国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (2): 212-215.doi: 10.7518/gjkq.2016.02.021
刘双,李纾
Liu Shuang, Li Shu
摘要: 模式识别受体(PRR)是宿主抵抗病原微生物的感应器,可识别一种或多种病原体相关分子模式(PAMP),可及时向下游通路转导信号,引发先天性免疫反应。PAMP包括脂多糖(LPS)、脂磷壁酸、肽聚糖和甘露糖等。不同的PAMP可被不同的Toll样受体(TLR)识别或组合识别,然后通过一系列蛋白质级联反应激活细胞因子,从而有效地活化天然免疫系统。PAMP作用于TLR后,可促进炎性细胞因子的合成与释放;诱导一氧化氮依赖性杀菌活性和呼吸爆发;介导由细菌脂蛋白引起的人单核细胞系和表达TLR2的上皮细胞系程序性细胞死 亡;LPS通过作用于TLR4促进树突细胞成熟,诱导TLR2的合成与表达,进而分泌白细胞介素-6等细胞因子。对TLR的研究将有助于认识慢性牙周病并为其治疗提供新的方法,故本文就牙龈上皮表面的PRR和牙周致病菌表面的PAMP及其在牙周病中的防御作用等研究进展作一综述。
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