国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (6): 675-682.doi: 10.7518/gjkq.2021083

• 综述 • 上一篇    下一篇

外伤年轻恒牙的牙髓状态判断及治疗选择

郜慧慧1(),邓淑丽2,何新敏2,胡济安2()   

  1. 1.浙江大学医学院口腔系 浙江大学医学院附属口腔医院牙体牙髓科 浙江省口腔生物医学研究重点实验室 杭州 310006
    2.浙江大学医学院附属口腔医院牙体牙髓科 浙江省口腔生物医学研究重点实验室 杭州 310006
  • 收稿日期:2020-12-10 修回日期:2021-05-14 出版日期:2021-11-01 发布日期:2021-10-28
  • 通讯作者: 胡济安
  • 作者简介:郜慧慧,住院医师,学士,Email: 21818478@zju.edu.cn
  • 基金资助:
    国家卫生健康委员会科研基金(WKJ-ZJ-1624);浙江省教育厅一般科研项目(Y201942154)

Evaluation of pulp status and selection of treatment in young permanent teeth after trauma

Gao Huihui1(),Deng Shuli2,He Xinmin2,Hu Ji,an2()   

  1. 1. Dept. of Dentistry, School of Medicine, Zhejiang University, Dept. of Cariology and En-dodontics, The Affiliated Stomatological Hospital, School of Medicine, Zhejiang University, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China
    2. Dept. of Cariology and Endodontics, The Affiliated Stomatological Hospital, School of Medicine, Zhejiang University, Key Laboratory of Oral Biomedical Research of Zhe-jiang Province, Hangzhou 310006, China
  • Received:2020-12-10 Revised:2021-05-14 Online:2021-11-01 Published:2021-10-28
  • Contact: Ji,an Hu
  • Supported by:
    National Health and Family Planning Commission Fund(WKJ-ZJ-1624);Zhejiang Education Department of General Scientific Research Project(Y201942154)

摘要:

牙外伤是指外力造成的牙体硬组织和(或)根尖周组织的损伤,任何类型的牙外伤都可能会造成牙髓组织病理性改变,从而影响患牙的预后及长期保存,尤其是年轻恒牙,存在牙根发育不完全、根尖孔粗大、牙髓血供丰富等独特的解剖及生理学特点,这为其外伤后的牙髓治疗带来了巨大挑战,同时也为其活髓保存及牙髓再生提供了生理学基础。本文就年轻恒牙外伤后的不同牙髓状态及其相应活髓保存治疗方法作一综述,以期为口腔临床医生提供治疗选择的依据。

关键词: 牙外伤, 年轻恒牙, 牙髓状态, 活髓保存治疗

Abstract:

Tooth trauma is the damage of hard tissue and (or) periapical tissue caused by external force. It may induce pathological changes of dental-pulp tissue, thereby affecting the prognosis and long-term preservation of the affected teeth. In particular, permanent teeth have the unique anatomical and physiological characteristics of incomplete root deve-lopment, large apical foramen, and adequate blood supply. Once young permanent teeth suffer from trauma, the treatment of the affected teeth becomes greatly challenging. It also provides a physiological basis for the preservation of living pulp and pulp regeneration. In this paper, we review the different pulp states of young permanent teeth after trauma and the corresponding vital-pulp preservation treatment to provide a basis for oral clinicians to select the appropriate treatment stra-tegy.

