国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (3): 314-317.doi: 10.7518/gjkq.2016.03.014
王璐,李霞
Wang Lu, Li Xia
摘要: 舍格伦综合征(SS)属于腺体功能受损性自身免疫性疾病,口干症是其首要症状,发病机制不明,尚无有效的治疗方法。水通道蛋白、瞬时受体电位香草酸和舒血管肠肽与SS口干症发病密切相关,本文就三者与SS间的关系等研究进展作一综述。
中图分类号:
[1] 张洪义, 胡秀芹, 金仲品. 原发性干燥综合症临床首发症状及实验室检查100例分析[J]. 中国实用医药, 2010, 5(23):10-11. Zhang HY, Hu XQ, Jin ZP. Clinical initialdose happen symptom and laboratory examination of 100 cases analyse of PSS[J]. Chin Pract Med, 2010, 5(23):10-11. [2] Delporte C. Aquaporins in salivary glands and pancreas Delporte C. Aquaporins in salivary glands and pancreas[J]. Biochim Biophys Acta, 2014, 1840(5):1524-1532. [3] 罗慧臣, 李抨, 肖卫国. M3R与AQP5在干燥综合征患者唇腺中的表达与意义[J]. 中国免疫学杂志, 2011, 27(1):79-81, 87. Luo HC, Li P, Xiao WG. Expression of muscarinic receptor 3 and aquaporin 5 in patients with Sj?gren’s syndrome in the labial glands[J]. Chin J Immunol, 2011, 27(1):79-81, 87. [4] Ding C, Cong X, Zhang Y, et al. Hypersensitive mAChRs are involved in the epiphora of transplanted glands[J]. J Dent Res, 2014, 93(3):306-312. [5] 刘燕, 钱先. AQP5在干燥综合征发病机制中作用研究进展[J]. 辽宁中医药大学学报, 2014, 16(1):85-87. Liu Y, Qian X. Research progress of AQP5 in pathogenesis of Sj?gren’s syndrome[J]. J Liaoning Univ Tradit Chin Med, 2014, 16(1):85-87. [6] Lee BH, Gauna AE, Perez G, et al. Autoantibodies against muscarinic type 3 receptor in Sj?gren’s syndrome inhibit aquaporin 5 trafficking[J]. PLoS One, 2013, 8(1):e53113. [7] Wang D, Yuan Z, Inoue N, et al. Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats[J]. Biochim Biophys Acta, 2011, 1810(5):543-554. [8] 王頔, 秦臻, 周党侠, 等. M3受体激动剂诱导大鼠腮腺细胞内AQP5和脂质筏的核转移[J]. 基础医学与临床, 2015, 35(2):237-239. Wang D, Qin Z, Zhou DX, et al. M3 receptor agonist induced rat AQP5 and parotid gland cell nuclear transfer of lipid rafts[J]. Bas Clin Med, 2015, 35(2):237-239. [9] Nakamura M, Saga T, Watanabe K, et al. An immunohistochemistry-based study on aquaporin(AQP)-1, 3, 4, 5 and 8 in the parotid glands, submandibular glands and sublingual glands of Sj?gren’s syndrome mouse models chronically administered cevimeline[J]. Kurume Med J, 2013, 60(1):7-19. [10] Gresz V, Horvath A, Gera I, et al. Immunolocalization of AQP5 in resting and stimulated normal labial glands and in Sj?gren’s syndrome[J]. Oral Dis, 2015, 21(1):e114-e120. [11] 王松灵, 颜兴. 基因转导及组织工程重建涎腺功能[J]. 口腔颌面外科杂志, 2008, 18(3):153-157. Wang SL, Yan X. Reconstruction of salivary gland function with gene transfer or tissue engineering[J]. J Oral Maxillofac Surg, 2008, 18(3):153-157. [12] 李魁君, 李春刚, 刘兴君. 辣椒素受体(TRPV1)的生物学作用及其作为药物靶点的研究进展[J]. 