国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (3): 276-279.doi: 10.7518/gjkq.2018.03.006

• 干细胞专栏 • 上一篇    下一篇

牙源性干细胞的免疫调节作用

张湘宜, 刘亚丽   

  1. 昆明医科大学附属口腔医院正畸科 昆明 650032
  • 收稿日期:2017-04-08 修回日期:2017-10-12 发布日期:2018-05-08
  • 通讯作者: 刘亚丽,副教授,博士,Email：liuyali1006@hotmail.com
  • 作者简介:张湘宜,硕士,Email：1697800821@qq.com
  • 基金资助:
    国家自然科学基金（31301067）;教育部博士点研究基金（20135317120005）;云南省教育厅科学研究基金（2013Z106）

Immune regulation of dental stem cells

Zhang Xiangyi, Liu Yali   

  1. Dept. of Orthodontics, Stomatological Hospital of Kunming Medical University, Kunming 650032, China
  • Received:2017-04-08 Revised:2017-10-12 Published:2018-05-08
  • Supported by:
    This study was supported by National Natural Science Foundation of China (31301067), Research Fund of The Ministry of Education’s Doctoral Programs (20135317120005) and Yunnan Provincial Education Department Scientific Research Fund (2013Z106).

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摘要： 牙源性干细胞是一类从牙体或牙周组织中分离得到的干细胞,具有独特的免疫调节作用,可通过直接接触或分泌细胞因子发挥免疫抑制作用,在T细胞、B细胞等淋巴细胞的增殖、分化、凋亡等过程中扮演着重要角色。此外,牙源性干细胞对多种慢性炎症性疾病、自身免疫性疾病的治疗有一定临床指导意义。本文对几种常见的牙源性干细胞的免疫调节作用进行简要综述。

关键词: 牙源性干细胞, 免疫调节, 干细胞治疗

Abstract: Dental stem cell (DSC) is a type of stem cells that possess unique immunomodulation properties and can be effectively obtained from isolated dental or periodontal tissue. They exert immunosuppressive effects through direct contact or secretion of cytokines and play a key role in the proliferation, differentiation, and apoptosis of T cells, B cells, and other lymphocytes. The treatment of a variety of chronic inflammatory and autoimmune diseases has a certain clinical significance. In this review, we summarize current studies on the immunomodulatory properties of several common DSCs.

Key words: dental stem cell, immunomodulation, stem cell therapy

中图分类号: 

  • R392
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