国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (3): 314-317.doi: 10.7518/gjkq.2016.03.014

• 综述 • 上一篇    下一篇

舍格伦综合征口干症的研究进展

王璐,李霞   

  1. 山西医科大学附属口腔医院牙体牙髓病科 太原 030001
  • 收稿日期:2015-05-06 修回日期:2015-11-30 出版日期:2016-05-01 发布日期:2016-05-01
  • 通讯作者: 李霞,副教授,博士,Email:lixia6881@163.com
  • 作者简介:王璐,硕士,Email:783385893@qq.com
  • 基金资助:
    山西省科技攻关项目(20150313010-3)

Research progress on xerostomia of Sjögren syndrome

Wang Lu, Li Xia   

  1. Dept. of Conservative Dentistry and Endodontics, The Affiliated Stomatological Hospital of Shanxi Medical University, Taiyuan 030001, China) This study was supported by the Shanxi Province Science and Technology Research Program(20150313010-3).
  • Received:2015-05-06 Revised:2015-11-30 Online:2016-05-01 Published:2016-05-01

摘要: 舍格伦综合征(SS)属于腺体功能受损性自身免疫性疾病,口干症是其首要症状,发病机制不明,尚无有效的治疗方法。水通道蛋白、瞬时受体电位香草酸和舒血管肠肽与SS口干症发病密切相关,本文就三者与SS间的关系等研究进展作一综述。

关键词: 舍格伦综合征, 口干症, 水通道蛋白, 瞬时受体电位香草酸, 舒血管肠肽, 舍格伦综合征, 口干症, 水通道蛋白, 瞬时受体电位香草酸, 舒血管肠肽

Abstract: Sj?gren syndrome(SS) is a chronic autoimmune disease that occurs because of the impairment of the exocrine gland function. Xerostomia is the first sign of SS, and this symptom indicates the beginning of lesions. As the pathogenesis remains unclear, no complete treatment exists. Recently, the functions of aquaporins, capsaicin receptor, and vasoactive intestinal peptide in the pathogenesis of SS xerostomia have gradually received increasing attention. Therefore, this paper reviews the functions and treatment of these factors in the pathogenesis of SS xerostomia.

Key words: Sj?gren syndrome, xerostomia, aquaporin, transient receptor potential vanillic, vasoactive intestinal peptide, Sj?gren syndrome, xerostomia, aquaporin, transient receptor potential vanillic, vasoactive intestinal peptide

中图分类号: 

  • R 781.7
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