口腔鳞状细胞癌治疗特异性靶点整联蛋白-αvsub>β6sub>的研究进展

doi:10.7518/gjkq.2013.01.019

国际口腔医学杂志 ›› 2013, Vol. 40 ›› Issue (1): 72-75.doi: 10.7518/gjkq.2013.01.019

口腔鳞状细胞癌治疗特异性靶点整联蛋白-α_{vsub>β_{6sub>的研究进展}}

桑磊1，2 李宏卫2，3

1. 苏州卫生职业技术学院附属口腔医院口腔颌面外科苏州 215002 ；2. 南京医科大学口腔医学研究所；3. 南京医科大学附属口腔医院口腔颌面外科南京 210029

收稿日期:2012-04-16 修回日期:2012-10-19 出版日期:2013-01-01 发布日期:2013-01-01
通讯作者: 李宏卫， Tel： 18651801137
作者简介:桑磊（1984—），男，山东人，住院医师，硕士

Overexpression of the αvβ6 integrin in oralsquamous cell carcinoma is a specific targettor for treatment

Sang Lei 1，2 , Li Hongwei 2，3.

1. Dept. of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Suzhou Health College, Suzhou 215002, China; 2. Research Institute of Stomatology, Nanjing Medical University, Nanjing 210029, China; 3. Dept. of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing 210029, China

Received:2012-04-16 Revised:2012-10-19 Online:2013-01-01 Published:2013-01-01

摘要/Abstract

摘要：

整联蛋白（INT）-α_vβ₆是一类特殊的INT-亚型，在上皮源性恶性肿瘤组织和创伤愈合组织中高表达，在健康组织和良性肿瘤组织中不表达。INT-α_vβ₆通过促进肿瘤细胞的迁移、参与细胞外基质降解、激活转化生长因子-β₁和抑制肿瘤程序性细胞死亡等途径促进肿瘤的侵袭和转移。本文就INT-α_vβ₆、INT-α_vβ₆的信号传导、INT-α_vβ₆与口腔鳞状细胞癌和INT-α_vβ₆与肿瘤预后等研究进展作一综述。

关键词: 整联蛋白, 口腔鳞状细胞癌, 侵袭转移, 上皮—间质转化, 程序性细胞死亡

Abstract:

Integrin-α_vβ₆ is a special integrin subtype, which highly express in cancer and healing wound, but did not express in normal tissue and benign tumor. By promoting tumor cell migration and extracellular matrix degradation, activating cytokine transforming growth factor-β₁ and inhibiting tumor cell programmed cell death lead to tumor invasion and metastasis. Further study of integrin-α_vβ₆ expression and function in oral cancer will help to understand the molecular mechanisms of invasion and metastasis, provide oral squamous cell carcinoma treatment with new ideas and methods.

Key words: integrin, oral squamous cell carcinoma, invasion and metastasis, epithelial—mesenchymaltransformation, programmed cell death

桑磊1，2 李宏卫2，3. 口腔鳞状细胞癌治疗特异性靶点整联蛋白-α_{vsub>β_{6sub>的研究进展[J]. 国际口腔医学杂志, 2013, 40(1): 72-75.}}

Sang Lei 1，2,Li Hongwei 2，3.. Overexpression of the αvβ6 integrin in oralsquamous cell carcinoma is a specific targettor for treatment[J]. Inter J Stomatol, 2013, 40(1): 72-75.