沈阳药科大学学报, 2011, 28(11):917-927. Liu KJ, Li CG, Liu XJ. Progress on the capsaicin receptor-TRPV1: biological actions and as a therapeutic target for novel drugs[J]. J Shenyang Pharmaceut Univ, 2011, 28(11):917-927. [13] Zhang Y, Cong X, Shi L, et al. Activation of transient receptor potential vanilloid subtype 1 increases secretion of the hypofunctional, transplanted submandibular gland[J]. Am J Physiol Gastrointest Liver Physiol, 2010, 299(1):G54-G62. [14] Sobhan U, Sato M, Shinomiya T, et al. Immunolocalization and distribution of functional temperaturesensitive TRP channels in salivary glands[J]. Cell Tissue Res, 2013, 354(2):507-519. [15] 丛馨, 张艳, 俞光岩, 等. 激活辣椒素受体是调控下颌下腺分泌的新途径[J]. 北京大学学报: 医学版, 2015, 47(1):8-12. Cong X, Zhang Y, Yu GY, et al. Activation of transient receptor potential vanilloid subtype 1 serves as a novel path-way to modulate secretion in submandibular gland[J]. J Pek Univ: Hea Sci, 2015, 47(1):8-12. [16] Ding QW, Zhang Y, Wang Y, et al. Functional vanilloid receptor-1 in human submandibular glands [J]. J Dent Res, 2010, 89(7):711-716. [17] Hasegawa T, Azlina A, Javkhlan P, et al. Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling in salivary gland cells[J]. Am J Physiol, Cell Physiol, 2011, 301(3):C667-C678. [18] Choi S, Shin YH, Namkoong E, et al. TRPV1 in salivary gland epithelial cells is not involved in salivary secretion via transcellular pathway[J]. Korean J Physiol Pharmacol, 2014, 18(6):525-530. [19] Cong X, Zhang Y, Yang NY, et al. Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland[J]. J Cell Sci, 2013, 126(Pt 5):1109-1121. [20] Cong X, Zhang Y, Shi L, et al. Activation of transient receptor potential vanilloid subtype 1 increases expression and permeability of tight junction in normal and hyposecretory submandibular gland[J]. Lab Invest, 2012, 92(5):753-768. [21] 王洋, 张雷, 俞光岩. 辣椒素对移植颌下腺“休眠期”腺体分泌功能的影响[J]. 中华口腔医学杂志, 2007, 42(3):161-164. Wang Y, Zhang L, Yu GY. The effect of capsaicin on the secretion of the transferred submandibular gland in “latent period”[J]. Chin J Stomatol, 2007, 42(3):161-164. [22] Hauk V, Calafat M, Larocca L, et al. Vasoactive intestinal peptide/vasoactive intestinal peptide receptor relative expression in salivary glands as one endogenous modulator of acinar cell apoptosis in a murine model of Sj?gren’s syndrome[J]. Clin Exp Immunol, 2011, 166(3):309-316. [23] Jimeno R, Gomariz RP, Gutiérrez-Ca?as I, et al. New insights into the role of VIP on the ratio of Tcellsubsets during the development of autoim-mune diabetes[J]. Immunol Cell Biol, 2010, 88(7):734-745. [24] 林传权, 陈玉龙, 李茹柳, 等. 利血平对大鼠唾液蛋白分泌的影响[J]. 世界华人消化杂志, 2009, 17(17):1702-1706. Lin CQ, Chen YL, Li RL, et al. Effect of reserpine on the secretion of salivary protein in rats[J]. Wor Chin J Digestol, 2009, 17(17):1702-1706. [25] Parvin MN, Kurabuchi S, Murdiastuti K, et al. Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide in the Brunner’s gland of the rat duodenum[J]. Am J Physiol Gastrointest Liver Physiol, 2005, 288(6):G1283-G1291. (本文采编 王晴) |
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