国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (5): 574-580.doi: 10.7518/gjkq.2020085

• 综述 • 上一篇    下一篇

义齿组织调整剂的研究进展

章婷婷(),胡常红,彭燕()   

  1. 重庆市高校市级口腔生物医学工程重点实验室 重庆 401147
  • 收稿日期:2019-12-25 修回日期:2020-06-12 出版日期:2020-09-01 发布日期:2020-09-16
  • 通讯作者: 彭燕
  • 作者简介:章婷婷,硕士,Email: 2017110876@stu.cqmu.edu.cn
  • 基金资助:
    重庆医科大学附属口腔医院重点科研培育项目(PYZD201603);2016年重庆市高校创新团队建设计划资助项目(CXTDG201602006)

Research progress on denture tissue conditioner

Zhang Tingting(),Hu Changhong,Peng Yan()   

  1. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China
  • Received:2019-12-25 Revised:2020-06-12 Online:2020-09-01 Published:2020-09-16
  • Contact: Yan Peng
  • Supported by:
    Key Research Cultivating Project of Stomatological Hospital of Chongqing Medical University(PYZD201603);Program for Innovation Team Building at Institutions of Higher Education in Chongqing in 2016(CXTDG201602006)

摘要:

组织调整剂是一种临时性的软衬材料,由聚合物粉末和液体增塑剂混合形成具有流动性的黏弹性体,应用于义齿基托组织面。放入口内时具有柔软的弹性,进入临床可塑期,随着增塑剂浸出而变硬,进入临床不可变期。根据其可操作性,在临床应用于调整变形、发炎的黏膜组织,制取动态功能性印模,临时衬垫义齿,维持义齿的适合性等。本文将对组织调整剂的组成及凝胶化过程、添加抗真菌剂进行改良、物理性能、临床应用及使用方法等方面的研究进展进行综述。

关键词: 组织调整剂, 义齿性口炎, 抗真菌, 治疗义齿, 义齿空间, 动态功能印模

Abstract:

Tissue conditioners, which are short-term soft liners with viscoelasticity and fluidity, are formed from a mixture of a polymer powder and a liquid plasticizer and applied to the tissue surface of the denture base. Tissue conditioners have soft viscoelasticity when placed in the mouth, thereby entering the clinical plasticity period, and harden with the leaching of the plasticizer, thereby entering the clinical invariable period. In accordance with its operability, tissue conditioners are used clinically to adjust deformed and inflamed mucosal tissues, make dynamic functional impressions, temporarily line dentures, and maintain the suitability of dentures. This article reviews the recent advances in the composition and gelation process, improvement by adding antifungal agents, physical properties, clinical applications, and use of tissue conditioners.

Key words: tissue conditioner, denture stomatitis, antifungal, treatment denture, denture space, dynamic functional impression

中图分类号: 

