国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (6): 683-689.doi: 10.7518/gjkq.2021105

• 综述 • 上一篇    下一篇

混合光源系统用于活髓牙漂白的临床研究进展

张雪雯1(),李聪2,徐小茵1,高静3,申静3()   

  1. 1.天津医科大学口腔医学院口腔医学系 天津 300070
    2.南开大学医学院口腔医学系 天津 300071
    3.天津市口腔医院国际诊疗中心 天津 300041
  • 收稿日期:2021-02-12 修回日期:2021-07-10 出版日期:2021-11-01 发布日期:2021-10-28
  • 通讯作者: 申静
  • 作者简介:张雪雯,医师,硕士,Email: 2306744831@qq.com

Hybrid light source in vital dental bleaching

Zhang Xuewen1(),Li Cong2,Xu Xiaoyin1,Gao Jing3,Shen Jing3()   

  1. 1. Dept. of Stomatology, School of Stomatology, Tianjin Medical University, Tianjin 300070, China
    2. Dept. of Stomatology, School of Medicine, Nankai University, Tianjin 300071, China
    3. International Clinic Center, Stomatological Hospital of Tianjin, Tianjin 300041, China
  • Received:2021-02-12 Revised:2021-07-10 Online:2021-11-01 Published:2021-10-28
  • Contact: Jing Shen

摘要:

自激光应用于活髓牙漂白,其显示出巨大的应用潜力,但同时也带来了髓腔升温、牙髓组织损伤、牙齿敏感等一系列的潜在风险。因此,大量的研究旨在寻求一种更加安全、可控的临床漂白方案,这些研究涉及了不同类型光源、不同光强度、不同浓度的漂白剂以及不同的漂白步骤。其中,应用发光二极管(LED)与低强度激光的混合光系统漂白方案因其较保守的漂白参数受到较大的关注。本文将对这一漂白系统的应用效果及安全性作一综述,以探讨其在活髓牙漂白中有效性及安全性的可能优势。

关键词: 牙齿漂白, 混合光, 低浓度过氧化氢, 安全性, 有效性

Abstract:

Laser shows great potential application in vital dental bleaching but includes many potential risks, such as temperature increase in pulp cavity, damage to pulp tissues, and tooth sensitivity. Therefore, many studies involving different light types, light powers, bleaching agent concentrations, and bleaching procedures have been conducted to develop a safe and predictable process for clinical bleaching. The application of light-emitting diode (LED)-low level laser hybrid light source has attracted attention due to its conservative bleaching parameters. In this paper, the efficacy and safety of this novel bleaching system are reviewed to explore its possible advantages in vital dental bleaching.

Key words: dental bleaching, hybrid light, low concentration hydrogen peroxide, safety, effectiveness

中图分类号: 

  • R312

表1

常用混合光系统漂白方案的参数"

参考文献 光源设备(波长及功率) 功率密度/
mW·cm-2
光照面积/
cm2
漂白凝胶 光敏剂 漂白程序 随访时间
[15] LED(470 nm、1 800 mW)+激光(808 nm、600 mW) 300 8.5 6%和15% H2O2 均含TiO_N 3次就诊,每次重复3个10 min 1周、6个月
[16] LED(470 nm、1 500 mW)+激光(808 nm、300 mW) - - 6% H2O2 TiO2 3次就诊,每次重复2个12 min 1周、1个月、1、2年
[17] LED(470 nm、350 mW·cm-2)+激光(810 nm、200 mW·cm-2 - - 25%和35% H2O2 3次就诊,每次重复3个7.5 min 1周、1个月、1、3年
[18] LED(470 nm、1 500 mW)+激光(808 nm、300 mW) - - 6% H2O2 TiO2 3次就诊,每次重复2个12 min 1周、1个月、
1年
[19] LED+激光(总功率1 500 mW) - - 6% H2O2 TiO2 3次就诊,每次重复2个12 min 1周、1、9个月
[20] LED(470 nm、1 800 mW)+激光(808 nm、600 mW) 300 8.5 6% H2O2 TiO2 3次就诊,每次重复2个12 min;1次就诊,每次重复2个36 min 1周、1个月
[21] LED(470 nm、1 800 mW)+激光(810 nm、600 mW) 300 8.5 6% H2O2 TiO_N 2次就诊,每次重复2个12 min 无长期随访
[22] LED+激光(总功率1 500 mW) - - 6% H2O2 N_TiO2 3次就诊,每次重复2个12 min 1周、1个月
[23] LED(450 nm、400 mW)+激光(808 nm、100 mW) - - 15%和35% H2O2 仅15% H2O2
含N_TiO2
3次就诊,每次重复3个12 min 1周、1个月
[24] LED(470 nm、1 800 mW)+激光(808 nm、600 mW) 300 8.5 15% H2O2 TiO_N 3次就诊,每次重复3个16 min 无长期随访

