wang
  • Supported by:
    National Natural Science Foundation of China(82071127);National Natural Science Foundation of China(81700980);Sichuan Province Science and Technology Support Program(2019YJ0097)

摘要:

牙周炎是以牙周组织破坏为特征的慢性感染性疾病,是成人失牙的主要原因。牙周软硬组织的复杂结构决定了牙周组织修复的困难。牙源性间充质干细胞的自我更新、多向分化能力和易获取性使其成为牙周组织修复的理想细胞来源。随着细胞膜片技术、生物支架材料、3D打印技术的发展,牙源性间充质干细胞作为种子细胞在修复牙周组织缺损方面展现了较好的潜能。本文将对现阶段牙源性间充质干细胞应用于牙周组织修复的研究进展进行综述。

关键词: 牙源性间充质干细胞, 牙周组织修复, 组织工程, 牙周炎

Abstract:

Periodontitis is a chronic infectious disease characterized by the destruction of periodontal tissue and is the most common cause of tooth loss among adults. The periodontium is a complex structure composed of soft and hard tissues; hence, the regeneration of its tissues is a challenging task. Self-renewal, multipotency, and accessibility make dental-derived mesenchymal stem cells an attractive source for periodontal tissue regeneration. With the development of cell-sheet engineering, biomaterial scaffolds, and 3D printing, dental-derived mesenchymal stem cells show great potential as seed cells in repairing periodontal tissue defects. This paper reviews the research progress on the application of dental-derived mesenchymal stem cells in periodontal defect repair.

Key words: dental-derived mesenchymal stem cell, periodontal tissue repair, tissue engineering, periodontitis

中图分类号: 

  • Q254
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