Key words: tooth trauma, immature permanent teeth, dental-pulp state, vital pulp therapy

中图分类号: 

  • R781.33

表1

常见年轻恒牙外伤类型中不同牙髓状态下的治疗方案"

项目 硬组织损伤 牙周组织损伤
简单冠折 复杂冠/冠-根折 牙震荡 不完全脱位损伤 全脱位损伤 嵌入型损伤
保存
活髓
方式
1)边缘磨光/充填修复;
2)牙本质封闭/间接盖髓+充填修复
1)露髓孔直径<0.5 mm、时间短、断面干净:DPC[28];
2)露髓孔直径>0.5 mm、暴露时间长:活髓切断术
定期监测牙髓状态,
牙髓坏死概率较小[13]
定期监测牙髓状态,
可恢复牙髓血流供应[6]
定期监测牙髓状态,
可恢复牙髓血流供应[6]
定期监测牙髓状态,
牙髓坏死概率大[13]
随访
内容
临床检查:牙冠颜色、叩诊、松动度、根尖周是否有窦道/瘘管、牙髓活力测试等 影像学检查:根尖周组织及牙根发育情况、是否存在牙根吸收、髓腔闭锁等
不良
结果
处理
牙髓炎:根据炎症范围采用牙髓切断术[36] 牙髓坏死及根尖周病变:1)当牙根长度<2/3、根尖孔直径>1 mm时,行牙髓血运重建术[56];2)根尖孔直径0.5~1.0 mm、患牙有足够的根管壁厚度及长度,行根尖诱导成形术[45,46];3)牙根发育接近完成,根尖孔直径<0.5 mm或已行牙髓血运重建术及根尖诱导成形术后未形成明显根尖止点时,行根尖屏障术
[1] Mustafa Ali M, Al Zoubi L, Eissa M, et al. Changes in the epidemiology and aetiology of dental trauma-tic injuries in permanent teeth in children before and after German unification[J]. Eur Arch Paediatr Dent, 2019, 20(1):41-46.
doi: 10.1007/s40368-018-0383-3
[2] James V, Vandersluis YR, Zhang EWJ, et al. Dental injuries in younger emergency department patients[J]. CJEM, 2018, 20(3):425-431.
doi: 10.1017/cem.2017.52
[3] Rêgo ICQ, Vilarinho SMM, Rodrigues CKF, et al. Oral and cranio-maxillofacial trauma in children and adolescents in an emergency setting at a Brazilian hospital[J]. Dent Traumatol, 2020, 36(2):167-173.
doi: 10.1111/edt.v36.2
[4] Yu CY, Abbott PV. Responses of the pulp, periradi-cular and soft tissues following trauma to the permanent teeth[J]. Aust Dent J, 2016, 61(Suppl 1):39-58.
doi: 10.1111/adj.2016.61.issue-S1
[5] Angelova Volponi A, Zaugg LK, Neves V, et al. Too-th repair and regeneration[J]. Curr Oral Health Rep, 2018, 5(4):295-303.
doi: 10.1007/s40496-018-0196-9
[6] Andreasen FM, Yu ZJ, Thomsen BL. Relationship between pulp dimensions and development of pulp necrosis after luxation injuries in the permanent dentition[J]. Dent Traumatol, 1986, 2(3):90-98.
doi: 10.1111/edt.1986.2.issue-3
[7] Taschieri S, Del Fabbro M, Samaranayake L, et al. Microbial invasion of dentinal tubules: a literature review and a new perspective[J]. J Investig Clin Dent, 2014, 5(3):163-170.
doi: 10.1111/jicd.12109
[8] Moradi S, Bidar M, Zarrabi MH, et al. Dental pulp reaction to exposure at different time intervals in open apex canine teeth of cats[J]. Iran Endod J, 2009, 4(2):49-52.
[9] Abbott PV. Diagnosis and management of transverse root fractures[J]. J Endod, 2019, 45(12s):S13-S27.
doi: 10.1016/j.joen.2019.05.009
[10] Andreasen FM, Pedersen BV. Prognosis of luxated permanent teeth: the development of pulp necrosis[J]. Endod Dent Traumatol, 1985, 1(6):207-220.
pmid: 3867505
[11] 管悦, 秦满. 年轻恒牙脱出性损伤后牙髓预后及相关因素分析[J]. 中华口腔医学杂志, 2008, 43(9):520-523.
Guan Y, Qin M. A retrospective study of pulp hea-ling after luxation injuries[J]. Chin J Stomatol, 2008, 43(9):520-523.