图1

混合光源系统漂白机制示意图 PS:光敏剂(photosensitizer);ROS:活性氧物质(reactive oxygen species)。"

[1] Carey CM. Tooth whitening: what we now know[J]. J Evid Based Dent Pract, 2014, 14(Suppl):70-76.
[2] Dionysopoulos D, Strakas D, Koliniotou-Koumpia E, et al. Effect of Er, Cr: YSGG laser irradiation on bovine enamel surface during in-office tooth blea-ching ex vivo[J]. Odontology, 2017, 105(3):320-328.
doi: 10.1007/s10266-016-0273-2 pmid: 27743231
[3] Al-Maliky MA. Clinical investigation of 940 nm dio-de laser power bleaching: an in vivo study[J]. J Lasers Med Sci, 2019, 10(1):33-36.
doi: 10.15171/jlms.2019.05 pmid: 31360366
[4] Shahabi S, Assadian H, Mahmoudi Nahavandi A, et al. Comparison of tooth color change after bleaching with conventional and different light-activated methods[J]. J Lasers Med Sci, 2018, 9(1):27-31.
doi: 10.15171/jlms.2018.07 pmid: 29399308
[5] Maran BM, Burey A, de Paris Matos T , et al. In-office dental bleaching with light vs. without light: a systematic review and meta-analysis[J]. J Dent, 2018, 70:1-13.
doi: 10.1016/j.jdent.2017.11.007
[6] Maran BM, Ziegelmann PK, Burey A, et al. Diffe-rent light-activation systems associated with dental bleaching: a systematic review and a network meta-analysis[J]. Clin Oral Investig, 2019, 23(4):1499-1512.
doi: 10.1007/s00784-019-02835-x
[7] Mondelli RF, Soares AF, Pangrazio EG, et al. Evalua-tion of temperature increase during in-office blea-ching[J]. J Appl Oral Sci, 2016, 24(2):136-141.
doi: 10.1590/1678-775720150154
[8] Benetti F, Lemos CAA, de Oliveira Gallinari M , et al. Influence of different types of light on the response of the pulp tissue in dental bleaching: a systematic review[J]. Clin Oral Investig, 2018, 22(4):1825-1837.
doi: 10.1007/s00784-017-2278-9
[9] Ergin E, Ruya Yazici A, Kalender B, et al. In vitro comparison of an Er: YAG laser-activated bleaching system with different light-activated bleaching systems for color change, surface roughness, and ena-mel bond strength[J]. Lasers Med Sci, 2018, 33(9):1913-1918.
doi: 10.1007/s10103-018-2555-0
[10] Lopes FC, Roperto R, Akkus A, et al. Effect of laser activated bleaching on the chemical stability and morphology of intracoronal dentin[J]. Arch Oral Biol, 2018, 86:40-45.
doi: 10.1016/j.archoralbio.2017.10.023
[11] Saberi S, Rouzsaz M, Shafie F, et al. The effect of laser-activated bleaching with 445 nm and 915 nm diode lasers on enamel micro-hardness; an in vitro study[J]. Photodiagnosis Photodyn Ther, 2020, 31:101952.
[12] SoutoMaior JR, de Moraes S, Lemos C, et al. Effectiveness of light sources on in-office dental blea-ching: a systematic review and meta-analyses[J]. Oper Dent, 2019, 44(3):E105-E117.
doi: 10.2341/17-280-L
[13] Alshammery S. Evaluation of light activation on in-office dental bleaching: a systematic review[J]. J Contemp Dent Pract, 2019, 20(11):1355-1360.
pmid: 31892691
[14] Mosca RC, Ong AA, Albasha O, et al. Photobiomodulation therapy for wound care: a potent, noninvasive, photoceutical approach[J]. Adv Skin Wound Care, 2019, 32(4):157-167.
doi: 10.1097/01.ASW.0000553600.97572.d2
[15] Mounika A, Mandava J, Roopesh B, et al. Clinical evaluation of color change and tooth sensitivity with in-office and home bleaching treatments[J]. Indian J Dent Res, 2018, 29(4):423-427.
doi: 10.4103/ijdr.IJDR_688_16
[16] Bersezio C, Martín J, Angel P, et al. Teeth whitening with 6% hydrogen peroxide and its impact on quality of life: 2 years of follow-up[J]. Odontology, 2019, 107(1):118-125.
doi: 10.1007/s10266-018-0372-3
[17] Mondelli R, Rizzante F, Rosa ER, et al. Effectiveness of LED/laser irradiation on in-office dental bleaching after three years[J]. Oper Dent, 2018, 43(1):31-37.
doi: 10.2341/16-208-C pmid: 29284097