  • R783.6
[1] Lytle RB. The management of abused oral tissues in complete denture construction[J]. J Prosthet Dent, 1957,7(1):27-42.
doi: 10.1016/0022-3913(57)90006-9
[2] Lytle R. Complete denture construction based on a study of the deformation of the underlying soft tissues[J]. J Prosthet Dent, 1959,9(4):539-551.
[3] 本鄉英彰. 全口义齿新境界: 义齿空间的恢复及中立区的新观念与技巧(由义齿空间的回复来判断全口义齿的形态)[M]. 本鄉英彰, 王益晖, 译. 台北: 日毅企业有限公司, 2017: 3.
Benxiang YZ . New realm of complete denture: res-toration of denture space and new concepts and skills of neutral zone (judging the shape of complete den-ture by restoration of denture space)[M]. Benxiang YZ, Wang YH, translate. Taibei: Riyi Enterprise Co., Ltd, 2017: 3.
[4] Dorocka-Bobkowska B, Medyński D, Pryliński M. Recent advances in tissue conditioners for prosthetic treatment: a review[J]. Adv Clin Exp Med, 2017,26(4):723-728.
pmid: 28691420
[5] Jones DW, Sutow EJ, Graham BS, et al. Influence of plasticizer on soft polymer gelation[J]. J Dent Res, 1986,65(5):634-642.
pmid: 3457816
[6] Murata H, Chimori H, Hamada T, et al. Viscoelasticity of dental tissue conditioners during the Sol-gel transi-tion[J]. J Dent Res, 2005,84(4):376-381.
pmid: 15790747
[7] Parker S, Braden M. Effect of composition on the gelation of tissue conditioners[J]. Biomaterials, 1996,17(18):1827-1832.
pmid: 8879523
[8] Monzavi A, Siadat H, Atai M, et al. Comparative evaluation of physical properties of four tissue con-ditioners relined to modeling plastic material[J]. J Dent (Tehran), 2013,10(6):506-515.
[9] Parker S, Braden M. The effect of particle size on the gelation of tissue conditioners[J]. Biomaterials, 2001,22(14):2039-2042.
doi: 10.1016/S0142-9612(00)00391-4
[10] Murata H, Narasaki Y, Hamada T, et al. An alcohol-free tissue conditioner: a laboratory evaluation[J]. J Dent, 2006,34(4):307-315.
pmid: 16216404
[11] Negrini TC, Koo H, Arthur RA. Candida-bacterial biofilms and host-microbe interactions in oral diseases[J]. Adv Exp Med Biol, 2019,1197:119-141.
pmid: 31732939
[12] Gulati M, Nobile CJ. Candida albicans biofilms: de- velopment, regulation, and molecular mechanisms[J]. Microbes Infect, 2016,18(5):310-321.
pmid: 26806384
[13] Dental Supplement, Contaldo M, Romano A, et al. Association between denture stomatitis, Candida species and diabetic status[J]. J Biol Regul Homeost Agents, 2019,33(3 Suppl 1):35-41.
pmid: 31538448
[14] Kim HJ, Son JS, Kwon TY. Antifungal effect of a dental tissue conditioner containing nystatin-loaded alginate microparticles[J]. J Nanosci Nanotechnol, 2018,18(2):848-852.
pmid: 29448504
[15] Bueno MG, Urban VM, Barbério GS, et al. Effect of antimicrobial agents incorporated into resilient den-ture relines on the Candida albicans biofilm[J]. Oral Dis, 2015,21(1):57-65.
pmid: 24219354
[16] Iqbal Z, Zafar MS. Role of antifungal medicaments added to tissue conditioners: a systematic review[J]. J Prosthodont Res, 2016,60(4):231-239.
doi: 10.1016/j.jpor.2016.03.006 pmid: 27085676
[17] Nam KY. In vitro antimicrobial effect of the tissue conditioner containing silver nanoparticles[J]. J Adv Prosthodont, 2011,3(1):20-24.
doi: 10.4047/jap.2011.3.1.20 pmid: 21503189
[18] Kreve S, Oliveira VC, Bachmann L, et al. Influence of AgVO3 incorporation on antimicrobial properties, hardness, roughness and adhesion of a soft denture liner[J]. Sci Rep, 2019,9(1):11889.
doi: 10.1038/s41598-019-48228-8 pmid: 31417116
[19] Mousavi SA, Ghotaslou R, Akbarzadeh A, et al. Eva-luation of antibacterial and antifungal properties of a tissue conditioner used in complete dentures after incorporation of ZnO-Ag nanoparticles[J]. J Dent Res Dent Clin Dent Prospects, 2019,13(1):11-18.
doi: 10.15171/joddd.2019.002 pmid: 31217913
[20] Uchimaru M, Sakai T, Moroi R, et al. Antimicrobial and antifungal effects of tissue conditioners contai-ning a photocatalyst[J]. Dent Mater J, 2011,30(5):691-699.