[12] 黄超, 刘艳丽, 王伟, 等. 外伤牙髓保存的研究进展[J]. 牙体牙髓牙周病学杂志, 2016, 26(5):318-321, 324.
Huang C, Liu YL, Wang W, et al. Pulp preservation following dental trauma[J]. Chin J Conserv Dent, 2016, 26(5):318-321, 324.
[13] Spinas E, Pipi L, Dettori C. Extrusive luxation injuries in young patients: a retrospective study with 5-year follow-up[J]. Dent J, 2020, 8(4):136.
doi: 10.3390/dj8040136
[14] Haug SR, Heyeraas KJ. Modulation of dental inflammation by the sympathetic nervous system[J]. J Dent Res, 2006, 85(6):488-495.
pmid: 16723642
[15] Andreasen FM, Kahler B. Pulpal response after acu-te dental injury in the permanent dentition: clinical implications-a review[J]. J Endod, 2015, 41(3):299-308.
doi: 10.1016/j.joen.2014.11.015 pmid: 25601716
[16] Ersahan S, Sabuncuoglu FA, Oktay EA. The efficacy of laser Doppler flowmetry, electric pulp test and cold test in diagnosing revascularization of extrusi-vely luxated immature maxillary incisors[J]. Pak J Med Sci, 2018, 34(4):787-793.
doi: 10.12669/pjms.344.15524 pmid: 30190729
[17] Ahn SY, Kim D, Park SH. Long-term prognosis of pulpal status of traumatized teeth exhibiting contradictory results between pulp sensibility test and ultrasound Doppler flowmetry: a retrospective study[J]. J Endod, 2018, 44(3):395-404.
doi: 10.1016/j.joen.2017.12.001
[18] Bargrizan M, Ashari MA, Ahmadi M, et al. The use of pulse oximetry in evaluation of pulp vitality in immature permanent teeth[J]. Dent Traumatol, 2016, 32(1):43-47.
doi: 10.1111/edt.12215 pmid: 26358664
[19] Caldeira CL, Barletta FB, Ilha MC, et al. Pulse oxi-metry: a useful test for evaluating pulp vitality in traumatized teeth[J]. Dent Traumatol, 2016, 32(5):385-389.
doi: 10.1111/edt.12279 pmid: 27140332
[20] Anusha B, Madhusudhana K, Chinni SK, et al. Assessment of pulp oxygen saturation levels by pulse oximetry for pulpal diseases-a diagnostic study[J]. J Clin Diagn Res, 2017, 11(9): ZC36-ZC39.
[21] Souza RA, Gomes SCN, Dantas JDCP, et al. Importance of the diagnosis in the pulpotomy of immature permanent teeth[J]. Braz Dent J, 2007, 18(3):244-247.
doi: 10.1590/S0103-64402007000300013
[22] Andreasen FM. Pulpal healing after luxation injuries and root fracture in the permanent dentition[J]. Endod Dent Traumatol, 1989, 5(3):111-131.
pmid: 2699588
[23] Ning T, Shao J, Zhang X, et al. Ageing affects the proliferation and mineralization of rat dental pulp stem cells under inflammatory conditions[J]. Int Endod J, 2020, 53(1):72-83.
doi: 10.1111/iej.13205 pmid: 31419325
[24] Li Y, Zhao S, Nan X, et al. Repair of human perio-dontal bone defects by autologous grafting stem cells derived from inflammatory dental pulp tissues[J]. Stem Cell Res Ther, 2016, 7(1):141.
doi: 10.1186/s13287-016-0404-2
[25] Kodonas K, Fardi A, Gogos C, et al. Scientometric analysis of vital pulp therapy studies[J]. Int Endod J, 2021, 54(2):220-230.