[18] Vildósola P, Bottner J, Avalos F, et al. Teeth blea-ching with low concentrations of hydrogen peroxide (6%) and catalyzed by LED blue (450±10 nm) and laser infrared (808±10 nm) light for in-office treatment: randomized clinical trial 1-year follow-up[J]. J Esthet Restor Dent, 2017, 29(5):339-345.
doi: 10.1111/jerd.12318 pmid: 28712152
[19] Fernández E, Bersezio C, Bottner J, et al. Longevity, esthetic perception, and psychosocial impact of teeth bleaching by low (6%) hydrogen peroxide concentration for in-office treatment: a randomized cli-nical trial[J]. Oper Dent, 2017, 42(1):41-52.
doi: 10.2341/15-335-C pmid: 27571237
[20] Vildósola P, Vera F, Ramírez J, et al. Comparison of effectiveness and sensitivity using two in-office bleaching protocols for a 6% hydrogen peroxide gel in a randomized clinical trial[J]. Oper Dent, 2017, 42(3):244-252.
doi: 10.2341/16-043-C pmid: 28467262
[21] Bortolatto JF, Trevisan TC, Bernardi PS, et al. A no-vel approach for in-office tooth bleaching with 6% H2O2/TiO_N and LED/laser system-a controlled, triple-blinded, randomized clinical trial[J]. Lasers Med Sci, 2016, 31(3):437-444.
doi: 10.1007/s10103-016-1866-2
[22] Martín J, Vildósola P, Bersezio C, et al. Effectiveness of 6% hydrogen peroxide concentration for tooth bleaching-a double-blind, randomized clinical trial[J]. J Dent, 2015, 43(8):965-972.
doi: 10.1016/j.jdent.2015.05.011 pmid: 26057085
[23] Martín J, Ovies N, Cisternas P, et al. Can an LED-laser hybrid light help to decrease hydrogen peroxide concentration while maintaining effectiveness in teeth bleaching[J]. Laser Phys, 2015, 25(2):025608.
doi: 10.1088/1054-660X/25/2/025608
[24] Bortolatto JF, Pretel H, Floros MC, et al. Low concentration H2O2/TiO_N in office bleaching: a randomized clinical trial[J]. J Dent Res, 2014, 93(7 Suppl):66S-71S.
doi: 10.1177/0022034514537466
[25] Lima SNL, Ribeiro IS, Grisotto MA, et al. Evaluation of several clinical parameters after bleaching with hydrogen peroxide at different concentrations: a randomized clinical trial[J]. J Dent, 2018, 68:91-97.
doi: 10.1016/j.jdent.2017.11.008
[26] De Moor RJ, Verheyen J, Diachuk A, et al. Insight in the chemistry of laser-activated dental bleaching[J]. Sci World J, 2015, 2015:650492.
[27] Lehmann K, Devigus A, Wentaschek S, et al. Comparison of visual shade matching and electronic co-lor measurement device[J]. Int J Esthet Dent, 2017, 12(3):396-404.
pmid: 28717795
[28] Bersezio C, Ledezma P, Estay J, et al. Color regression and maintenance effect of intracoronal white-ning on the quality of life: RCT-a one-year follow-up study[J]. Oper Dent, 2019, 44(1):24-33.
doi: 10.2341/17-288-C pmid: 30059269
[29] Vano M, Derchi G, Barone A, et al. Tooth bleaching with hydrogen peroxide and nano-hydroxyapatite: a 9-month follow-up randomized clinical trial[J]. Int J Dent Hygiene, 2015, 13(4):301-307.
doi: 10.1111/idh.2015.13.issue-4
[30] Ferraz NKL, Nogueira LC, Neiva IM, et al. Longe-vity, effectiveness, safety, and impact on quality of life of low-concentration hydrogen peroxides in-office bleaching: a randomized clinical trial[J]. Clin Oral Investig, 2019, 23(5):2061-2070.
doi: 10.1007/s00784-018-2607-7
[31] Lilaj B, Dauti R, Agis H, et al. Comparison of blea-ching products with up to 6% and with more than 6% hydrogen peroxide: whitening efficacy using BI and WID and side effects-an in vitro study[J]. Front Physiol, 2019, 10:919.
doi: 10.3389/fphys.2019.00919
[32] Lima AF, Ribeiro AP, Basso FG, et al. Effect of low-level laser therapy on odontoblast-like cells exposed to bleaching agent[J]. Lasers Med Sci, 2014, 29(5):1533-1538.
doi: 10.1007/s10103-013-1309-2
[33] Lima AF, Basso FG, Ribeiro AP, et al. Effects of laser irradiation on pulp cells exposed to bleaching agents[J]. Photochem Photobiol, 2014, 90(1):201-206.
doi: 10.1111/php.2013.90.issue-1