doi: 10.4012/dmj.2010-203
[21] Takakusaki K, Fueki K, Tsutsumi C, et al. Effect of incorporation of surface pre-reacted glass ionomer filler in tissue conditioner on the inhibition of Candi-da albicans adhesion[J]. Dent Mater J, 2018,37(3):453-459.
doi: 10.4012/dmj.2017-171 pmid: 29415971
[22] Sharma S, Hegde V. Comparative evaluation of anti-fungal activity of melaleuca oil and fluconazole when incorporated in tissue conditioner: an in vitro study[J]. J Prosthodont, 2014,23(5):367-373.
doi: 10.1111/jopr.12117
[23] Krishnamoorthy G, Narayana AI, Peralam PY, et al. To study the effect of cocos nucifera oil when in-corporated into tissue conditioner on its tensile strength and antifungal activity: an in vitro study[J]. J Indian Prosthodont Soc, 2019,19(3):225-232.
doi: 10.4103/jips.jips_387_18 pmid: 31462861
[24] Amornvit P, Choonharuangdej S, Srithavaj T. Le-mongrass-incorporated tissue conditioner against Candida albicans culture[J]. J Clin Diagn Res, 2014, 8(7): ZC50-ZC52.
doi: 10.7860/JCDR/2014/8378.4607 pmid: 25177638
[25] Srivatstava A, Ginjupalli K, Perampalli NU, et al. Evaluation of the properties of a tissue conditioner containing origanum oil as an antifungal additive[J]. J Prosthet Dent, 2013,110(4):313-319.
doi: 10.1016/S0022-3913(13)60381-9 pmid: 24079567
[26] Naito Y, Yumoto H, Kumar Hs K, et al. Antifungal and mechanical properties of tissue conditioner con-taining plant-derived component: an in vitro study[J]. J Prosthodont, 2018,27(7):665-669.
doi: 10.1111/jopr.12546 pmid: 28901663
[27] Kumar SM, Kumar VA, Natarajan P, et al. Antifungal efficacy and the mechanical properties of soft liners against Candida albicans after the incorporation of garlic and neem: an in vitro study[J]. J Int Soc Prev Community Dent, 2018,8(3):212-217.
doi: 10.4103/jispcd.JISPCD_343_17 pmid: 29911057
[28] Saeed A, Haider A, Zahid S, et al. In-vitro antifungal efficacy of tissue conditioner-chitosan composites as potential treatment therapy for denture stomatitis[J]. Int J Biol Macromol, 2019,125:761-766.
doi: 10.1016/j.ijbiomac.2018.12.091 pmid: 30543887
[29] Mousavi SA, Ghotaslou R, Kordi S, et al. Antibac-terial and antifungal effects of chitosan nanoparticles on tissue conditioners of complete dentures[J]. Int J Biol Macromol, 2018,118(Pt A):881-885.
doi: 10.1016/j.ijbiomac.2018.06.151 pmid: 29964105
[30] de Moraes AP, Barwaldt CK, Nunes TZ, et al. Effect of triazine derivative added to denture materials on a microcosm biofilm model[J]. J Biomed Mater Res Part B Appl Biomater, 2012,100(5):1328-1333.
doi: 10.1002/jbm.b.32699 pmid: 22639096
[31] Sampaio FN, Pinto JR, Turssi CP, et al. Effect of sealant application and thermal cycling on bond strength of tissue conditioners to acrylic resin[J]. Braz Dent J, 2013,24(3):247-252.
doi: 10.1590/0103-6440201302118 pmid: 23969914
[32] Graham BS, Jones DW, Sutow EJ. An in vivo and in vitro study of the loss of plasticizer from soft polymer-gel materials[J]. J Dent Res, 1991,70(5):870-873.
doi: 10.1177/00220345910700050101 pmid: 2022769
[33] Nimmo A, Fong BJ, Hoover CI, et al. Vacuum treat-ment of tissue conditioners[J]. J Prosthet Dent, 1985,54(6):814-817.
doi: 10.1016/0022-3913(85)90477-9 pmid: 3908663
[34] Singh K, Chand P, Singh BP, et al. Study of the effect of surface treatment on the long term effectiveness of tissue conditioner[J]. J Oral Sci, 2010,52(2):261-265.
doi: 10.2334/josnusd.52.261 pmid: 20587951
[35] Malmström HS, Mehta N, Sanchez R, et al. The effect of two different coatings on the surface integrity and softness of a tissue conditioner[J]. J Prosthet Dent, 2002,87(2):153-157.
doi: 10.1067/mpr.2002.121407 pmid: 11854670
[36] Hayakawa I, Takahashi Y, Morizawa M, et al. The effect of fluorinated copolymer coating agent on tissue conditioners[J]. Int J Prosthodont, 1997,10(1):44-48.
pmid: 9484069