doi: 10.1111/iej.v54.2
[26] Olsburgh S, Jacoby T, Krejci I. Crown fractures in the permanent dentition: pulpal and restorative considerations[J]. Dent Traumatol, 2002, 18(3):103-115.
pmid: 12110103
[27] Katge FA, Patil DP. Comparative analysis of 2 cal-cium silicate-based cements (biodentine and mineral trioxide aggregate) as direct pulp-capping agent in young permanent molars: a split mouth study[J]. J Endod, 2017, 43(4):507-513.
doi: 10.1016/j.joen.2016.11.026
[28] Kratunova E, Silva D. Pulp therapy for primary and immature permanent teeth: an overview[J]. Gen Dent, 2018, 66(6):30-38.
pmid: 30444704
[29] Hatipoglu Ö. Factors affecting the decision-making of direct pulp capping procedures amongst Turkish dental practitioners[J]. Eur Endod J, 2018, 3(3):167-173.
[30] Kunert M, Lukomska-Szymanska M. Bio-inductive materials in direct and indirect pulp capping-a review article[J]. Materials, 2020, 13(5):1204.
doi: 10.3390/ma13051204
[31] Paula AB, Laranjo M, Marto CM, et al. Evaluation of dentinogenesis inducer biomaterials: an in vivo study[J]. J Appl Oral Sci, 2020, 28:e20190023.
[32] Tanalp J, Karapınar-Kazandağ M, Dölekoğlu S, et al. Comparison of the radiopacities of different root-end filling and repair materials[J]. Sci World J, 2013, 2013:594950.
[33] Mahgoub N, Alqadasi B, Aldhorae K, et al. Compa-rison between iRoot BP Plus (EndoSequence root repair material) and mineral trioxide aggregate as pulp-capping agents: a systematic review[J]. J Int Soc Prev Community Dent, 2019, 9(6):542-552.
doi: 10.4103/jispcd.JISPCD_249_19 pmid: 32039073
[34] Cvek M. A clinical report on partial pulpotomy and capping with calcium hydroxide in permanent incisors with complicated crown fracture[J]. J Endod, 1978, 4(8):232-237.
doi: 10.1016/S0099-2399(78)80153-8
[35] Gudkina J, Mindere A, Locane G, et al. Review of the success of pulp exposure treatment of cariously and traumatically exposed pulps in immature permanent incisors and molars[J]. Stomatologija, 2012, 14(3):71-80.
[36] Harms CS, Schäfer E, Dammaschke T. Clinical eva-luation of direct pulp capping using a calcium silicate cement-treatment outcomes over an average period of 2.3 years[J]. Clin Oral Investig, 2019, 23(9):3491-3499.
doi: 10.1007/s00784-018-2767-5
[37] Asgary S, Fazlyab M, Sabbagh S, et al. Outcomes of different vital pulp therapy techniques on symptomatic permanent teeth: a case series[J]. Iran Endod J, 2014, 9(4):295-300.
[38] Bimstein E, Rotstein I. Cvek pulpotomy-revisited[J]. Dent Traumatol, 2016, 32(6):438-442.
doi: 10.1111/edt.12297 pmid: 27397639
[39] Khouja F, Abdelaziz M, Bortolotto T, et al. Intra-pul-pal and subsurface temperature rise during tooth irradiation with 808 nm diode laser: an in vitro study[J]. Eur J Paediatr Dent, 2017, 18(1):56-60.
