国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (4): 488-492.doi: 10.7518/gjkq.2017.04.023

• 综述 • 上一篇    下一篇

降钙素基因相关肽在骨组织再生中的作用及机制

伍彩娟, 杨岚, 郭吕华   

  1. 广州医科大学口腔医学院•附属口腔医院修复科 广州 510140
  • 收稿日期:2016-08-20 修回日期:2017-04-14 出版日期:2017-07-01 发布日期:2017-07-01
  • 通讯作者: 郭吕华,主任医师,博士,Email：562210919@qq.com
  • 作者简介:伍彩娟,硕士,Email：451931086@qq.com
  • 基金资助:
    广东省科技计划项目（2013B021800278）; 广东省广州市荔湾区科技计划项目（20141216055）

Role and mechanism of the calcitonin gene related peptide in bone tissue regeneration

Wu Caijuan, Yang Lan, Guo Lühua   

  1. Stomatological School of Guangzhou Medical University, Dept. of Prosthodontics, Affiliated Hospital of Stomatology, Guangzhou 510140, China
  • Received:2016-08-20 Revised:2017-04-14 Online:2017-07-01 Published:2017-07-01
  • Supported by:
    This study was supported by Science and Technology Planning Project of Guangdong Province(2013B021800278) and Science and Technology Planning Project of Guangzhou Liwan District of Guangdong Province(20141216055).

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摘要： 骨量不足是目前口腔种植修复中经常面临的问题,常用的骨组织再生办法有很多,如自体骨移植、生物骨粉及富血小板纤维膜的利用等,但临床效果都不是很显著。骨是一种由破骨和成骨细胞介导的处于动态代谢更新状态的组织,骨代谢受各种全身因素的影响,降钙素基因相关肽（CGRP）是一种在人体广泛分布的神经肽,多项研究表明其在骨代谢中具有重要作用,特别是在成骨方面。其具体成骨作用及机制尚未完全清楚,一直在探讨之中,本文对此作一综述。

关键词: 降钙素基因相关肽, 骨再生, 成骨分化

Abstract: Insufficient bone mass is a common problem in oral implant prostheses. The widely used bone regeneration methods in clinical applications include autologous bone grafting and the use of biological bone powder and platelet-rich fiber membrane. Despite the variations in all the methods, the clinical effects are unremarkable. Bones involve a dynamic organization mediated by osteoclast and osteoblast metabolism, which is influenced by various systemic factors. Calcitonin gene related peptides(CGRP) are extensively distributed neuropeptides in the body. Many studies have shown that CGRP plays an important role in bone metabolism, especially in osteogenesis. However, the specific mechanism of CGRP in osteogenesis is unclear and requires further investigation and discussion. Therefore, we conducted this review to study the role and mechanism of CGRP.

Key words: calcitonin gene related peptide, bone regeneration, osteogenic differentiation

中图分类号: 

  • R68
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