[37] Gupta P, Ariga P, Deogade SC. Effect of monopoly-coating agent on the surface roughness of a tissue conditioner subjected to cleansing and disinfection: a contact profilometric in vitro study[J]. Contemp Clin Dent, 2018,9(Suppl 1):S122-S126.
pmid: 29962776
[38] Raval HJ, Mahajan N, Naveen YG, et al. A three month comparative evaluation of the effect of dif-ferent surface treatment agents on the surface integrity and softness of acrylic based soft liner: an in vivo study[J]. J Clin Diagn Res, 2017, 11(9): ZC88-ZC91.
doi: 10.7860/JCDR/2017/28604.10680 pmid: 29207842
[39] Olan-Rodriguez L, Minah GE, Driscoll CF. Candida albicans colonization of surface-sealed interim soft liners[J]. J Prosthodont, 2000,9(4):184-188.
doi: 10.1111/j.1532-849x.2000.00184.x pmid: 11320469
[40] Boscato N, Delavi JD, Muller L, et al. Influence of varnish application on a tissue conditioner: analysis of biofilm adhesion[J]. Gerodontology, 2010,27(3):207-210.
doi: 10.1111/j.1741-2358.2009.00290.x pmid: 19371389
[41] 赵铱民. 口腔修复学[M]. 7版. 北京: 人民卫生出版社, 2018: 310.
Zhao YM. Prosthodontics[M]. 7th ed. Beijing: People’s Medical Publishing House, 2018: 310.
[42] Chaturvedi S, Abdelmonem AM, Haralur S, et al. An in vivo study to compare location of neutral zone re- corded with two materials[J]. J Contemp Dent Pract, 2019,20(2):239-246.
pmid: 31058642
[43] Shylesh KB, Hallikerimath RB, Rajeev VV, et al. Evaluation of physical properties of tissue condi-tioning materials as used in functional impression—a lab study[J]. J Int Oral Health, 2013,5(3):20-27.
pmid: 24155598
[44] McCarthy JA, Moser JB. Tissue conditioners as functional impression materials[J]. J Oral Rehabil, 1978,5(4):357-364.
doi: 10.1111/j.1365-2842.1978.tb01254.x pmid: 280636
[45] Baslas V, Singh SV, Aggarwal H, et al. A technique for using short term soft liners as complete dentures final impression material[J]. J Oral Biol Craniofac Res, 2014,4(3):204-207.
pmid: 25737945
[46] Chander S, Hill M, Moore D, et al. Tissue conditioning materials as functional impression materials[J]. Eur J Prosthodont Restor Dent, 2007,15(2):67-71.
pmid: 17645067
[47] Murata H, Hamada T, Djulaeha E, et al. Rheology of tissue conditioners[J]. J Prosthet Dent, 1998,79(2):188-199.
doi: 10.1016/s0022-3913(98)70215-x pmid: 9513106
[48] 周文翘, 刘蝶, 陈陶, 等. 过渡性治疗义齿在疑难全口义齿修复前的临床应用初探[J]. 华西口腔医学杂志, 2018,36(3):277-281.
Zhou WQ, Liu D, Chen T , et al. Preliminary study on the clinical application of temporary treatment denture in difficult edentulous cases before complete denture restoration[J]. West China J Stomatol, 2018,36(3):277-281.
[49] Newsome PR, Basker RM, Bergman B, et al. The softness and initial flow of temporary soft lining materials[J]. Acta Odontol Scand, 1988,46(1):9-17.
doi: 10.3109/00016358809004741 pmid: 3164166
[1] 周羽洁, 任彪, 程磊, 周学东. 白假丝酵母菌在义齿性口炎中的相关研究[J]. 国际口腔医学杂志, 2017, 44(4): 477-483.
[2] 李莉娜, Young Kim, 舒毅, Renate Lux, 田敏, Prasad Adusumilli, Zvi Loewy, 郭宏, Yu Sha. 不同清洗方式对义齿白色假丝酵母菌生物膜清除效果的影响[J]. 国际口腔医学杂志, 2010, 37(02): 157-157~160.
[3] 吕川,张帅综述 高宁审校. 义齿性口炎的病因研究[J]. 国际口腔医学杂志, 2008, 35(6): 697-697~700.
[4] 王萍. 义齿性口炎的研究[J]. 国际口腔医学杂志, 1999, 26(05): -.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张京剧. 青年期至中年期颅面复合体变化的头影测量研究[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 刘玲. 镍铬合金中铍对可铸造性和陶瓷金属结合力的影响[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 王昆润. 在种植体上制作固定义齿以后下颌骨密度的动态变化[J]. 国际口腔医学杂志, 1999, 26(06): .
[4] 王昆润. 重型颌面部炎症死亡和康复病例的实验室检查指标比较[J]. 国际口腔医学杂志, 1999, 26(06): .
[5] 逄键梁. 两例外胚层发育不良儿童骨内植入种植体后牙槽骨生长情况[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 温秀杰. 氟化物对牙本质脱矿抑制作用的体外实验研究[J]. 国际口腔医学杂志, 1999, 26(05): .
[7] 杨春惠. 耳颞神经在颞颌关节周围的分布[J]. 国际口腔医学杂志, 1999, 26(04): .
[8] 王昆润. 牙周炎加重期应选用何种抗生素[J]. 国际口腔医学杂志, 1999, 26(04): .
[9] 杨儒壮 孙宏晨 欧阳喈. 纳米级高分子支架材料在组织工程中的研究进展[J]. 国际口腔医学杂志, 2004, 31(02): 126 -128 .
[10] 严超然,李龙江. 肿瘤靶向药物载体系统的研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .