国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (1): 30-36.doi: 10.7518/gjkq.2019.01.006

• 综述 • 上一篇    下一篇

受体活性修饰蛋白1促进成骨作用的研究进展

张勤,宫苹()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院种植科 成都 610041
  • 收稿日期:2018-05-24 修回日期:2018-07-19 出版日期:2019-01-01 发布日期:2019-01-11
  • 通讯作者: 宫苹
  • 作者简介:张勤,硕士,Email：zhangq0312@hotmail.com
  • 基金资助:
    国家自然科学基金(81571008);国家自然科学基金(81701007);四川省科技计划(2018RZ0087);中央高校基本科研业务费专项资金(2017SCU-12056);中央高校基本科研业务费专项资金(2018SCUH0006);中国博士后科学基金资助项目(2018M-631091);四川大学华西口腔医院青年科学研究基金项目(2016-11)

Advancements in receptor activity-modifying protein-1 for osteogenesis

Qin Zhang,Ping Gong()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantation, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-05-24 Revised:2018-07-19 Online:2019-01-01 Published:2019-01-11
  • Contact: Ping Gong
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81571008);This study was supported by National Natural Science Foundation of China(81701007);Sichuan Science and Technology Program(2018RZ0087);the Fundamental Research Funds for the Central Universities(2017SCU-12056);the Fundamental Research Funds for the Central Universities(2018SCUH0006);Project Funded by China Postdoctoral Science Foundation(2018M-631091);the Youth Science Foundation of West China Hospital of Stomatology of Sichuan University(2016-11)

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摘要：

生理状态下,骨吸收与骨形成过程的动态平衡对维持骨组织功能至关重要。而在骨损伤状态下,如何通过促进骨形成,抑制骨吸收从而促进骨愈合过程一直是该领域研究的热点。近年来,受体活性修饰蛋白-1（RAMP1）在骨代谢过程中的调节作用已受到越来越多的关注。RAMP1广泛存在于骨组织中,它可以与不同的G蛋白偶联受体（GPCR）结合,修饰受体行为,调节相应的配体作用。此外,它还能进一步参与到受体介导的信号转导中,影响成骨相关细胞内蛋白的相互作用,从而影响成骨相关细胞增殖、迁移、分化等生物学特性。本文就近年来RAMP1促进成骨作用的研究作一综述。

关键词: 受体活性修饰蛋白1, 降钙素基因相关肽, 成骨作用, G蛋白偶联受体, 降钙素受体样受体

Abstract:

Under physiological conditions, the dynamic balance between bone resorption and bone formation is necessary to maintain bone tissue function. However, whether we can further accelerate or improve osteogenesis process during bone wound healing has been widely explored. Receptor activity-modifying protein-1 (RAMP1) has been extensively investigated because of its extensive biological activities, especially its effects on bone fracture repair. RAMP1 is commonly found in bone tissues and can interact with G-protein coupled receptors to modify their activities. RAMP1 also has a broader role in regulating receptor trafficking and signaling, affecting the biological characteristics of osteoblasts, such as proliferation, migration, and differentiation. Thus, this review summarizes recent studies about the effects of RAMP1 on osteogenesis.

Key words: receptor activity-modifying protein-1, calcitonin gene-related peptide, osteogenesis, G-protein coupled receptor, calcitonin receptor-like receptor

中图分类号: 

  • Q51

表1

常见的RAMPs家族参与构成的受体"

受体名称 受体主要分子组成
CGRP受体 CLR+RAMP1
AM1受体 CLR+RAMP2/3
AM2受体 CLR+RAMP1/2/3
AMY受体 CTR+RAMP1/2/3
VPAC受体 VPAC受体+RAMP1/2/3
PTH1受体 PTH1受体+RAMP2
PTH2受体 PTH2受体+RAMP3
CaSR CaSR+RAMP1/2/3

图1

RAMP1参与CGRP促进成骨作用的机制 N：氮末端;C：碳末端;RCP：受体组分蛋白（receptor com-ponent protein）;AC：腺苷酸环化酶（adenylate cyclase）;ADP：二磷酸腺苷（adenosine diphosphate）; PKA：蛋白激酶A（protein kinase A）;CREB1：环磷酸腺苷应答元件结合蛋白1（cyclic adenosine monophosphate response element binding protein 1）;SP7/Osterix：锌指结构转录因子。"

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