[34] Gonçalves RS, Costa CA, Soares DG, et al. Effect of different light sources and enamel preconditio-ning on color change, H2O2 penetration, and cytoto-xicity in bleached teeth[J]. Oper Dent, 2016, 41(1):83-92.
doi: 10.2341/14-364-L pmid: 26266650
[35] Coldebella CR, Ribeiro AP, Sacono NT, et al. Indirect cytotoxicity of a 35% hydrogen peroxide blea-ching gel on cultured odontoblast-like cells[J]. Braz Dent J, 2009, 20(4):267-274.
doi: S0103-64402009000400001 pmid: 20069247
[36] Dias Ribeiro AP, Sacono NT, Lessa FC, et al. Cytotoxic effect of a 35% hydrogen peroxide bleaching gel on odontoblast-like MDPC-23 cells[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2009, 108(3):458-464.
doi: 10.1016/j.tripleo.2009.05.006 pmid: 19716511
[37] Trindade FZ, Ribeiro AP, Sacono NT, et al. Trans-enamel and trans-dentinal cytotoxic effects of a 35% H2O2 bleaching gel on cultured odontoblast cell lines after consecutive applications[J]. Int Endod J, 2009, 42(6):516-524.
doi: 10.1111/j.1365-2591.2009.01544.x pmid: 19460001
[38] Dantas CMG, Vivan CL, Ferreira LS, et al. In vitro effect of low intensity laser on the cytotoxicity produced by substances released by bleaching gel[J]. Braz Oral Res, 2010, 24(4):460-466.
doi: 10.1590/S1806-83242010000400015
[39] Moosavi H, Arjmand N, Ahrari F, et al. Effect of low-level laser therapy on tooth sensitivity induced by in-office bleaching[J]. Lasers Med Sci, 2016, 31(4):713-719.
doi: 10.1007/s10103-016-1913-z
[40] Asnaashari M, Moeini M. Effectiveness of lasers in the treatment of dentin hypersensitivity[J]. J Lasers Med Sci, 2013, 4(1):1-7.
pmid: 25606300
[41] Rezazadeh F, Dehghanian P, Jafarpour D. Laser effects on the prevention and treatment of dentinal hypersensitivity: a systematic review[J]. J Lasers Med Sci, 2019, 10(1):1-11.
doi: 10.15171/jlms.2019.01 pmid: 31360362
[42] de Paula B, Alencar C, Ortiz M, et al. Effect of photobiomodulation with low-level laser therapy combined with potassium nitrate on controlling post-bleaching tooth sensitivity: clinical, randomized, controlled, double-blind, and split-mouth study[J]. Clin Oral Investig, 2019, 23(6):2723-2732.
doi: 10.1007/s00784-018-2715-4
[43] Alencar CM, de Paula BLF, Araújo JLN, et al. Effect of low-level laser therapy combined with 5 000 parts per million fluoride dentifrice on postbleaching sensitivity: a clinical, randomized, and double-blind study[J]. J Esthet Restor Dent, 2018, 30(4):352-359.
doi: 10.1111/jerd.2018.30.issue-4
[44] Klaric E, Rakic M, Sever I, et al. Enamel and dentin microhardness and chemical composition after experimental light-activated bleaching[J]. Oper Dent, 2015, 40(4):E132-E141.
doi: 10.2341/14-148-L
[45] Loiola AB, Souza-Gabriel AE, Scatolin RS, et al. Impact of hydrogen peroxide activated by lighting-emitting diode/laser system on enamel color and microhardness: an in situ design[J]. Contemp Clin Dent, 2016, 7(3):312-316.
doi: 10.4103/0976-237X.188544
[46] Ranjbar Omrani L, Khoshamad S, Tabatabaei Ghom-she E, et al. In vitro effect of bleaching with 810 nm and 980 nm diode laser on microhardness of self-cure and light-cure glass ionomer cements[J]. J Lasers Med Sci, 2017, 8(4):191-196.
doi: 10.15171/jlms.2017.35 pmid: 29071026
[47] Surmelioglu D, Yalcin ED, Orhan K. Analysis of enamel structure and mineral density after different bleaching protocols using micro-computed tomography[J]. Acta Odontol Scand, 2020, 78(8):618-625.
doi: 10.1080/00016357.2020.1807047
[48] Ceyda A, Müjde S, Yusuf OO, et al. Evaluation of the shear bond strength of resin cement to enamel after bleaching with Er: YAG and diode laser[J]. Adv Compos Lett, 2020, 29(3). doi: 10.1177/2633366X19899961
doi: 10.1177/2633366X19899961
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