国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (4): 477-483.doi: 10.7518/gjkq.2017.04.021

• 综述 • 上一篇    下一篇

白假丝酵母菌在义齿性口炎中的相关研究

周羽洁, 任彪, 程磊, 周学东   

  1. 口腔疾病研究国家重点实验室,国家口腔疾病临床研究中心,四川大学华西口腔医院牙体牙髓病科 成都 610041
  • 收稿日期:2016-12-01 修回日期:2017-02-22 出版日期:2017-07-01 发布日期:2017-07-01
  • 通讯作者: 周学东,教授,博士,Email:zhouxd@scu.edu.cn
  • 作者简介:周羽洁,硕士,Email:29852902@qq.com
  • 基金资助:
    国家自然科学基金(81430011)

Research on Candida albicans in the denture stomatitis

Zhou Yujie, Ren Biao, Cheng Lei, Zhou Xuedong   

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-12-01 Revised:2017-02-22 Online:2017-07-01 Published:2017-07-01
  • Supported by:
    This study was supported by the National Natural Science Foundation of China(81430011).

摘要: 义齿性口炎是一种发生在可摘义齿佩戴者口腔的常见病,其主要的特征为与义齿接触的口腔黏膜出现炎症与红斑或组织水肿样病损,发病机制仍不明确。研究表明,白假丝酵母菌与义齿性口炎的发生有着密切的关系。白假丝酵母菌主要通过其分泌的侵袭酶与黏附素及菌丝相的形成作为毒力因子,对宿主细胞进行感染。这一系列的毒力作用大多由某一种或几种分子通路来实现调控。本文就白假丝酵母菌在义齿性口炎中相关毒力因子的产生与作用,其分子通路及宿主细胞的反应等几个方面进行综述。

关键词: 白假丝酵母菌, 义齿性口炎, 毒力因子

Abstract: Denture stomatitis is a common disorder affecting denture wearers. The typical symptom of denture stomatitis is characterized as inflammation and erythema of the oral mucosal areas covered by the denture. However, the etiology of denture stomatitis is not completely understood. A large number of surveys have shown a strong link between Candida albicans and denture stomatitis. Basically, the C. albicans pathogenicity included different factors: adhesins, secreted enzymes, and the diversity of morphological. The virulence factors involved in the pathogenic procedures are usually mediated by one or more signal pathways of correlated genes. The aim of this paper is to review current understanding on the roles of C. albicans and its virulence factors during the denture stomatitis development, as well as the reactions of host cells when infected by C. albicans.

Key words: Candida albicans, denture stomatitis, virulence factor

中图分类号: 

  • R781.5
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