doi: 10.23804/ejpd.2017.18.01.12 pmid: 28494605
[40] Türkün M, Türkün LS, Celik EU, et al. Bactericidal effect of Er, Cr: YSGG laser on Streptococcus mutans[J]. Dent Mater J, 2006, 25(1):81-86.
pmid: 16706301
[41] Olivi G, Genovese MD, Caprioglio C. Evidence-based dentistry on laser paediatric dentistry: review and outlook[J]. Eur J Paediatr Dent, 2009, 10(1):29-40.
pmid: 19364243
[42] Tozar KN, Erkmen Almaz M. Evaluation of the efficacy of erbium, chromium-doped yttrium, scandium, gallium, and garnet laser in partial pulpotomy in permanent immature molars: a randomized controlled trial[J]. J Endod, 2020, 46(5):575-583.
doi: 10.1016/j.joen.2020.02.003
[43] Chrepa V, Pitcher B, Henry MA, et al. Survival of the apical papilla and its resident stem cells in a case of advanced pulpal necrosis and apical periodontitis[J]. J Endod, 2017, 43(4):561-567.
doi: 10.1016/j.joen.2016.09.024
[44] Frank RM, Sargentini-Maier ML, Turlot JC, et al. Comparison of lead levels in human permanent tee-th from Strasbourg, Mexico City, and rural zones of Alsace[J]. J Dent Res, 1990, 69(1):90-93.
pmid: 2303602
[45] Linsuwanont P, Kulvitit S, Santiwong B. Reinforcement of simulated immature permanent teeth after mineral trioxide aggregate apexification[J]. J Endod, 2018, 44(1):163-167.
doi: S0099-2399(17)31032-4 pmid: 29153732
[46] Cvek M. Prognosis of luxated non-vital maxillary incisors treated with calcium hydroxide and filled with gutta-percha. A retrospective clinical study[J]. Dent Traumatol, 1992, 8(2):45-55.
doi: 10.1111/edt.1992.8.issue-2
[47] Andreasen JO, Farik B, Munksgaard EC. Long-term calcium hydroxide as a root canal dressing may increase risk of root fracture[J]. Dent Traumatol, 2002, 18(3):134-137.
pmid: 12110105
[48] Li CS, Zheng Z, Deng XH, et al. Apexification ma-nagement of mandibular second premolar with a blunderbuss apex and periapical lesion of an adult patient[J]. Case Rep Dent, 2019, 2019:7546842.
[49] Songtrakul K, Azarpajouh T, Malek M, et al. Modified apexification procedure for immature permanent teeth with a necrotic pulp/apical periodontitis: a case series[J]. J Endod, 2020, 46(1):116-123.
doi: S0099-2399(19)30748-4 pmid: 31761331
[50] Lin J, Zeng Q, Wei X, et al. Regenerative endodontics versus apexification in immature permanent tee-th with apical periodontitis: a prospective rando-mized controlled study[J]. J Endod, 2017, 43(11):1821-1827.
doi: 10.1016/j.joen.2017.06.023
[51] Alvandifar S, Madani Z, Bizhani A. Evaluation of tooth discoloration after treatment with mineral trioxide aggregate, calcium-enriched mixture, and Biodentine® in the presence and absence of blood[J]. Dent Res J (Isfahan), 2019, 16(6):377-383.
doi: 10.4103/1735-3327.270787
[52] 凌均棨, 林家成. 牙髓血运重建术治疗进展[J]. 口腔医学, 2019, 39(10):865-872.
