国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (4): 431-436.doi: 10.7518/gjkq.2019054

• 综述 • 上一篇    下一篇

表没食子儿茶素没食子酸酯在干细胞增殖及成骨分化作用中的研究现状

梅宏翔1,张懿丹1,张城浩2,刘恩言1,陈昊1,赵志河2,廖文2()   

  1. 1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院 成都 610041
    2. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院正畸科 成都 610041
  • 收稿日期:2018-11-10 修回日期:2019-04-02 出版日期:2019-07-10 发布日期:2019-07-12
  • 作者简介:梅宏翔,学士,Email: 978604542@qq.com
  • 基金资助:
    国家自然科学基金(31600752);四川大学大学生创新创业训练计划(C2018103847);四川大学-泸州市人民政府战略合作项目(2018CDLZ-14)

Effect of epigallocatechin-3-gallate on stem cell proliferation and osteogenic differentiation

Mei Hongxiang1,Zhang Yidan1,Zhang Chenghao2,Liu Enyan1,Chen Hao1,Zhao Zhihe2,Liao Wen2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China;
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
  • Received:2018-11-10 Revised:2019-04-02 Online:2019-07-10 Published:2019-07-12
  • Supported by:
    This study was supported by National Natural Science Foundation of China(31600752);Undergraduate Student Innovation and Entrepreneurship Training Program of Sichuan University(C2018103847);Sichuan University-Luzhou Municipal Government Strategic Cooperation Project(2018CDLZ-14)

摘要:

表没食子儿茶素没食子酸酯(EGCG)是茶叶中多酚类化合物的主要组成部分。近年来许多研究证明,作为一种抗氧化剂,EGCG能够参与调节多种生命过程,在抗炎以及抑制肿瘤生长等方面都具有重要作用。流行病学调查和动物实验都证实,EGCG能够抑制牙周炎及其引起的骨质流失,是牙周治疗的潜在辅助治疗药物。由于兼具抗炎和促成骨功能,EGCG在骨质缺损修复的组织工程材料改性中也具有极大的潜力。本文就EGCG对干细胞的增殖及成骨分化的作用机制进行综述,并总结其作为组织工程材料的优劣,为EGCG在牙周炎辅助治疗药物和骨组织工程材料等方面的研究与应用提供理论依据。

关键词: 表没食子儿茶素没食子酸酯, 增殖, 成骨分化, 组织工程

Abstract:

Tea polyphenols are a general term for polyphenols in tea, and epigallocatechin-3-gallate (EGCG) is a major component. As an antioxidant, EGCG can participate in the regulation of various life processes, including anti-inflammatory and anti-tumour activities. Epidemiological investigations and animal experiments have confirmed that EGCG can inhibit periodontitis and subsequent bone loss. Therefore, it might be a potential adjuvant treatment for periodontal treatment. Due to its anti-inflammatory and osteogenic functions, EGCG also has great potential in the modification of tissue engineering materials for bone defect repair. This article reviews the mechanism by which EGCG participates in stem cell proliferation and osteogenic differentiation, and summarises its advantages as a tissue engineering material. This paper provides a theoretical basis for the use of EGCG as periodontitis adjuvant therapy and bone tissue engineering material.

Key words: epigallocatechin-3-gallate, proliferation, osteogenesis, tissue engineering

中图分类号: 

  • Q254

图 1

EGCG的结构"

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