参考文献

1．Sheppard D，Rozzo C，Starr L，et al.Complete amino acid sequence of a Novel integrin beta subunit（beta6） identified in epithelial cells using the polymerase chain reaction[J].J Biol Chem，1990，265（20）：11502-11507.
2．Ahmed N，Niu J，Dorahy DJ,et al.Direct integrin alphavbeta6-ERK binding:inplications for tumor growth[J].Oncogene 2002.21(9):1370-1380.
3．杨广运，徐克森，张朝阳，等。整合素αvβ6-ERK2直接通路MMP-9分泌与结肠癌转移关系的实验研究[J].中华普通外科杂志，2007，22（6）：443-435.
4．Li X ,Yang Y,Hu Y,et al Alphavbeta6-Fyn signaling promotes oral cancer progression[J].J Biol Chem,2003,278(43):41646-41653.
5.Munger JS，Huang X,Kawakatsu H，et al.The integrin alphavbeta6 binds and activates latent TGF beta1:a mechanism for regulating pulmonary inflammation and fibrosis[J].Cell,1999,96(3)319-328.
6．Huang X，Wu j，Spong S，et al.The integrin alphavbeta6 is in critical for keratinocyte migration on both its known ligand,fibronectin ,and on vitronectin[J].j cell Sci,1998,111(Pt15):2189-2195.
7.Niu J,gu X,Ahmed N,Andrews S,Tutron J,Bates R,Argez M.The alphavbeta6integrin regulates its own expressin with cell crowding implications for tumor progression[J].int J Cancer,2001 A,92(1):40-48.
8．Impola U，Uitto V J，Hietanen J.et a1．Differential expression of matrilysin-7(MMP-7)．92 kD gelatinase(MMP-9)，and metalloelastase(MMp-12)in oral verrucous and squamous eell cancer[J]．J Pathol。2004，202(1)：14—22．
9．Ramos D M。But M，Regezi J，et a1．Expression of integrin beta 6 enhances invasive behavior in oral squamous cell carcinoma[J]．Matrix Biol，2002，2l(3)：297-307．
10．Morgan M R，Thomas G J，Russell A，et a1．The integrin cyto-plasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase(MMP)-2 or MMP-9[J]．J Biol Chem，2004，279(25)：26533—26539．
11．Bates RC: Colorectal cancer progression: integrin avβ6 and the epithelial–mesenchymal transition (EMT). Cell Cycle 4: 1350-1352, 2005.
12.Mishra PJ, Humeniuk R, Medina DJ, Alexe G, Mesirov JP,Ganesan S, Glod JW and Banerjee D: Carcinoma-associatedfibroblast-like differentiation of human mesenchymal stem cells.Cancer Res 68: 4331-4339, 2008.
13．DANIEL M. RAMOS, DONGMIN DANG and STEPHEN SADLER。The Role of the Integrin αvβ6 in Regulating the Epithelial to Mesenchymal Transition in Oral Cancer。ANTICANCER RESEARCH 29: 125-130 (2009).
14． Ramsay AG, Keppler MD, Jazayeri M, Thomas GJ, Parsons M, Violette S, et al. HS1-associatedprotein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6. Cancer Res 2007;67:5275–84. [PubMed: 17545607]
15．Janes S M，Watt F M．Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis[J]．J Cell Biol，2004，166(3)：419-431．
16．Zhao-Yang Z，Ke-Sen X．Qing-Si H，et a1．Signaling and regulatory mechanisms of integrin αvβ6 on the apoptosis of colon cancer cells[J]．Cancer Lett，2008。266(2)：209-215．
17．Zhang ZY,Xu Ks,Wang JS,et al.Integrin αvβ6 Acts as a prognostic indicator in Gastric Carcinoma{J}.Clin Oncol 2008,20(1):61-65.
18． Elayadi AN,Samli KN，Prudkin L，et al。A peptide selected by biopanning identifies the integrin alphavbeta6 as a progonstic biomarker for nonsmall cell lung cancer[J].Cancer Res ,2007,67(12):5889-5895.
19．Hazelbag S.Kenter GG.Gorter A,et al.Overexpression of the alphavbeta6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survial[J].J Pathol,2007,212(3)316-324.
20．Sven H. Hausner, Craig K. Abbey，Richard J. Bold，et al。Targeted In vivo Imaging of Integrin αvβ6 with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model。[Cancer Res 2009;69(14):5843–50
21．Mignogna MD, Fedele S, Lo Russo L. The World CancerReport and the burden of oral cancer. Eur J Cancer Prev2004;13:139–142.
22．Huang X，Wu J，Spong S，et al。The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand，fibronectin，and on vitroncetin[J].J Cell Sci，1998,111（pt15）：2189-2195

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口腔鳞状细胞癌治疗特异性靶点整联蛋白-α_{vsub>β_{6sub>的研究进展}}

Overexpression of the αvβ6 integrin in oralsquamous cell carcinoma is a specific targettor for treatment

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