Ling JQ, Lin JC. Research progress of regenerative endodontics[J]. Stomatology, 2019, 39(10):865-872.
[53] Kim SG, Malek M, Sigurdsson A, et al. Regenerative endodontics: a comprehensive review[J]. Int Endod J, 2018, 51(12):1367-1388.
doi: 10.1111/iej.12954 pmid: 29777616
[54] Hargreaves KM, Diogenes A, Teixeira FB. Treatment options: biological basis of regenerative endodontic procedures[J]. Pediatr Dent, 2013, 35(2):129-140.
pmid: 23635981
[55] Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract[J]. Dent Traumatol, 2001, 17(4):185-187.
pmid: 11585146
[56] 刘斌, 梁景平. 牙髓再生的临床应用与未来[J]. 中华口腔医学杂志, 2020, 55(1):50-55.
Liu B, Liang JP. Regenerative endodontics: clinical application status and future perspective[J]. Chin J Stomatol, 2020, 55(1):50-55.
[57] de Souza BDM, Dutra KL, Reyes-Carmona J, et al. Incidence of root resorption after concussion, subluxation, lateral luxation, intrusion, and extrusion: a systematic review[J]. Clin Oral Investig, 2020, 24(3):1101-1111.
doi: 10.1007/s00784-020-03199-3
[58] Santiago CN, Pinto SS, Sassone LM, et al. Revascularization technique for the treatment of external inflammatory root resorption: a report of 3 cases[J]. J Endod, 2015, 41(9):1560-1564.
doi: 10.1016/j.joen.2015.03.019
[59] Yoshpe M, Einy S, Ruparel N, et al. Regenerative endodontics: a potential solution for external root resorption (case series)[J]. J Endod, 2020, 46(2):192-199.
doi: 10.1016/j.joen.2019.10.023
[60] Lu J, Liu H, Lu ZJ, et al. Regenerative endodontic procedures for traumatized immature permanent tee-th with severe external root resorption and root perforation[J]. J Endod, 2020, 46(11):1610-1615.
doi: 10.1016/j.joen.2020.07.022
[1] 李转转,格根塔娜. 牙髓血运重建术和根尖诱导成形术疗效对比的Meta分析[J]. 国际口腔医学杂志, 2023, 50(2): 177-185.
[2] 周灿,曾倩,韦曦. 浓缩生长因子在活髓保存治疗中的应用前景[J]. 国际口腔医学杂志, 2022, 49(6): 684-689.
[3] 李转转,格根塔娜. 牙髓血运重建术根管冲洗消毒药物的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 569-577.
[4] 周易,赵玉鸣. 牙髓再生支架材料的研究进展[J]. 国际口腔医学杂志, 2022, 49(1): 19-26.
[5] 廖汶晓,马心笛,洪志薇,吴昕彧,邢云娣,刘经纬,陈蕾. 前牙复杂冠根折外科手术冠向复位治疗的早期效果[J]. 国际口腔医学杂志, 2021, 48(5): 541-548.
[6] 周懿婕,宋光泰. 年轻恒牙挫入性损伤的处理策略[J]. 国际口腔医学杂志, 2021, 48(2): 135-140.
[7] 李梅,文宁宁,赵媛. 年轻恒牙牙髓坏死后治疗方案的选择[J]. 国际口腔医学杂志, 2020, 47(4): 445-451.
[8] 马心笛,陈蕾. 完全脱位牙再植的牙髓、牙周膜愈合:从生物学基础到牙外伤指南[J]. 国际口腔医学杂志, 2020, 47(3): 336-344.
[9] 江义笛,汪成林,叶玲. 再生性牙髓治疗的并发症[J]. 国际口腔医学杂志, 2019, 46(1): 73-77.
[10] 朱远兵, 汪俊. 定制牙托膜片切牙区厚度变化的影响因素[J]. 国际口腔医学杂志, 2017, 44(5): 583-586.
[11] 雷期音, 陈柯. 年轻恒牙牙髓再生的临床应用进展[J]. 国际口腔医学杂志, 2017, 44(3): 267-272.
[12] 黄晓,汪俊. 前牙冠折断端再接粘接效果的影响因素[J]. 国际口腔医学杂志, 2015, 42(5): 568-571.
[13] 何怡1 邹静2 杨燃1. 年轻恒牙外伤固定方法的研究进展[J]. 国际口腔医学杂志, 2013, 40(1): 129-131.
[14] 刘佳佳1综述 秦满2审校. 根管内血运重建用于年轻恒牙牙髓坏死的治疗[J]. 国际口腔医学杂志, 2012, 39(3): 349-352.
[15] 姚林洁,王孜,宋光泰. 无机三氧化物聚合体用于年轻恒牙根尖封闭的短期疗效观察[J]. 国际口腔医学杂志, 2009, 36(2): 137-137~139.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .